The effect of acetaminophen nanoparticles on liver toxicity in a rat model

Esmaeil Biazar1, S Mahdi Rezayat2, Naser Montazeri1, Khalil Pourshamsian1, Reza Zeinali3, Azadeh Asefnejad3, Mehdi Rahimi3, Mohammadmajid Zadehzare3, Mehran Mahmoudi3, Rohollah Mazinani3, Mehdi Ziaei31Department of Chemistry, Islamic Azad University, Tonekabon Branch, Mazandaran, Iran; 2Department o...

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Autores principales:	Esmaeil Biazar, S Mahdi Rezayat, Naser Montazeri, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3ddb1e4ce6d347c88da6744f3e462f4e
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spelling	oai:doaj.org-article:3ddb1e4ce6d347c88da6744f3e462f4e2021-12-02T02:46:49ZThe effect of acetaminophen nanoparticles on liver toxicity in a rat model1176-91141178-2013https://doaj.org/article/3ddb1e4ce6d347c88da6744f3e462f4e2010-03-01T00:00:00Zhttp://www.dovepress.com/the-effect-of-acetaminophen-nanoparticles-on-liver-toxicity-in-a-rat-m-a4149https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Esmaeil Biazar1, S Mahdi Rezayat2, Naser Montazeri1, Khalil Pourshamsian1, Reza Zeinali3, Azadeh Asefnejad3, Mehdi Rahimi3, Mohammadmajid Zadehzare3, Mehran Mahmoudi3, Rohollah Mazinani3, Mehdi Ziaei31Department of Chemistry, Islamic Azad University, Tonekabon Branch, Mazandaran, Iran; 2Department of Pharmacology, School of Medicine, Tehran University of Medical Science, Tehran, Iran; 3Biomedical Engineering, Islamic Azad University, Research and Science Branch, Tehran, IranAbstract: Acetaminophen, a pain-reliever, is one of the most widely used medications in the world. Acetaminophen with normal dosage is considered a nontoxic drug for therapeutic applications, but when taken at overdose levels it produces liver damage in human and various animal species. By a high energy mechanically activated method, we produced acetaminophen in a nanometer crystalline size (24 nm). Forty-eight hours after injection of crystalline particles with normal and reduced size of our drug, the effect of liver toxicity was compared by determination of liver transferase enzymes such as alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase (ALT). These enzymes were examined by routine colorimetric methods using commercial kits and pathologic investigations. Statistical analysis and pathological figures indicated that ALT delivery and toxicity in reduced size acetaminophen was significantly reduced when compared with normal size acetaminophen. Pathology figures exhibited reduced necrosis effects, especially the confluent necrosis, in the central part of the lobule in the reduced size acetaminophen samples when compared with the normal samples.Keywords: acetaminophen, size reduction, pathological and enzymatic investigations, toxicity Esmaeil BiazarS Mahdi RezayatNaser Montazeriet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 197-201 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Esmaeil Biazar S Mahdi Rezayat Naser Montazeri et al The effect of acetaminophen nanoparticles on liver toxicity in a rat model
description	Esmaeil Biazar1, S Mahdi Rezayat2, Naser Montazeri1, Khalil Pourshamsian1, Reza Zeinali3, Azadeh Asefnejad3, Mehdi Rahimi3, Mohammadmajid Zadehzare3, Mehran Mahmoudi3, Rohollah Mazinani3, Mehdi Ziaei31Department of Chemistry, Islamic Azad University, Tonekabon Branch, Mazandaran, Iran; 2Department of Pharmacology, School of Medicine, Tehran University of Medical Science, Tehran, Iran; 3Biomedical Engineering, Islamic Azad University, Research and Science Branch, Tehran, IranAbstract: Acetaminophen, a pain-reliever, is one of the most widely used medications in the world. Acetaminophen with normal dosage is considered a nontoxic drug for therapeutic applications, but when taken at overdose levels it produces liver damage in human and various animal species. By a high energy mechanically activated method, we produced acetaminophen in a nanometer crystalline size (24 nm). Forty-eight hours after injection of crystalline particles with normal and reduced size of our drug, the effect of liver toxicity was compared by determination of liver transferase enzymes such as alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase (ALT). These enzymes were examined by routine colorimetric methods using commercial kits and pathologic investigations. Statistical analysis and pathological figures indicated that ALT delivery and toxicity in reduced size acetaminophen was significantly reduced when compared with normal size acetaminophen. Pathology figures exhibited reduced necrosis effects, especially the confluent necrosis, in the central part of the lobule in the reduced size acetaminophen samples when compared with the normal samples.Keywords: acetaminophen, size reduction, pathological and enzymatic investigations, toxicity
format	article
author	Esmaeil Biazar S Mahdi Rezayat Naser Montazeri et al
author_facet	Esmaeil Biazar S Mahdi Rezayat Naser Montazeri et al
author_sort	Esmaeil Biazar
title	The effect of acetaminophen nanoparticles on liver toxicity in a rat model
title_short	The effect of acetaminophen nanoparticles on liver toxicity in a rat model
title_full	The effect of acetaminophen nanoparticles on liver toxicity in a rat model
title_fullStr	The effect of acetaminophen nanoparticles on liver toxicity in a rat model
title_full_unstemmed	The effect of acetaminophen nanoparticles on liver toxicity in a rat model
title_sort	effect of acetaminophen nanoparticles on liver toxicity in a rat model
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/3ddb1e4ce6d347c88da6744f3e462f4e
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The effect of acetaminophen nanoparticles on liver toxicity in a rat model

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