IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease

Transcription factors directing T cell fate are induced by instructive signals such as cytokines. Here the authors show that IL-15 promotes Foxp3 and inhibits RORγt expression in CD4 T cells, and that IL-15 is critical to suppress colitis by maintaining the Treg to Th1/Th17 ratio in a mouse model.

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Autores principales:	Milena J. Tosiek, Laurence Fiette, Sary El Daker, Gérard Eberl, Antonio A. Freitas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3dc67ae9efce4f0fb99eca4bbf7248f0
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spelling	oai:doaj.org-article:3dc67ae9efce4f0fb99eca4bbf7248f02021-12-02T16:57:01ZIL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease10.1038/ncomms108882041-1723https://doaj.org/article/3dc67ae9efce4f0fb99eca4bbf7248f02016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10888https://doaj.org/toc/2041-1723Transcription factors directing T cell fate are induced by instructive signals such as cytokines. Here the authors show that IL-15 promotes Foxp3 and inhibits RORγt expression in CD4 T cells, and that IL-15 is critical to suppress colitis by maintaining the Treg to Th1/Th17 ratio in a mouse model.Milena J. TosiekLaurence FietteSary El DakerGérard EberlAntonio A. FreitasNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Milena J. Tosiek Laurence Fiette Sary El Daker Gérard Eberl Antonio A. Freitas IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease
description	Transcription factors directing T cell fate are induced by instructive signals such as cytokines. Here the authors show that IL-15 promotes Foxp3 and inhibits RORγt expression in CD4 T cells, and that IL-15 is critical to suppress colitis by maintaining the Treg to Th1/Th17 ratio in a mouse model.
format	article
author	Milena J. Tosiek Laurence Fiette Sary El Daker Gérard Eberl Antonio A. Freitas
author_facet	Milena J. Tosiek Laurence Fiette Sary El Daker Gérard Eberl Antonio A. Freitas
author_sort	Milena J. Tosiek
title	IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease
title_short	IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease
title_full	IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease
title_fullStr	IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease
title_full_unstemmed	IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease
title_sort	il-15-dependent balance between foxp3 and rorγt expression impacts inflammatory bowel disease
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3dc67ae9efce4f0fb99eca4bbf7248f0
work_keys_str_mv	AT milenajtosiek il15dependentbalancebetweenfoxp3androrgtexpressionimpactsinflammatoryboweldisease AT laurencefiette il15dependentbalancebetweenfoxp3androrgtexpressionimpactsinflammatoryboweldisease AT saryeldaker il15dependentbalancebetweenfoxp3androrgtexpressionimpactsinflammatoryboweldisease AT gerardeberl il15dependentbalancebetweenfoxp3androrgtexpressionimpactsinflammatoryboweldisease AT antonioafreitas il15dependentbalancebetweenfoxp3androrgtexpressionimpactsinflammatoryboweldisease
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IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease

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