Multiple roles of H2A.Z in regulating promoter chromatin architecture in human cells

Histone variant H2A.Z has been suggested to contribute to the regulation of promoter accessibility. Here, the authors present high-depth maps of the position and accessibility of H2A.Z-containing nucleosomes for human Pol II promoters and provide evidence that H2A.Z has multiple and distinct roles i...

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Autores principales:	Lauren Cole, Sebastian Kurscheid, Maxim Nekrasov, Renae Domaschenz, Daniel L. Vera, Jonathan H. Dennis, David J. Tremethick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3dd420dcdf0c40f78d943734cd5023b8
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spelling	oai:doaj.org-article:3dd420dcdf0c40f78d943734cd5023b82021-12-02T16:49:12ZMultiple roles of H2A.Z in regulating promoter chromatin architecture in human cells10.1038/s41467-021-22688-x2041-1723https://doaj.org/article/3dd420dcdf0c40f78d943734cd5023b82021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22688-xhttps://doaj.org/toc/2041-1723Histone variant H2A.Z has been suggested to contribute to the regulation of promoter accessibility. Here, the authors present high-depth maps of the position and accessibility of H2A.Z-containing nucleosomes for human Pol II promoters and provide evidence that H2A.Z has multiple and distinct roles in regulating gene expression dependent upon its location in a promoter.Lauren ColeSebastian KurscheidMaxim NekrasovRenae DomaschenzDaniel L. VeraJonathan H. DennisDavid J. TremethickNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lauren Cole Sebastian Kurscheid Maxim Nekrasov Renae Domaschenz Daniel L. Vera Jonathan H. Dennis David J. Tremethick Multiple roles of H2A.Z in regulating promoter chromatin architecture in human cells
description	Histone variant H2A.Z has been suggested to contribute to the regulation of promoter accessibility. Here, the authors present high-depth maps of the position and accessibility of H2A.Z-containing nucleosomes for human Pol II promoters and provide evidence that H2A.Z has multiple and distinct roles in regulating gene expression dependent upon its location in a promoter.
format	article
author	Lauren Cole Sebastian Kurscheid Maxim Nekrasov Renae Domaschenz Daniel L. Vera Jonathan H. Dennis David J. Tremethick
author_facet	Lauren Cole Sebastian Kurscheid Maxim Nekrasov Renae Domaschenz Daniel L. Vera Jonathan H. Dennis David J. Tremethick
author_sort	Lauren Cole
title	Multiple roles of H2A.Z in regulating promoter chromatin architecture in human cells
title_short	Multiple roles of H2A.Z in regulating promoter chromatin architecture in human cells
title_full	Multiple roles of H2A.Z in regulating promoter chromatin architecture in human cells
title_fullStr	Multiple roles of H2A.Z in regulating promoter chromatin architecture in human cells
title_full_unstemmed	Multiple roles of H2A.Z in regulating promoter chromatin architecture in human cells
title_sort	multiple roles of h2a.z in regulating promoter chromatin architecture in human cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3dd420dcdf0c40f78d943734cd5023b8
work_keys_str_mv	AT laurencole multiplerolesofh2azinregulatingpromoterchromatinarchitectureinhumancells AT sebastiankurscheid multiplerolesofh2azinregulatingpromoterchromatinarchitectureinhumancells AT maximnekrasov multiplerolesofh2azinregulatingpromoterchromatinarchitectureinhumancells AT renaedomaschenz multiplerolesofh2azinregulatingpromoterchromatinarchitectureinhumancells AT daniellvera multiplerolesofh2azinregulatingpromoterchromatinarchitectureinhumancells AT jonathanhdennis multiplerolesofh2azinregulatingpromoterchromatinarchitectureinhumancells AT davidjtremethick multiplerolesofh2azinregulatingpromoterchromatinarchitectureinhumancells
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Multiple roles of H2A.Z in regulating promoter chromatin architecture in human cells

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