Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection

Control over T. gondii infection in the brain involves microglial cells, but how these cells execute this control is not clear. Here the authors show that unlike IL-1β dominant macrophages, microglia are primed for gasdermin-D-dependent IL-1α production that is critical for protection against T. gon...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Samantha J. Batista, Katherine M. Still, David Johanson, Jeremy A. Thompson, Carleigh A. OʼBrien, John R. Lukens, Tajie H. Harris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3dcd849f496a440e86d76c688c091fee
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3dcd849f496a440e86d76c688c091fee
record_format	dspace
spelling	oai:doaj.org-article:3dcd849f496a440e86d76c688c091fee2021-12-02T16:26:32ZGasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection10.1038/s41467-020-17491-z2041-1723https://doaj.org/article/3dcd849f496a440e86d76c688c091fee2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17491-zhttps://doaj.org/toc/2041-1723Control over T. gondii infection in the brain involves microglial cells, but how these cells execute this control is not clear. Here the authors show that unlike IL-1β dominant macrophages, microglia are primed for gasdermin-D-dependent IL-1α production that is critical for protection against T. gondii infection.Samantha J. BatistaKatherine M. StillDavid JohansonJeremy A. ThompsonCarleigh A. OʼBrienJohn R. LukensTajie H. HarrisNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Samantha J. Batista Katherine M. Still David Johanson Jeremy A. Thompson Carleigh A. OʼBrien John R. Lukens Tajie H. Harris Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection
description	Control over T. gondii infection in the brain involves microglial cells, but how these cells execute this control is not clear. Here the authors show that unlike IL-1β dominant macrophages, microglia are primed for gasdermin-D-dependent IL-1α production that is critical for protection against T. gondii infection.
format	article
author	Samantha J. Batista Katherine M. Still David Johanson Jeremy A. Thompson Carleigh A. OʼBrien John R. Lukens Tajie H. Harris
author_facet	Samantha J. Batista Katherine M. Still David Johanson Jeremy A. Thompson Carleigh A. OʼBrien John R. Lukens Tajie H. Harris
author_sort	Samantha J. Batista
title	Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection
title_short	Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection
title_full	Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection
title_fullStr	Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection
title_full_unstemmed	Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection
title_sort	gasdermin-d-dependent il-1α release from microglia promotes protective immunity during chronic toxoplasma gondii infection
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3dcd849f496a440e86d76c688c091fee
work_keys_str_mv	AT samanthajbatista gasderminddependentil1areleasefrommicrogliapromotesprotectiveimmunityduringchronictoxoplasmagondiiinfection AT katherinemstill gasderminddependentil1areleasefrommicrogliapromotesprotectiveimmunityduringchronictoxoplasmagondiiinfection AT davidjohanson gasderminddependentil1areleasefrommicrogliapromotesprotectiveimmunityduringchronictoxoplasmagondiiinfection AT jeremyathompson gasderminddependentil1areleasefrommicrogliapromotesprotectiveimmunityduringchronictoxoplasmagondiiinfection AT carleighaoʼbrien gasderminddependentil1areleasefrommicrogliapromotesprotectiveimmunityduringchronictoxoplasmagondiiinfection AT johnrlukens gasderminddependentil1areleasefrommicrogliapromotesprotectiveimmunityduringchronictoxoplasmagondiiinfection AT tajiehharris gasderminddependentil1areleasefrommicrogliapromotesprotectiveimmunityduringchronictoxoplasmagondiiinfection
_version_	1718383985416994816

Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection

Ejemplares similares