Efficacy of carbomer sodium hyaluronate trehalose vs hyaluronic acid to improve tear film instability and ocular surface discomfort after cataract surgery

L Caretti,1 A La Gloria Valerio,1 R Piermarocchi,1 G Badin,1 G Verzola,1 F Masarà,1 T Scalora,2 C Monterosso31Ophthalmology Unit, Santa Maria della Misericordia Hospital, Rovigo, Italy; 2Neurosciences Department, Ophthalmology Unit, University of Padua, Padua, Italy; 3Ophthalmology Unit,...

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Autores principales:	Caretti L, La Gloria Valerio A, Piermarocchi R, Badin G, Verzola G, Masarà F, Scalora T, Monterosso C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	cataract surgery tear film instability artificial tears trehalose Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/3dd59c49c554418bbb18f58c95aafcf6
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spelling	oai:doaj.org-article:3dd59c49c554418bbb18f58c95aafcf62021-12-02T02:11:04ZEfficacy of carbomer sodium hyaluronate trehalose vs hyaluronic acid to improve tear film instability and ocular surface discomfort after cataract surgery1177-5483https://doaj.org/article/3dd59c49c554418bbb18f58c95aafcf62019-07-01T00:00:00Zhttps://www.dovepress.com/efficacy-of-carbomer-sodium-hyaluronate-trehalose-vs-hyaluronic-acid-t-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483L Caretti,1 A La Gloria Valerio,1 R Piermarocchi,1 G Badin,1 G Verzola,1 F Masarà,1 T Scalora,2 C Monterosso31Ophthalmology Unit, Santa Maria della Misericordia Hospital, Rovigo, Italy; 2Neurosciences Department, Ophthalmology Unit, University of Padua, Padua, Italy; 3Ophthalmology Unit, Dell’Angelo Hospital, Meste, ItalyPurpose: To evaluate the effects of carbomer sodium hyaluronate trehalose (CHT) and sodium hyaluronate eye drops on tear film stability and ocular discomfort after cataract surgery.Setting: Santa Maria della Misericordia Hospital, Rovigo, Italy.Design: Prospective randomized case-control study.Patients and methods: This study enrolled sixty patients scheduled for unilateral cataract surgery. After phacoemulsification, subjects received carbomer sodium hyaluronate trehalose (trehalose group) or sodium hyaluronate tears (HG group) substitute and were assessed through objective (break up time, corneal and conjunctival staining) and subjective (OSDI questionnaire) clinical evaluations after a two times a day topical administration. Outcome measures were collected preoperatively (baseline), one week (day 7) and 1 month (day 30) after surgery. Finally, each patient was asked to give his personal treatment satisfaction score.Results: Trehalose group showed a steeper break up time (BUT) increase compared to patient treated with hyaluronic acid (P<0.001). OSDI questionnaire presented a opposite trend, trehalose patients evidenced a significantly major improvement (P<0.001), and in seven days mean values reduced by more than three times. Fluorescein staining reduction was documented with both treatments, although there was no statistically significant difference between groups. Finally CHT resulted in a significantly greater global satisfaction score (P<0.001).Conclusions: CHT was effective and well tolerated in reducing dry eye disease symptoms and improving the clinical outcome after cataract surgery. On some parameters (BUT, OSDI), this new formulation was more effective than commonly used sodium hyaluronate in treating ocular irritation and tear film alterations.Keywords: cataract surgery, tear film instability, artificial tears, trehaloseCaretti LLa Gloria Valerio APiermarocchi RBadin GVerzola GMasarà FScalora TMonterosso CDove Medical Pressarticlecataract surgerytear film instabilityartificial tearstrehaloseOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1157-1163 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	cataract surgery tear film instability artificial tears trehalose Ophthalmology RE1-994
spellingShingle	cataract surgery tear film instability artificial tears trehalose Ophthalmology RE1-994 Caretti L La Gloria Valerio A Piermarocchi R Badin G Verzola G Masarà F Scalora T Monterosso C Efficacy of carbomer sodium hyaluronate trehalose vs hyaluronic acid to improve tear film instability and ocular surface discomfort after cataract surgery
description	L Caretti,1 A La Gloria Valerio,1 R Piermarocchi,1 G Badin,1 G Verzola,1 F Masarà,1 T Scalora,2 C Monterosso31Ophthalmology Unit, Santa Maria della Misericordia Hospital, Rovigo, Italy; 2Neurosciences Department, Ophthalmology Unit, University of Padua, Padua, Italy; 3Ophthalmology Unit, Dell’Angelo Hospital, Meste, ItalyPurpose: To evaluate the effects of carbomer sodium hyaluronate trehalose (CHT) and sodium hyaluronate eye drops on tear film stability and ocular discomfort after cataract surgery.Setting: Santa Maria della Misericordia Hospital, Rovigo, Italy.Design: Prospective randomized case-control study.Patients and methods: This study enrolled sixty patients scheduled for unilateral cataract surgery. After phacoemulsification, subjects received carbomer sodium hyaluronate trehalose (trehalose group) or sodium hyaluronate tears (HG group) substitute and were assessed through objective (break up time, corneal and conjunctival staining) and subjective (OSDI questionnaire) clinical evaluations after a two times a day topical administration. Outcome measures were collected preoperatively (baseline), one week (day 7) and 1 month (day 30) after surgery. Finally, each patient was asked to give his personal treatment satisfaction score.Results: Trehalose group showed a steeper break up time (BUT) increase compared to patient treated with hyaluronic acid (P<0.001). OSDI questionnaire presented a opposite trend, trehalose patients evidenced a significantly major improvement (P<0.001), and in seven days mean values reduced by more than three times. Fluorescein staining reduction was documented with both treatments, although there was no statistically significant difference between groups. Finally CHT resulted in a significantly greater global satisfaction score (P<0.001).Conclusions: CHT was effective and well tolerated in reducing dry eye disease symptoms and improving the clinical outcome after cataract surgery. On some parameters (BUT, OSDI), this new formulation was more effective than commonly used sodium hyaluronate in treating ocular irritation and tear film alterations.Keywords: cataract surgery, tear film instability, artificial tears, trehalose
format	article
author	Caretti L La Gloria Valerio A Piermarocchi R Badin G Verzola G Masarà F Scalora T Monterosso C
author_facet	Caretti L La Gloria Valerio A Piermarocchi R Badin G Verzola G Masarà F Scalora T Monterosso C
author_sort	Caretti L
title	Efficacy of carbomer sodium hyaluronate trehalose vs hyaluronic acid to improve tear film instability and ocular surface discomfort after cataract surgery
title_short	Efficacy of carbomer sodium hyaluronate trehalose vs hyaluronic acid to improve tear film instability and ocular surface discomfort after cataract surgery
title_full	Efficacy of carbomer sodium hyaluronate trehalose vs hyaluronic acid to improve tear film instability and ocular surface discomfort after cataract surgery
title_fullStr	Efficacy of carbomer sodium hyaluronate trehalose vs hyaluronic acid to improve tear film instability and ocular surface discomfort after cataract surgery
title_full_unstemmed	Efficacy of carbomer sodium hyaluronate trehalose vs hyaluronic acid to improve tear film instability and ocular surface discomfort after cataract surgery
title_sort	efficacy of carbomer sodium hyaluronate trehalose vs hyaluronic acid to improve tear film instability and ocular surface discomfort after cataract surgery
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/3dd59c49c554418bbb18f58c95aafcf6
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Efficacy of carbomer sodium hyaluronate trehalose vs hyaluronic acid to improve tear film instability and ocular surface discomfort after cataract surgery

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