Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome
Membrane-disrupting agents that selectively target virus versus host membranes could potentially be potent antivirals. Here the authors incorporate a decoy virus receptor into a nanodisc and show that it ruptures the viral membrane at low pH and traps viral RNAs in the endolysosome for degradation.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/3dd9feb19abe4cd5836438ceb64097b5 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:3dd9feb19abe4cd5836438ceb64097b5 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:3dd9feb19abe4cd5836438ceb64097b52021-12-02T15:35:26ZVirucidal nano-perforator of viral membrane trapping viral RNAs in the endosome10.1038/s41467-018-08138-12041-1723https://doaj.org/article/3dd9feb19abe4cd5836438ceb64097b52019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08138-1https://doaj.org/toc/2041-1723Membrane-disrupting agents that selectively target virus versus host membranes could potentially be potent antivirals. Here the authors incorporate a decoy virus receptor into a nanodisc and show that it ruptures the viral membrane at low pH and traps viral RNAs in the endolysosome for degradation.Byoungjae KongSeokoh MoonYuna KimPaul HeoYounghun JungSeok-Hyeon YuJinhyo ChungChoongjin BanYong Ho KimPaul KimBeom Jeung HwangWoo-Jae ChungYeon-Kyun ShinBaik Lin SeongDae-Hyuk KweonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Byoungjae Kong Seokoh Moon Yuna Kim Paul Heo Younghun Jung Seok-Hyeon Yu Jinhyo Chung Choongjin Ban Yong Ho Kim Paul Kim Beom Jeung Hwang Woo-Jae Chung Yeon-Kyun Shin Baik Lin Seong Dae-Hyuk Kweon Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome |
| description |
Membrane-disrupting agents that selectively target virus versus host membranes could potentially be potent antivirals. Here the authors incorporate a decoy virus receptor into a nanodisc and show that it ruptures the viral membrane at low pH and traps viral RNAs in the endolysosome for degradation. |
| format |
article |
| author |
Byoungjae Kong Seokoh Moon Yuna Kim Paul Heo Younghun Jung Seok-Hyeon Yu Jinhyo Chung Choongjin Ban Yong Ho Kim Paul Kim Beom Jeung Hwang Woo-Jae Chung Yeon-Kyun Shin Baik Lin Seong Dae-Hyuk Kweon |
| author_facet |
Byoungjae Kong Seokoh Moon Yuna Kim Paul Heo Younghun Jung Seok-Hyeon Yu Jinhyo Chung Choongjin Ban Yong Ho Kim Paul Kim Beom Jeung Hwang Woo-Jae Chung Yeon-Kyun Shin Baik Lin Seong Dae-Hyuk Kweon |
| author_sort |
Byoungjae Kong |
| title |
Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome |
| title_short |
Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome |
| title_full |
Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome |
| title_fullStr |
Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome |
| title_full_unstemmed |
Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome |
| title_sort |
virucidal nano-perforator of viral membrane trapping viral rnas in the endosome |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/3dd9feb19abe4cd5836438ceb64097b5 |
| work_keys_str_mv |
AT byoungjaekong virucidalnanoperforatorofviralmembranetrappingviralrnasintheendosome AT seokohmoon virucidalnanoperforatorofviralmembranetrappingviralrnasintheendosome AT yunakim virucidalnanoperforatorofviralmembranetrappingviralrnasintheendosome AT paulheo virucidalnanoperforatorofviralmembranetrappingviralrnasintheendosome AT younghunjung virucidalnanoperforatorofviralmembranetrappingviralrnasintheendosome AT seokhyeonyu virucidalnanoperforatorofviralmembranetrappingviralrnasintheendosome AT jinhyochung virucidalnanoperforatorofviralmembranetrappingviralrnasintheendosome AT choongjinban virucidalnanoperforatorofviralmembranetrappingviralrnasintheendosome AT yonghokim virucidalnanoperforatorofviralmembranetrappingviralrnasintheendosome AT paulkim virucidalnanoperforatorofviralmembranetrappingviralrnasintheendosome AT beomjeunghwang virucidalnanoperforatorofviralmembranetrappingviralrnasintheendosome AT woojaechung virucidalnanoperforatorofviralmembranetrappingviralrnasintheendosome AT yeonkyunshin virucidalnanoperforatorofviralmembranetrappingviralrnasintheendosome AT baiklinseong virucidalnanoperforatorofviralmembranetrappingviralrnasintheendosome AT daehyukkweon virucidalnanoperforatorofviralmembranetrappingviralrnasintheendosome |
| _version_ |
1718386526590599168 |