Th17 effector cells support B cell responses outside of germinal centres.

Th17 cells are pro-inflammatory CD4⁺T cells, which are important in immune responses against fungal pathogens and extracellular bacteria and have also been implicated in various autoimmune syndromes. However, their role in supporting B cell responses in these scenarios remains unclear, representing...

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Autores principales:	Agapitos Patakas, Robert A Benson, David R Withers, Paola Conigliaro, Iain B McInnes, James M Brewer, Paul Garside
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3dca14ce508f4cf8b94d4bdaa30d1d92
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spelling	oai:doaj.org-article:3dca14ce508f4cf8b94d4bdaa30d1d922021-11-18T08:08:27ZTh17 effector cells support B cell responses outside of germinal centres.1932-620310.1371/journal.pone.0049715https://doaj.org/article/3dca14ce508f4cf8b94d4bdaa30d1d922012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23166752/?tool=EBIhttps://doaj.org/toc/1932-6203Th17 cells are pro-inflammatory CD4⁺T cells, which are important in immune responses against fungal pathogens and extracellular bacteria and have also been implicated in various autoimmune syndromes. However, their role in supporting B cell responses in these scenarios remains unclear, representing a significant lapse in our understanding of the role Th17 play in vaccine responses and the regulation of autoimmunity. We employed T cell and B cell receptor transgenic mice specific for model antigens, and adoptive transfer approaches that allowed the tracking of cognate B and T cells in situ and ex vivo using immunological methods. We have found that T cells activated under Th17 polarising conditions have a greater capacity to provide cognate B cell help compared with Th1 polarised populations, supporting higher expansion of antigen specific B cells and enhanced antibody titres. This advantage is associated with the increased persistence of Th17 polarised cells in areas of the lymph nodes where they can provide help (i.e. the B cell follicles). Also the Th17 cells are characterised by their higher expression of ICOS, a costimulatory molecule important for B cell help. Surprisingly, contrary to published reports, Th17 cells were not detected inside germinal centres, although they were found in close proximity to cognate B cells in the follicle early in the genesis of the humoral immune response. These data indicate that, Th17 cells have a more significant role earlier in the initiation/development of the germinal centre response and/or germinal centre-independent events, consistent with their early effector status.Agapitos PatakasRobert A BensonDavid R WithersPaola ConigliaroIain B McInnesJames M BrewerPaul GarsidePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49715 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Agapitos Patakas Robert A Benson David R Withers Paola Conigliaro Iain B McInnes James M Brewer Paul Garside Th17 effector cells support B cell responses outside of germinal centres.
description	Th17 cells are pro-inflammatory CD4⁺T cells, which are important in immune responses against fungal pathogens and extracellular bacteria and have also been implicated in various autoimmune syndromes. However, their role in supporting B cell responses in these scenarios remains unclear, representing a significant lapse in our understanding of the role Th17 play in vaccine responses and the regulation of autoimmunity. We employed T cell and B cell receptor transgenic mice specific for model antigens, and adoptive transfer approaches that allowed the tracking of cognate B and T cells in situ and ex vivo using immunological methods. We have found that T cells activated under Th17 polarising conditions have a greater capacity to provide cognate B cell help compared with Th1 polarised populations, supporting higher expansion of antigen specific B cells and enhanced antibody titres. This advantage is associated with the increased persistence of Th17 polarised cells in areas of the lymph nodes where they can provide help (i.e. the B cell follicles). Also the Th17 cells are characterised by their higher expression of ICOS, a costimulatory molecule important for B cell help. Surprisingly, contrary to published reports, Th17 cells were not detected inside germinal centres, although they were found in close proximity to cognate B cells in the follicle early in the genesis of the humoral immune response. These data indicate that, Th17 cells have a more significant role earlier in the initiation/development of the germinal centre response and/or germinal centre-independent events, consistent with their early effector status.
format	article
author	Agapitos Patakas Robert A Benson David R Withers Paola Conigliaro Iain B McInnes James M Brewer Paul Garside
author_facet	Agapitos Patakas Robert A Benson David R Withers Paola Conigliaro Iain B McInnes James M Brewer Paul Garside
author_sort	Agapitos Patakas
title	Th17 effector cells support B cell responses outside of germinal centres.
title_short	Th17 effector cells support B cell responses outside of germinal centres.
title_full	Th17 effector cells support B cell responses outside of germinal centres.
title_fullStr	Th17 effector cells support B cell responses outside of germinal centres.
title_full_unstemmed	Th17 effector cells support B cell responses outside of germinal centres.
title_sort	th17 effector cells support b cell responses outside of germinal centres.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/3dca14ce508f4cf8b94d4bdaa30d1d92
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Th17 effector cells support B cell responses outside of germinal centres.

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