Network dynamics-based cancer panel stratification for systemic prediction of anticancer drug response

Genomic alterations underlie the variability of drug responses between cancers, but our mechanistic understanding is limited. Here the authors use the p53 network to study how rewiring of signalling networks by genomic alterations impact their dynamic response to pharmacological perturbation.

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Detalles Bibliográficos
Autores principales: Minsoo Choi, Jue Shi, Yanting Zhu, Ruizhen Yang, Kwang-Hyun Cho
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/3dd24c28dfe74c3bac266661964850eb
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Sumario:Genomic alterations underlie the variability of drug responses between cancers, but our mechanistic understanding is limited. Here the authors use the p53 network to study how rewiring of signalling networks by genomic alterations impact their dynamic response to pharmacological perturbation.