Structure of the substrate-engaged SecA-SecY protein translocation machine

Proteins are translocated across membranes through the Sec61/SecY channel. Here, the authors present the structure of a translocating peptide chain trapped inside the SecA-SecY complex which suggests how peptides are actively moved through the channel.

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Autores principales:	Chengying Ma, Xiaofei Wu, Dongjie Sun, Eunyong Park, Marco A. Catipovic, Tom A. Rapoport, Ning Gao, Long Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3dc527858b7e406c878e3ab10c154820
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id	oai:doaj.org-article:3dc527858b7e406c878e3ab10c154820
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spelling	oai:doaj.org-article:3dc527858b7e406c878e3ab10c1548202021-12-02T17:01:52ZStructure of the substrate-engaged SecA-SecY protein translocation machine10.1038/s41467-019-10918-22041-1723https://doaj.org/article/3dc527858b7e406c878e3ab10c1548202019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10918-2https://doaj.org/toc/2041-1723Proteins are translocated across membranes through the Sec61/SecY channel. Here, the authors present the structure of a translocating peptide chain trapped inside the SecA-SecY complex which suggests how peptides are actively moved through the channel.Chengying MaXiaofei WuDongjie SunEunyong ParkMarco A. CatipovicTom A. RapoportNing GaoLong LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chengying Ma Xiaofei Wu Dongjie Sun Eunyong Park Marco A. Catipovic Tom A. Rapoport Ning Gao Long Li Structure of the substrate-engaged SecA-SecY protein translocation machine
description	Proteins are translocated across membranes through the Sec61/SecY channel. Here, the authors present the structure of a translocating peptide chain trapped inside the SecA-SecY complex which suggests how peptides are actively moved through the channel.
format	article
author	Chengying Ma Xiaofei Wu Dongjie Sun Eunyong Park Marco A. Catipovic Tom A. Rapoport Ning Gao Long Li
author_facet	Chengying Ma Xiaofei Wu Dongjie Sun Eunyong Park Marco A. Catipovic Tom A. Rapoport Ning Gao Long Li
author_sort	Chengying Ma
title	Structure of the substrate-engaged SecA-SecY protein translocation machine
title_short	Structure of the substrate-engaged SecA-SecY protein translocation machine
title_full	Structure of the substrate-engaged SecA-SecY protein translocation machine
title_fullStr	Structure of the substrate-engaged SecA-SecY protein translocation machine
title_full_unstemmed	Structure of the substrate-engaged SecA-SecY protein translocation machine
title_sort	structure of the substrate-engaged seca-secy protein translocation machine
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3dc527858b7e406c878e3ab10c154820
work_keys_str_mv	AT chengyingma structureofthesubstrateengagedsecasecyproteintranslocationmachine AT xiaofeiwu structureofthesubstrateengagedsecasecyproteintranslocationmachine AT dongjiesun structureofthesubstrateengagedsecasecyproteintranslocationmachine AT eunyongpark structureofthesubstrateengagedsecasecyproteintranslocationmachine AT marcoacatipovic structureofthesubstrateengagedsecasecyproteintranslocationmachine AT tomarapoport structureofthesubstrateengagedsecasecyproteintranslocationmachine AT ninggao structureofthesubstrateengagedsecasecyproteintranslocationmachine AT longli structureofthesubstrateengagedsecasecyproteintranslocationmachine
_version_	1718382022470139904

Structure of the substrate-engaged SecA-SecY protein translocation machine

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