Mirror neurons are modulated by grip force and reward expectation in the sensorimotor cortices (S1, M1, PMd, PMv)

Abstract Mirror Neurons (MNs) respond similarly when primates make or observe grasping movements. Recent work indicates that reward expectation influences rostral M1 (rM1) during manual, observational, and Brain Machine Interface (BMI) reaching movements. Previous work showed MNs are modulated by su...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Md Moin Uddin Atique, Joseph Thachil Francis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3dcb2c60e8ff4590bdefff4c1b2fc457
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3dcb2c60e8ff4590bdefff4c1b2fc457
record_format	dspace
spelling	oai:doaj.org-article:3dcb2c60e8ff4590bdefff4c1b2fc4572021-12-02T18:49:34ZMirror neurons are modulated by grip force and reward expectation in the sensorimotor cortices (S1, M1, PMd, PMv)10.1038/s41598-021-95536-z2045-2322https://doaj.org/article/3dcb2c60e8ff4590bdefff4c1b2fc4572021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95536-zhttps://doaj.org/toc/2045-2322Abstract Mirror Neurons (MNs) respond similarly when primates make or observe grasping movements. Recent work indicates that reward expectation influences rostral M1 (rM1) during manual, observational, and Brain Machine Interface (BMI) reaching movements. Previous work showed MNs are modulated by subjective value. Here we expand on the above work utilizing two non-human primates (NHPs), one male Macaca Radiata (NHP S) and one female Macaca Mulatta (NHP P), that were trained to perform a cued reward level isometric grip-force task, where the NHPs had to apply visually cued grip-force to move and transport a virtual object. We found a population of (S1 area 1–2, rM1, PMd, PMv) units that significantly represented grip-force during manual and observational trials. We found the neural representation of visually cued force was similar during observational trials and manual trials for the same units; however, the representation was weaker during observational trials. Comparing changes in neural time lags between manual and observational tasks indicated that a subpopulation fit the standard MN definition of observational neural activity lagging the visual information. Neural activity in (S1 areas 1–2, rM1, PMd, PMv) significantly represented force and reward expectation. In summary, we present results indicating that sensorimotor cortices have MNs for visually cued force and value.Md Moin Uddin AtiqueJoseph Thachil FrancisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Md Moin Uddin Atique Joseph Thachil Francis Mirror neurons are modulated by grip force and reward expectation in the sensorimotor cortices (S1, M1, PMd, PMv)
description	Abstract Mirror Neurons (MNs) respond similarly when primates make or observe grasping movements. Recent work indicates that reward expectation influences rostral M1 (rM1) during manual, observational, and Brain Machine Interface (BMI) reaching movements. Previous work showed MNs are modulated by subjective value. Here we expand on the above work utilizing two non-human primates (NHPs), one male Macaca Radiata (NHP S) and one female Macaca Mulatta (NHP P), that were trained to perform a cued reward level isometric grip-force task, where the NHPs had to apply visually cued grip-force to move and transport a virtual object. We found a population of (S1 area 1–2, rM1, PMd, PMv) units that significantly represented grip-force during manual and observational trials. We found the neural representation of visually cued force was similar during observational trials and manual trials for the same units; however, the representation was weaker during observational trials. Comparing changes in neural time lags between manual and observational tasks indicated that a subpopulation fit the standard MN definition of observational neural activity lagging the visual information. Neural activity in (S1 areas 1–2, rM1, PMd, PMv) significantly represented force and reward expectation. In summary, we present results indicating that sensorimotor cortices have MNs for visually cued force and value.
format	article
author	Md Moin Uddin Atique Joseph Thachil Francis
author_facet	Md Moin Uddin Atique Joseph Thachil Francis
author_sort	Md Moin Uddin Atique
title	Mirror neurons are modulated by grip force and reward expectation in the sensorimotor cortices (S1, M1, PMd, PMv)
title_short	Mirror neurons are modulated by grip force and reward expectation in the sensorimotor cortices (S1, M1, PMd, PMv)
title_full	Mirror neurons are modulated by grip force and reward expectation in the sensorimotor cortices (S1, M1, PMd, PMv)
title_fullStr	Mirror neurons are modulated by grip force and reward expectation in the sensorimotor cortices (S1, M1, PMd, PMv)
title_full_unstemmed	Mirror neurons are modulated by grip force and reward expectation in the sensorimotor cortices (S1, M1, PMd, PMv)
title_sort	mirror neurons are modulated by grip force and reward expectation in the sensorimotor cortices (s1, m1, pmd, pmv)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3dcb2c60e8ff4590bdefff4c1b2fc457
work_keys_str_mv	AT mdmoinuddinatique mirrorneuronsaremodulatedbygripforceandrewardexpectationinthesensorimotorcorticess1m1pmdpmv AT josephthachilfrancis mirrorneuronsaremodulatedbygripforceandrewardexpectationinthesensorimotorcorticess1m1pmdpmv
_version_	1718377556061716480

Mirror neurons are modulated by grip force and reward expectation in the sensorimotor cortices (S1, M1, PMd, PMv)

Ejemplares similares