Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection

Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection

Chondroitin sulfate proteoglycan 4 (CSPG4) is a potential receptor for C. difficile toxin B (TcdB) during C. difficile infections (CDIs). Here, the cryo-EM structure of a TcdB–CSPG4 complex and CDI mouse models offer insights into CSPG4 role in CDIs and suggest a therapeutic strategy targeting TcdB....

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Autores principales: Peng Chen, Ji Zeng, Zheng Liu, Hatim Thaker, Siyu Wang, Songhai Tian, Jie Zhang, Liang Tao, Craig B. Gutierrez, Li Xing, Ralf Gerhard, Lan Huang, Min Dong, Rongsheng Jin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/3de58ad2a56840ca9197090b475a1c57
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spelling oai:doaj.org-article:3de58ad2a56840ca9197090b475a1c572021-12-02T16:04:16ZStructural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection10.1038/s41467-021-23878-32041-1723https://doaj.org/article/3de58ad2a56840ca9197090b475a1c572021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23878-3https://doaj.org/toc/2041-1723Chondroitin sulfate proteoglycan 4 (CSPG4) is a potential receptor for C. difficile toxin B (TcdB) during C. difficile infections (CDIs). Here, the cryo-EM structure of a TcdB–CSPG4 complex and CDI mouse models offer insights into CSPG4 role in CDIs and suggest a therapeutic strategy targeting TcdB.Peng ChenJi ZengZheng LiuHatim ThakerSiyu WangSonghai TianJie ZhangLiang TaoCraig B. GutierrezLi XingRalf GerhardLan HuangMin DongRongsheng JinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Peng Chen
Ji Zeng
Zheng Liu
Hatim Thaker
Siyu Wang
Songhai Tian
Jie Zhang
Liang Tao
Craig B. Gutierrez
Li Xing
Ralf Gerhard
Lan Huang
Min Dong
Rongsheng Jin
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
description Chondroitin sulfate proteoglycan 4 (CSPG4) is a potential receptor for C. difficile toxin B (TcdB) during C. difficile infections (CDIs). Here, the cryo-EM structure of a TcdB–CSPG4 complex and CDI mouse models offer insights into CSPG4 role in CDIs and suggest a therapeutic strategy targeting TcdB.
format article
author Peng Chen
Ji Zeng
Zheng Liu
Hatim Thaker
Siyu Wang
Songhai Tian
Jie Zhang
Liang Tao
Craig B. Gutierrez
Li Xing
Ralf Gerhard
Lan Huang
Min Dong
Rongsheng Jin
author_facet Peng Chen
Ji Zeng
Zheng Liu
Hatim Thaker
Siyu Wang
Songhai Tian
Jie Zhang
Liang Tao
Craig B. Gutierrez
Li Xing
Ralf Gerhard
Lan Huang
Min Dong
Rongsheng Jin
author_sort Peng Chen
title Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
title_short Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
title_full Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
title_fullStr Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
title_full_unstemmed Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
title_sort structural basis for cspg4 as a receptor for tcdb and a therapeutic target in clostridioides difficile infection
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/3de58ad2a56840ca9197090b475a1c57
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