Synthesis of silymarin−selenium nanoparticle conjugate and examination of its biological activity in vitro
Silymarin (Sil) was conjugated to selenium nanoparticles (SeNPs) to increase Sil bioavailability. The conjugates were monodisperse; the average diameter of the native SeNPs was ~ 20-50 ± 1.5 nm, whereas that of the conjugates was 30-50 ± 0.5 nm. The use of SeNPs to increase the bioavailability of S...
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International Association of Physical Chemists (IAPC)
2021
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oai:doaj.org-article:3dbfe4e4718c454aafe8dd1657455df92021-11-15T10:03:43ZSynthesis of silymarin−selenium nanoparticle conjugate and examination of its biological activity in vitro10.5599/admet.10231848-7718https://doaj.org/article/3dbfe4e4718c454aafe8dd1657455df92021-11-01T00:00:00Zhttps://pub.iapchem.org/ojs/index.php/admet/article/view/1023https://doaj.org/toc/1848-7718 Silymarin (Sil) was conjugated to selenium nanoparticles (SeNPs) to increase Sil bioavailability. The conjugates were monodisperse; the average diameter of the native SeNPs was ~ 20-50 ± 1.5 nm, whereas that of the conjugates was 30-50 ± 0.5 nm. The use of SeNPs to increase the bioavailability of Syl was examined with the MH-22a, EPNT-5, HeLa, Hep-2, and SPEV-2 cell lines. The EPNT-5 (glioblastoma) cells were the most sensitive to the conjugates compared to the conjugate-free control. The conjugates increased the activity of cellular dehydrogenases and promoted the penetration of Sil into the intracellular space. Possibly, SeNPs play the main part in Sil penetration of cells and Sil penetration is not associated with phagocytosis. Thus, SeNPs are promising for use as a Sil carrier and as protective antigens. Sergey StaroverovSergey KozlovAlexander FominKonstantin GabalovVitaliy KhanadeevDmitry SoldatovIvan DomnitskyLev DykmanSergey V. AkchurinOlga GuliyInternational Association of Physical Chemists (IAPC)articleTherapeutics. PharmacologyRM1-950ENADMET and DMPK (2021) |
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Therapeutics. Pharmacology RM1-950 |
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Therapeutics. Pharmacology RM1-950 Sergey Staroverov Sergey Kozlov Alexander Fomin Konstantin Gabalov Vitaliy Khanadeev Dmitry Soldatov Ivan Domnitsky Lev Dykman Sergey V. Akchurin Olga Guliy Synthesis of silymarin−selenium nanoparticle conjugate and examination of its biological activity in vitro |
| description |
Silymarin (Sil) was conjugated to selenium nanoparticles (SeNPs) to increase Sil bioavailability. The conjugates were monodisperse; the average diameter of the native SeNPs was ~ 20-50 ± 1.5 nm, whereas that of the conjugates was 30-50 ± 0.5 nm. The use of SeNPs to increase the bioavailability of Syl was examined with the MH-22a, EPNT-5, HeLa, Hep-2, and SPEV-2 cell lines. The EPNT-5 (glioblastoma) cells were the most sensitive to the conjugates compared to the conjugate-free control. The conjugates increased the activity of cellular dehydrogenases and promoted the penetration of Sil into the intracellular space. Possibly, SeNPs play the main part in Sil penetration of cells and Sil penetration is not associated with phagocytosis. Thus, SeNPs are promising for use as a Sil carrier and as protective antigens.
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| format |
article |
| author |
Sergey Staroverov Sergey Kozlov Alexander Fomin Konstantin Gabalov Vitaliy Khanadeev Dmitry Soldatov Ivan Domnitsky Lev Dykman Sergey V. Akchurin Olga Guliy |
| author_facet |
Sergey Staroverov Sergey Kozlov Alexander Fomin Konstantin Gabalov Vitaliy Khanadeev Dmitry Soldatov Ivan Domnitsky Lev Dykman Sergey V. Akchurin Olga Guliy |
| author_sort |
Sergey Staroverov |
| title |
Synthesis of silymarin−selenium nanoparticle conjugate and examination of its biological activity in vitro |
| title_short |
Synthesis of silymarin−selenium nanoparticle conjugate and examination of its biological activity in vitro |
| title_full |
Synthesis of silymarin−selenium nanoparticle conjugate and examination of its biological activity in vitro |
| title_fullStr |
Synthesis of silymarin−selenium nanoparticle conjugate and examination of its biological activity in vitro |
| title_full_unstemmed |
Synthesis of silymarin−selenium nanoparticle conjugate and examination of its biological activity in vitro |
| title_sort |
synthesis of silymarin−selenium nanoparticle conjugate and examination of its biological activity in vitro |
| publisher |
International Association of Physical Chemists (IAPC) |
| publishDate |
2021 |
| url |
https://doaj.org/article/3dbfe4e4718c454aafe8dd1657455df9 |
| work_keys_str_mv |
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1718428428380667904 |