Melatonin level as a risk factor for age-related macular degeneration

Background. The current trend towards an increase in age-related macular degeneration (AMD) incidence rate in the population, including the working-age population, with a possible loss of professional activity, indicates the need for early preclinical identification of risk groups, timely prevention...

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Autores principales:	N. S. Khodzhaev, A. D. Chuprov, S. M. Kim, O. V. Marshinskaya, T. V. Kazakova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	age-related macular degeneration melatonin risk factors blood serum lacrimal fluid Science Q
Acceso en línea:	https://doaj.org/article/3dd50415a6e047fdbafd70db4dce5a67
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spelling	oai:doaj.org-article:3dd50415a6e047fdbafd70db4dce5a672021-11-23T06:14:46ZMelatonin level as a risk factor for age-related macular degeneration2541-94202587-959610.29413/ABS.2021-6.3.14https://doaj.org/article/3dd50415a6e047fdbafd70db4dce5a672021-08-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2857https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. The current trend towards an increase in age-related macular degeneration (AMD) incidence rate in the population, including the working-age population, with a possible loss of professional activity, indicates the need for early preclinical identification of risk groups, timely prevention and treatment. In the prevention and treatment of AMD, the prospect of using melatonin is being actively discussed.Aim: to analyze serum and tear fluid levels of melatonin in patients with AMD and study their correlation with risk factors.Materials and methods. In the course of the study, two groups were formed: the main group - patients with non-exudative AMD and senile cataract (n = 40) and the reference group - conditionally healthy patients without AMD and cataract (n = 20). Patients of both groups were surveyed to identify risk factors for AMD. The content of melatonin in blood serum and lacrimal fluid was determined by enzyme-linked immunosorbent assay using the Melatonin ELISA Kit (USA).Results. In the course of the study, it was found that the concentration of melatonin in blood serum and tear fluid in patients with AMD was significantly lower than in patients of the reference group (p <0.05). Serum and tear fluid melatonin levels depend on the following factors: age, body mass index (BMI), arterial hypertension, eye color, insomnia, and night work. It is possible that the local determination of melatonin in the lacrimal fluid can be a biomarker in the determination of ophthalmic pathological conditions.Conclusion. The obtained results can be used as recommendations for clarifying individual regimens for the use of melatonin, especially in the treatment of patients with AMD.N. S. KhodzhaevA. D. ChuprovS. M. KimO. V. MarshinskayaT. V. KazakovaScientific Сentre for Family Health and Human Reproduction Problemsarticleage-related macular degenerationmelatoninrisk factorsblood serumlacrimal fluidScienceQRUActa Biomedica Scientifica, Vol 6, Iss 3, Pp 133-141 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	age-related macular degeneration melatonin risk factors blood serum lacrimal fluid Science Q
spellingShingle	age-related macular degeneration melatonin risk factors blood serum lacrimal fluid Science Q N. S. Khodzhaev A. D. Chuprov S. M. Kim O. V. Marshinskaya T. V. Kazakova Melatonin level as a risk factor for age-related macular degeneration
description	Background. The current trend towards an increase in age-related macular degeneration (AMD) incidence rate in the population, including the working-age population, with a possible loss of professional activity, indicates the need for early preclinical identification of risk groups, timely prevention and treatment. In the prevention and treatment of AMD, the prospect of using melatonin is being actively discussed.Aim: to analyze serum and tear fluid levels of melatonin in patients with AMD and study their correlation with risk factors.Materials and methods. In the course of the study, two groups were formed: the main group - patients with non-exudative AMD and senile cataract (n = 40) and the reference group - conditionally healthy patients without AMD and cataract (n = 20). Patients of both groups were surveyed to identify risk factors for AMD. The content of melatonin in blood serum and lacrimal fluid was determined by enzyme-linked immunosorbent assay using the Melatonin ELISA Kit (USA).Results. In the course of the study, it was found that the concentration of melatonin in blood serum and tear fluid in patients with AMD was significantly lower than in patients of the reference group (p <0.05). Serum and tear fluid melatonin levels depend on the following factors: age, body mass index (BMI), arterial hypertension, eye color, insomnia, and night work. It is possible that the local determination of melatonin in the lacrimal fluid can be a biomarker in the determination of ophthalmic pathological conditions.Conclusion. The obtained results can be used as recommendations for clarifying individual regimens for the use of melatonin, especially in the treatment of patients with AMD.
format	article
author	N. S. Khodzhaev A. D. Chuprov S. M. Kim O. V. Marshinskaya T. V. Kazakova
author_facet	N. S. Khodzhaev A. D. Chuprov S. M. Kim O. V. Marshinskaya T. V. Kazakova
author_sort	N. S. Khodzhaev
title	Melatonin level as a risk factor for age-related macular degeneration
title_short	Melatonin level as a risk factor for age-related macular degeneration
title_full	Melatonin level as a risk factor for age-related macular degeneration
title_fullStr	Melatonin level as a risk factor for age-related macular degeneration
title_full_unstemmed	Melatonin level as a risk factor for age-related macular degeneration
title_sort	melatonin level as a risk factor for age-related macular degeneration
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/3dd50415a6e047fdbafd70db4dce5a67
work_keys_str_mv	AT nskhodzhaev melatoninlevelasariskfactorforagerelatedmaculardegeneration AT adchuprov melatoninlevelasariskfactorforagerelatedmaculardegeneration AT smkim melatoninlevelasariskfactorforagerelatedmaculardegeneration AT ovmarshinskaya melatoninlevelasariskfactorforagerelatedmaculardegeneration AT tvkazakova melatoninlevelasariskfactorforagerelatedmaculardegeneration
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Melatonin level as a risk factor for age-related macular degeneration

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