Network dynamics-based cancer panel stratification for systemic prediction of anticancer drug response

Genomic alterations underlie the variability of drug responses between cancers, but our mechanistic understanding is limited. Here the authors use the p53 network to study how rewiring of signalling networks by genomic alterations impact their dynamic response to pharmacological perturbation.

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Autores principales:	Minsoo Choi, Jue Shi, Yanting Zhu, Ruizhen Yang, Kwang-Hyun Cho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3dd24c28dfe74c3bac266661964850eb
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spelling	oai:doaj.org-article:3dd24c28dfe74c3bac266661964850eb2021-12-02T15:38:34ZNetwork dynamics-based cancer panel stratification for systemic prediction of anticancer drug response10.1038/s41467-017-02160-52041-1723https://doaj.org/article/3dd24c28dfe74c3bac266661964850eb2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02160-5https://doaj.org/toc/2041-1723Genomic alterations underlie the variability of drug responses between cancers, but our mechanistic understanding is limited. Here the authors use the p53 network to study how rewiring of signalling networks by genomic alterations impact their dynamic response to pharmacological perturbation.Minsoo ChoiJue ShiYanting ZhuRuizhen YangKwang-Hyun ChoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Minsoo Choi Jue Shi Yanting Zhu Ruizhen Yang Kwang-Hyun Cho Network dynamics-based cancer panel stratification for systemic prediction of anticancer drug response
description	Genomic alterations underlie the variability of drug responses between cancers, but our mechanistic understanding is limited. Here the authors use the p53 network to study how rewiring of signalling networks by genomic alterations impact their dynamic response to pharmacological perturbation.
format	article
author	Minsoo Choi Jue Shi Yanting Zhu Ruizhen Yang Kwang-Hyun Cho
author_facet	Minsoo Choi Jue Shi Yanting Zhu Ruizhen Yang Kwang-Hyun Cho
author_sort	Minsoo Choi
title	Network dynamics-based cancer panel stratification for systemic prediction of anticancer drug response
title_short	Network dynamics-based cancer panel stratification for systemic prediction of anticancer drug response
title_full	Network dynamics-based cancer panel stratification for systemic prediction of anticancer drug response
title_fullStr	Network dynamics-based cancer panel stratification for systemic prediction of anticancer drug response
title_full_unstemmed	Network dynamics-based cancer panel stratification for systemic prediction of anticancer drug response
title_sort	network dynamics-based cancer panel stratification for systemic prediction of anticancer drug response
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3dd24c28dfe74c3bac266661964850eb
work_keys_str_mv	AT minsoochoi networkdynamicsbasedcancerpanelstratificationforsystemicpredictionofanticancerdrugresponse AT jueshi networkdynamicsbasedcancerpanelstratificationforsystemicpredictionofanticancerdrugresponse AT yantingzhu networkdynamicsbasedcancerpanelstratificationforsystemicpredictionofanticancerdrugresponse AT ruizhenyang networkdynamicsbasedcancerpanelstratificationforsystemicpredictionofanticancerdrugresponse AT kwanghyuncho networkdynamicsbasedcancerpanelstratificationforsystemicpredictionofanticancerdrugresponse
_version_	1718386105426903040

Network dynamics-based cancer panel stratification for systemic prediction of anticancer drug response

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