Structure of the substrate-engaged SecA-SecY protein translocation machine

Proteins are translocated across membranes through the Sec61/SecY channel. Here, the authors present the structure of a translocating peptide chain trapped inside the SecA-SecY complex which suggests how peptides are actively moved through the channel.

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Detalles Bibliográficos
Autores principales: Chengying Ma, Xiaofei Wu, Dongjie Sun, Eunyong Park, Marco A. Catipovic, Tom A. Rapoport, Ning Gao, Long Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/3dc527858b7e406c878e3ab10c154820
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Descripción
Sumario:Proteins are translocated across membranes through the Sec61/SecY channel. Here, the authors present the structure of a translocating peptide chain trapped inside the SecA-SecY complex which suggests how peptides are actively moved through the channel.