Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death

Inflammatory caspases restrict microbial growth by inducing cytokine production and pyroptosis, but other caspase-induced mechanisms are thought to contribute. Here the authors use time-lapse microscopy of single cells to show that caspase1/11 has anti-Salmonella functions that occur in advance of c...

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Autores principales:	Teresa L. M. Thurston, Sophie A. Matthews, Elliott Jennings, Eric Alix, Feng Shao, Avinash R. Shenoy, Mark A. Birrell, David W. Holden
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3dcaf1a910524de0b958aea81b142880
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spelling	oai:doaj.org-article:3dcaf1a910524de0b958aea81b1428802021-12-02T17:32:51ZGrowth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death10.1038/ncomms132922041-1723https://doaj.org/article/3dcaf1a910524de0b958aea81b1428802016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13292https://doaj.org/toc/2041-1723Inflammatory caspases restrict microbial growth by inducing cytokine production and pyroptosis, but other caspase-induced mechanisms are thought to contribute. Here the authors use time-lapse microscopy of single cells to show that caspase1/11 has anti-Salmonella functions that occur in advance of cell death induction.Teresa L. M. ThurstonSophie A. MatthewsElliott JenningsEric AlixFeng ShaoAvinash R. ShenoyMark A. BirrellDavid W. HoldenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Teresa L. M. Thurston Sophie A. Matthews Elliott Jennings Eric Alix Feng Shao Avinash R. Shenoy Mark A. Birrell David W. Holden Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death
description	Inflammatory caspases restrict microbial growth by inducing cytokine production and pyroptosis, but other caspase-induced mechanisms are thought to contribute. Here the authors use time-lapse microscopy of single cells to show that caspase1/11 has anti-Salmonella functions that occur in advance of cell death induction.
format	article
author	Teresa L. M. Thurston Sophie A. Matthews Elliott Jennings Eric Alix Feng Shao Avinash R. Shenoy Mark A. Birrell David W. Holden
author_facet	Teresa L. M. Thurston Sophie A. Matthews Elliott Jennings Eric Alix Feng Shao Avinash R. Shenoy Mark A. Birrell David W. Holden
author_sort	Teresa L. M. Thurston
title	Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death
title_short	Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death
title_full	Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death
title_fullStr	Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death
title_full_unstemmed	Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death
title_sort	growth inhibition of cytosolic salmonella by caspase-1 and caspase-11 precedes host cell death
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3dcaf1a910524de0b958aea81b142880
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Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death

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