A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses

A novel human coronavirus prompted considerable worry at the end of the year 2019. Now, it represents a significant global health and economic burden. The newly emerged coronavirus disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the primary reason for the COVID-...

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Autores principales:	Aaya Nassar, Ibrahim M. Ibrahim, Fatma G. Amin, Merna Magdy, Ahmed M. Elgharib, Eman B. Azzam, Filopateer Nasser, Kirllos Yousry, Israa M. Shamkh, Samah M. Mahdy, Abdo A. Elfiky
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	human coronavirus cell receptor viral entry spike SARS-CoV-2 COVID-19 Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/3dcb759497ed42ca9f328f9614c578bd
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spelling	oai:doaj.org-article:3dcb759497ed42ca9f328f9614c578bd2021-11-11T18:27:53ZA Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses10.3390/molecules262164551420-3049https://doaj.org/article/3dcb759497ed42ca9f328f9614c578bd2021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6455https://doaj.org/toc/1420-3049A novel human coronavirus prompted considerable worry at the end of the year 2019. Now, it represents a significant global health and economic burden. The newly emerged coronavirus disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the primary reason for the COVID-19 global pandemic. According to recent global figures, COVID-19 has caused approximately 243.3 million illnesses and 4.9 million deaths. Several human cell receptors are involved in the virus identification of the host cells and entering them. Hence, understanding how the virus binds to host-cell receptors is crucial for developing antiviral treatments and vaccines. The current work aimed to determine the multiple host-cell receptors that bind with SARS-CoV-2 and other human coronaviruses for the purpose of cell entry. Extensive research is needed using neutralizing antibodies, natural chemicals, and therapeutic peptides to target those host-cell receptors in extremely susceptible individuals. More research is needed to map SARS-CoV-2 cell entry pathways in order to identify potential viral inhibitors.Aaya NassarIbrahim M. IbrahimFatma G. AminMerna MagdyAhmed M. ElgharibEman B. AzzamFilopateer NasserKirllos YousryIsraa M. ShamkhSamah M. MahdyAbdo A. ElfikyMDPI AGarticlehuman coronaviruscell receptorviral entryspikeSARS-CoV-2COVID-19Organic chemistryQD241-441ENMolecules, Vol 26, Iss 6455, p 6455 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	human coronavirus cell receptor viral entry spike SARS-CoV-2 COVID-19 Organic chemistry QD241-441
spellingShingle	human coronavirus cell receptor viral entry spike SARS-CoV-2 COVID-19 Organic chemistry QD241-441 Aaya Nassar Ibrahim M. Ibrahim Fatma G. Amin Merna Magdy Ahmed M. Elgharib Eman B. Azzam Filopateer Nasser Kirllos Yousry Israa M. Shamkh Samah M. Mahdy Abdo A. Elfiky A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses
description	A novel human coronavirus prompted considerable worry at the end of the year 2019. Now, it represents a significant global health and economic burden. The newly emerged coronavirus disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the primary reason for the COVID-19 global pandemic. According to recent global figures, COVID-19 has caused approximately 243.3 million illnesses and 4.9 million deaths. Several human cell receptors are involved in the virus identification of the host cells and entering them. Hence, understanding how the virus binds to host-cell receptors is crucial for developing antiviral treatments and vaccines. The current work aimed to determine the multiple host-cell receptors that bind with SARS-CoV-2 and other human coronaviruses for the purpose of cell entry. Extensive research is needed using neutralizing antibodies, natural chemicals, and therapeutic peptides to target those host-cell receptors in extremely susceptible individuals. More research is needed to map SARS-CoV-2 cell entry pathways in order to identify potential viral inhibitors.
format	article
author	Aaya Nassar Ibrahim M. Ibrahim Fatma G. Amin Merna Magdy Ahmed M. Elgharib Eman B. Azzam Filopateer Nasser Kirllos Yousry Israa M. Shamkh Samah M. Mahdy Abdo A. Elfiky
author_facet	Aaya Nassar Ibrahim M. Ibrahim Fatma G. Amin Merna Magdy Ahmed M. Elgharib Eman B. Azzam Filopateer Nasser Kirllos Yousry Israa M. Shamkh Samah M. Mahdy Abdo A. Elfiky
author_sort	Aaya Nassar
title	A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses
title_short	A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses
title_full	A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses
title_fullStr	A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses
title_full_unstemmed	A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses
title_sort	review of human coronaviruses’ receptors: the host-cell targets for the crown bearing viruses
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3dcb759497ed42ca9f328f9614c578bd
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A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses

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