Disrupted functional brain connectivity in partial epilepsy: a resting-state fMRI study.

Examining the spontaneous activity to understand the neural mechanism of brain disorder is a focus in recent resting-state fMRI. In the current study, to investigate the alteration of brain functional connectivity in partial epilepsy in a systematical way, two levels of analyses (functional connecti...

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Autores principales:	Cheng Luo, Chuan Qiu, Zhiwei Guo, Jiajia Fang, Qifu Li, Xu Lei, Yang Xia, Yongxiu Lai, Qiyong Gong, Dong Zhou, Dezhong Yao
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3de9ef3691eb4ddda255ba7e2ecb9e67
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spelling	oai:doaj.org-article:3de9ef3691eb4ddda255ba7e2ecb9e672021-11-18T07:36:27ZDisrupted functional brain connectivity in partial epilepsy: a resting-state fMRI study.1932-620310.1371/journal.pone.0028196https://doaj.org/article/3de9ef3691eb4ddda255ba7e2ecb9e672011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22242146/?tool=EBIhttps://doaj.org/toc/1932-6203Examining the spontaneous activity to understand the neural mechanism of brain disorder is a focus in recent resting-state fMRI. In the current study, to investigate the alteration of brain functional connectivity in partial epilepsy in a systematical way, two levels of analyses (functional connectivity analysis within resting state networks (RSNs) and functional network connectivity (FNC) analysis) were carried out on resting-state fMRI data acquired from the 30 participants including 14 healthy controls(HC) and 16 partial epilepsy patients. According to the etiology, all patients are subdivided into temporal lobe epilepsy group (TLE, included 7 patients) and mixed partial epilepsy group (MPE, 9 patients). Using group independent component analysis, eight RSNs were identified, and selected to evaluate functional connectivity and FNC between groups. Compared with the controls, decreased functional connectivity within all RSNs was found in both TLE and MPE. However, dissociating patterns were observed within the 8 RSNs between two patient groups, i.e, compared with TLE, we found decreased functional connectivity in 5 RSNs increased functional connectivity in 1 RSN, and no difference in the other 2 RSNs in MPE. Furthermore, the hierarchical disconnections of FNC was found in two patient groups, in which the intra-system connections were preserved for all three subsystems while the lost connections were confined to intersystem connections in patients with partial epilepsy. These findings may suggest that decreased resting state functional connectivity and disconnection of FNC are two remarkable characteristics of partial epilepsy. The selective impairment of FNC implicated that it is unsuitable to understand the partial epilepsy only from global or local perspective. We presumed that studying epilepsy in the multi-perspective based on RSNs may be a valuable means to assess the functional changes corresponding to specific RSN and may contribute to the understanding of the neuro-pathophysiological mechanism of epilepsy.Cheng LuoChuan QiuZhiwei GuoJiajia FangQifu LiXu LeiYang XiaYongxiu LaiQiyong GongDong ZhouDezhong YaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e28196 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cheng Luo Chuan Qiu Zhiwei Guo Jiajia Fang Qifu Li Xu Lei Yang Xia Yongxiu Lai Qiyong Gong Dong Zhou Dezhong Yao Disrupted functional brain connectivity in partial epilepsy: a resting-state fMRI study.
description	Examining the spontaneous activity to understand the neural mechanism of brain disorder is a focus in recent resting-state fMRI. In the current study, to investigate the alteration of brain functional connectivity in partial epilepsy in a systematical way, two levels of analyses (functional connectivity analysis within resting state networks (RSNs) and functional network connectivity (FNC) analysis) were carried out on resting-state fMRI data acquired from the 30 participants including 14 healthy controls(HC) and 16 partial epilepsy patients. According to the etiology, all patients are subdivided into temporal lobe epilepsy group (TLE, included 7 patients) and mixed partial epilepsy group (MPE, 9 patients). Using group independent component analysis, eight RSNs were identified, and selected to evaluate functional connectivity and FNC between groups. Compared with the controls, decreased functional connectivity within all RSNs was found in both TLE and MPE. However, dissociating patterns were observed within the 8 RSNs between two patient groups, i.e, compared with TLE, we found decreased functional connectivity in 5 RSNs increased functional connectivity in 1 RSN, and no difference in the other 2 RSNs in MPE. Furthermore, the hierarchical disconnections of FNC was found in two patient groups, in which the intra-system connections were preserved for all three subsystems while the lost connections were confined to intersystem connections in patients with partial epilepsy. These findings may suggest that decreased resting state functional connectivity and disconnection of FNC are two remarkable characteristics of partial epilepsy. The selective impairment of FNC implicated that it is unsuitable to understand the partial epilepsy only from global or local perspective. We presumed that studying epilepsy in the multi-perspective based on RSNs may be a valuable means to assess the functional changes corresponding to specific RSN and may contribute to the understanding of the neuro-pathophysiological mechanism of epilepsy.
format	article
author	Cheng Luo Chuan Qiu Zhiwei Guo Jiajia Fang Qifu Li Xu Lei Yang Xia Yongxiu Lai Qiyong Gong Dong Zhou Dezhong Yao
author_facet	Cheng Luo Chuan Qiu Zhiwei Guo Jiajia Fang Qifu Li Xu Lei Yang Xia Yongxiu Lai Qiyong Gong Dong Zhou Dezhong Yao
author_sort	Cheng Luo
title	Disrupted functional brain connectivity in partial epilepsy: a resting-state fMRI study.
title_short	Disrupted functional brain connectivity in partial epilepsy: a resting-state fMRI study.
title_full	Disrupted functional brain connectivity in partial epilepsy: a resting-state fMRI study.
title_fullStr	Disrupted functional brain connectivity in partial epilepsy: a resting-state fMRI study.
title_full_unstemmed	Disrupted functional brain connectivity in partial epilepsy: a resting-state fMRI study.
title_sort	disrupted functional brain connectivity in partial epilepsy: a resting-state fmri study.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/3de9ef3691eb4ddda255ba7e2ecb9e67
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Disrupted functional brain connectivity in partial epilepsy: a resting-state fMRI study.

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