Comparison of Tamoxifen and Clomiphene on Ovulation and Pregnancy Rates in Polycystic Ovary Syndrome Patients

BACKGROUND AND OBJECTIVE: Ovulation disorders are a common cause of infertility in women. A common cause of anovulation is polycystic ovarian syndrome. Anti-estrogens agents such as clomiphene citrate and tamoxifen citrate are used as first line treatment in polycystic ovary syndrome patients. About...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	S Esmaeilzadeh, M Zeinalzadeh, SH Tehrani, A BIJANI
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2009
Materias:	infertility polycystic ovarian syndrome tamoxifen citrate clomiphene citrate ovulation pregnancy Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3dc926e2486a410ba7bb13fc8e60f51e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3dc926e2486a410ba7bb13fc8e60f51e
record_format	dspace
spelling	oai:doaj.org-article:3dc926e2486a410ba7bb13fc8e60f51e2021-11-10T09:02:34ZComparison of Tamoxifen and Clomiphene on Ovulation and Pregnancy Rates in Polycystic Ovary Syndrome Patients1561-41072251-7170https://doaj.org/article/3dc926e2486a410ba7bb13fc8e60f51e2009-04-01T00:00:00Zhttp://jbums.org/article-1-3146-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Ovulation disorders are a common cause of infertility in women. A common cause of anovulation is polycystic ovarian syndrome. Anti-estrogens agents such as clomiphene citrate and tamoxifen citrate are used as first line treatment in polycystic ovary syndrome patients. About 25% of patients may resistant to clomiphene. The aim of this study was to compare the rates of ovulation and pregnancy between tamoxifen citrate and clomiphene citrate in polycystic ovary patients.METHODS: This randomized controlled trial study was performed on 150 polycystic ovary syndrome patients referred to Fatemeh Zahra infertile center and Mehregan hospital in Babol, Iran during 2005 and 2006. Patients randomly divided into two groups and stimulation with clomiphene and tamoxifen on cycle days 2-6 was done. On first cycle, patients were treated with clomiphene (100 mg) and tamoxifen (40 mg) and on the next cycle because of no ovulation or pregnancy patients underwent clomiphene (150mg) and tamoxifen (60mg). Ovulation and pregnancy rates were compared in two groups.FINDINGS: The rate of ovulation in the tamoxifen 40 mg (TMX) group was 41 of 75 (54.7%) and in the clomiphene citrate 100 mg (CC) group was 40 of 75 (53.3%). The rate of ovulation in the TMX group (60mg) was 60 of 73 (82.2%) and in the CC (150mg) was 44 of 70 (62.9%) (p=0.014). There were 5 pregnancies in the TMX group (6.7%) and 10 pregnancies in the CC group (13.3%) that there was not significant difference between two groups.CONCLUSION: According to the results of this study, for increasing ovulation rate and pregnancy in polycystic ovary syndrome patients who were resistant to clomiphene, tamoxifen can be used.S Esmaeilzadeh,M ZeinalzadehSH TehraniA BIJANIBabol University of Medical Sciencesarticleinfertilitypolycystic ovarian syndrometamoxifen citrateclomiphene citrateovulationpregnancyMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 11, Iss 1, Pp 14-18 (2009)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	infertility polycystic ovarian syndrome tamoxifen citrate clomiphene citrate ovulation pregnancy Medicine R Medicine (General) R5-920
spellingShingle	infertility polycystic ovarian syndrome tamoxifen citrate clomiphene citrate ovulation pregnancy Medicine R Medicine (General) R5-920 S Esmaeilzadeh, M Zeinalzadeh SH Tehrani A BIJANI Comparison of Tamoxifen and Clomiphene on Ovulation and Pregnancy Rates in Polycystic Ovary Syndrome Patients
description	BACKGROUND AND OBJECTIVE: Ovulation disorders are a common cause of infertility in women. A common cause of anovulation is polycystic ovarian syndrome. Anti-estrogens agents such as clomiphene citrate and tamoxifen citrate are used as first line treatment in polycystic ovary syndrome patients. About 25% of patients may resistant to clomiphene. The aim of this study was to compare the rates of ovulation and pregnancy between tamoxifen citrate and clomiphene citrate in polycystic ovary patients.METHODS: This randomized controlled trial study was performed on 150 polycystic ovary syndrome patients referred to Fatemeh Zahra infertile center and Mehregan hospital in Babol, Iran during 2005 and 2006. Patients randomly divided into two groups and stimulation with clomiphene and tamoxifen on cycle days 2-6 was done. On first cycle, patients were treated with clomiphene (100 mg) and tamoxifen (40 mg) and on the next cycle because of no ovulation or pregnancy patients underwent clomiphene (150mg) and tamoxifen (60mg). Ovulation and pregnancy rates were compared in two groups.FINDINGS: The rate of ovulation in the tamoxifen 40 mg (TMX) group was 41 of 75 (54.7%) and in the clomiphene citrate 100 mg (CC) group was 40 of 75 (53.3%). The rate of ovulation in the TMX group (60mg) was 60 of 73 (82.2%) and in the CC (150mg) was 44 of 70 (62.9%) (p=0.014). There were 5 pregnancies in the TMX group (6.7%) and 10 pregnancies in the CC group (13.3%) that there was not significant difference between two groups.CONCLUSION: According to the results of this study, for increasing ovulation rate and pregnancy in polycystic ovary syndrome patients who were resistant to clomiphene, tamoxifen can be used.
format	article
author	S Esmaeilzadeh, M Zeinalzadeh SH Tehrani A BIJANI
author_facet	S Esmaeilzadeh, M Zeinalzadeh SH Tehrani A BIJANI
author_sort	S Esmaeilzadeh,
title	Comparison of Tamoxifen and Clomiphene on Ovulation and Pregnancy Rates in Polycystic Ovary Syndrome Patients
title_short	Comparison of Tamoxifen and Clomiphene on Ovulation and Pregnancy Rates in Polycystic Ovary Syndrome Patients
title_full	Comparison of Tamoxifen and Clomiphene on Ovulation and Pregnancy Rates in Polycystic Ovary Syndrome Patients
title_fullStr	Comparison of Tamoxifen and Clomiphene on Ovulation and Pregnancy Rates in Polycystic Ovary Syndrome Patients
title_full_unstemmed	Comparison of Tamoxifen and Clomiphene on Ovulation and Pregnancy Rates in Polycystic Ovary Syndrome Patients
title_sort	comparison of tamoxifen and clomiphene on ovulation and pregnancy rates in polycystic ovary syndrome patients
publisher	Babol University of Medical Sciences
publishDate	2009
url	https://doaj.org/article/3dc926e2486a410ba7bb13fc8e60f51e
work_keys_str_mv	AT sesmaeilzadeh comparisonoftamoxifenandclomipheneonovulationandpregnancyratesinpolycysticovarysyndromepatients AT mzeinalzadeh comparisonoftamoxifenandclomipheneonovulationandpregnancyratesinpolycysticovarysyndromepatients AT shtehrani comparisonoftamoxifenandclomipheneonovulationandpregnancyratesinpolycysticovarysyndromepatients AT abijani comparisonoftamoxifenandclomipheneonovulationandpregnancyratesinpolycysticovarysyndromepatients
_version_	1718440273541857280

Comparison of Tamoxifen and Clomiphene on Ovulation and Pregnancy Rates in Polycystic Ovary Syndrome Patients

Ejemplares similares