Healthy Sleep Associated With Lower Risk of Hypertension Regardless of Genetic Risk: A Population-Based Cohort Study

Background: Hypertension is a leading contributor to the global burden of disease and to mortality. The combined effects of sleep factors on the risk of hypertension are unclear. We aimed to evaluate the effect of combined sleep factors on the risk of hypertension and to explore whether this associa...

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Autores principales:	Zhi-Hao Li, Qing-Mei Huang, Xiang Gao, Vincent C. H. Chung, Pei-Dong Zhang, Dong Shen, Xi-Ru Zhang, Wen-Fang Zhong, Dan Liu, Pei-Liang Chen, Qing Chen, Miao-Chun Cai, Xin Cheng, Hai-Lian Yang, Wei-Qi Song, Xian-Bo Wu, Virginia Byers Kraus, Chen Mao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	sleep genetic risk hypertension cohort study epidemiology Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/3dc1bf9fa6e74c4e8de0aa6265c8c076
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spelling	oai:doaj.org-article:3dc1bf9fa6e74c4e8de0aa6265c8c0762021-11-18T07:19:52ZHealthy Sleep Associated With Lower Risk of Hypertension Regardless of Genetic Risk: A Population-Based Cohort Study2297-055X10.3389/fcvm.2021.769130https://doaj.org/article/3dc1bf9fa6e74c4e8de0aa6265c8c0762021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.769130/fullhttps://doaj.org/toc/2297-055XBackground: Hypertension is a leading contributor to the global burden of disease and to mortality. The combined effects of sleep factors on the risk of hypertension are unclear. We aimed to evaluate the effect of combined sleep factors on the risk of hypertension and to explore whether this association is independent of genetic risk.Methods: This population-based prospective cohort study included 170,378 participants from the UK Biobank study. We conducted a healthy sleep score based on a combination of major five sleep factors and a genetic risk score based on 118 risk variants. Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).Results: A total of 170,378 participants were included. Compared to participants with a healthy sleep score of 0–1, those with healthy sleep scores of 2 (HR, 0.90; 95% CI, 0.83–0.98), 3 (HR, 0.81; 95% CI, 0.75–0.88), 4 (HR, 0.74; 95% CI, 0.68–0.81), or 5 (HR, 0.67; 95% CI, 0.59–0.77) had increasingly lower risks of hypertension (P for trend <0.001). Participants with high genetic risk and an unfavorable sleep pattern had a 1.80-fold greater risk of hypertension than participants with low genetic risk and a favorable sleep pattern. The association between sleep patterns and hypertension persisted in subgroup analysis, stratified by the genetic risk. Nearly 18.2% of hypertension events in this cohort could be attributed to unfavorable sleep pattern.Conclusions: Favorable sleep pattern was associated with a low risk of hypertension, regardless of genetic risk. These findings highlight the potential of sleep interventions to reduce risk of hypertension across entire populations.Zhi-Hao LiQing-Mei HuangXiang GaoVincent C. H. ChungPei-Dong ZhangDong ShenXi-Ru ZhangWen-Fang ZhongDan LiuPei-Liang ChenQing ChenMiao-Chun CaiXin ChengHai-Lian YangWei-Qi SongXian-Bo WuVirginia Byers KrausChen MaoChen MaoFrontiers Media S.A.articlesleepgenetic riskhypertensioncohort studyepidemiologyDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sleep genetic risk hypertension cohort study epidemiology Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	sleep genetic risk hypertension cohort study epidemiology Diseases of the circulatory (Cardiovascular) system RC666-701 Zhi-Hao Li Qing-Mei Huang Xiang Gao Vincent C. H. Chung Pei-Dong Zhang Dong Shen Xi-Ru Zhang Wen-Fang Zhong Dan Liu Pei-Liang Chen Qing Chen Miao-Chun Cai Xin Cheng Hai-Lian Yang Wei-Qi Song Xian-Bo Wu Virginia Byers Kraus Chen Mao Chen Mao Healthy Sleep Associated With Lower Risk of Hypertension Regardless of Genetic Risk: A Population-Based Cohort Study
description	Background: Hypertension is a leading contributor to the global burden of disease and to mortality. The combined effects of sleep factors on the risk of hypertension are unclear. We aimed to evaluate the effect of combined sleep factors on the risk of hypertension and to explore whether this association is independent of genetic risk.Methods: This population-based prospective cohort study included 170,378 participants from the UK Biobank study. We conducted a healthy sleep score based on a combination of major five sleep factors and a genetic risk score based on 118 risk variants. Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).Results: A total of 170,378 participants were included. Compared to participants with a healthy sleep score of 0–1, those with healthy sleep scores of 2 (HR, 0.90; 95% CI, 0.83–0.98), 3 (HR, 0.81; 95% CI, 0.75–0.88), 4 (HR, 0.74; 95% CI, 0.68–0.81), or 5 (HR, 0.67; 95% CI, 0.59–0.77) had increasingly lower risks of hypertension (P for trend <0.001). Participants with high genetic risk and an unfavorable sleep pattern had a 1.80-fold greater risk of hypertension than participants with low genetic risk and a favorable sleep pattern. The association between sleep patterns and hypertension persisted in subgroup analysis, stratified by the genetic risk. Nearly 18.2% of hypertension events in this cohort could be attributed to unfavorable sleep pattern.Conclusions: Favorable sleep pattern was associated with a low risk of hypertension, regardless of genetic risk. These findings highlight the potential of sleep interventions to reduce risk of hypertension across entire populations.
format	article
author	Zhi-Hao Li Qing-Mei Huang Xiang Gao Vincent C. H. Chung Pei-Dong Zhang Dong Shen Xi-Ru Zhang Wen-Fang Zhong Dan Liu Pei-Liang Chen Qing Chen Miao-Chun Cai Xin Cheng Hai-Lian Yang Wei-Qi Song Xian-Bo Wu Virginia Byers Kraus Chen Mao Chen Mao
author_facet	Zhi-Hao Li Qing-Mei Huang Xiang Gao Vincent C. H. Chung Pei-Dong Zhang Dong Shen Xi-Ru Zhang Wen-Fang Zhong Dan Liu Pei-Liang Chen Qing Chen Miao-Chun Cai Xin Cheng Hai-Lian Yang Wei-Qi Song Xian-Bo Wu Virginia Byers Kraus Chen Mao Chen Mao
author_sort	Zhi-Hao Li
title	Healthy Sleep Associated With Lower Risk of Hypertension Regardless of Genetic Risk: A Population-Based Cohort Study
title_short	Healthy Sleep Associated With Lower Risk of Hypertension Regardless of Genetic Risk: A Population-Based Cohort Study
title_full	Healthy Sleep Associated With Lower Risk of Hypertension Regardless of Genetic Risk: A Population-Based Cohort Study
title_fullStr	Healthy Sleep Associated With Lower Risk of Hypertension Regardless of Genetic Risk: A Population-Based Cohort Study
title_full_unstemmed	Healthy Sleep Associated With Lower Risk of Hypertension Regardless of Genetic Risk: A Population-Based Cohort Study
title_sort	healthy sleep associated with lower risk of hypertension regardless of genetic risk: a population-based cohort study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3dc1bf9fa6e74c4e8de0aa6265c8c076
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Healthy Sleep Associated With Lower Risk of Hypertension Regardless of Genetic Risk: A Population-Based Cohort Study

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