Antitumor Effects of Selenium

Functions of selenium are diverse as antioxidant, anti-inflammation, increased immunity, reduced cancer incidence, blocking tumor invasion and metastasis, and further clinical application as treatment with radiation and chemotherapy. These functions of selenium are mostly related to oxidation and re...

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Autores principales:	Seung Jo Kim, Min Chul Choi, Jong Min Park, An Sik Chung
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	selenium compounds ROS apoptosis metastasis treatment of advanced cancer patients Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/3deb5e03f9634b0f82b74818cfef5990
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id	oai:doaj.org-article:3deb5e03f9634b0f82b74818cfef5990
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spelling	oai:doaj.org-article:3deb5e03f9634b0f82b74818cfef59902021-11-11T17:16:28ZAntitumor Effects of Selenium10.3390/ijms2221118441422-00671661-6596https://doaj.org/article/3deb5e03f9634b0f82b74818cfef59902021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11844https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Functions of selenium are diverse as antioxidant, anti-inflammation, increased immunity, reduced cancer incidence, blocking tumor invasion and metastasis, and further clinical application as treatment with radiation and chemotherapy. These functions of selenium are mostly related to oxidation and reduction mechanisms of selenium metabolites. Hydrogen selenide from selenite, and methylselenol (MSeH) from Se-methylselenocyteine (MSeC) and methylseleninicacid (MSeA) are the most reactive metabolites produced reactive oxygen species (ROS); furthermore, these metabolites may involve in oxidizing sulfhydryl groups, including glutathione. Selenite also reacted with glutathione and produces hydrogen selenide via selenodiglutathione (SeDG), which induces cytotoxicity as cell apoptosis, ROS production, DNA damage, and adenosine-methionine methylation in the cellular nucleus. However, a more pronounced effect was shown in the subsequent treatment of sodium selenite with chemotherapy and radiation therapy. High doses of sodium selenite were effective to increase radiation therapy and chemotherapy, and further to reduce radiation side effects and drug resistance. In our study, advanced cancer patients can tolerate until 5000 μg of sodium selenite in combination with radiation and chemotherapy since the half-life of sodium selenite may be relatively short, and, further, selenium may accumulates more in cancer cells than that of normal cells, which may be toxic to the cancer cells. Further clinical studies of high amount sodium selenite are required to treat advanced cancer patients.Seung Jo KimMin Chul ChoiJong Min ParkAn Sik ChungMDPI AGarticleselenium compoundsROSapoptosismetastasistreatment of advanced cancer patientsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11844, p 11844 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	selenium compounds ROS apoptosis metastasis treatment of advanced cancer patients Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	selenium compounds ROS apoptosis metastasis treatment of advanced cancer patients Biology (General) QH301-705.5 Chemistry QD1-999 Seung Jo Kim Min Chul Choi Jong Min Park An Sik Chung Antitumor Effects of Selenium
description	Functions of selenium are diverse as antioxidant, anti-inflammation, increased immunity, reduced cancer incidence, blocking tumor invasion and metastasis, and further clinical application as treatment with radiation and chemotherapy. These functions of selenium are mostly related to oxidation and reduction mechanisms of selenium metabolites. Hydrogen selenide from selenite, and methylselenol (MSeH) from Se-methylselenocyteine (MSeC) and methylseleninicacid (MSeA) are the most reactive metabolites produced reactive oxygen species (ROS); furthermore, these metabolites may involve in oxidizing sulfhydryl groups, including glutathione. Selenite also reacted with glutathione and produces hydrogen selenide via selenodiglutathione (SeDG), which induces cytotoxicity as cell apoptosis, ROS production, DNA damage, and adenosine-methionine methylation in the cellular nucleus. However, a more pronounced effect was shown in the subsequent treatment of sodium selenite with chemotherapy and radiation therapy. High doses of sodium selenite were effective to increase radiation therapy and chemotherapy, and further to reduce radiation side effects and drug resistance. In our study, advanced cancer patients can tolerate until 5000 μg of sodium selenite in combination with radiation and chemotherapy since the half-life of sodium selenite may be relatively short, and, further, selenium may accumulates more in cancer cells than that of normal cells, which may be toxic to the cancer cells. Further clinical studies of high amount sodium selenite are required to treat advanced cancer patients.
format	article
author	Seung Jo Kim Min Chul Choi Jong Min Park An Sik Chung
author_facet	Seung Jo Kim Min Chul Choi Jong Min Park An Sik Chung
author_sort	Seung Jo Kim
title	Antitumor Effects of Selenium
title_short	Antitumor Effects of Selenium
title_full	Antitumor Effects of Selenium
title_fullStr	Antitumor Effects of Selenium
title_full_unstemmed	Antitumor Effects of Selenium
title_sort	antitumor effects of selenium
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3deb5e03f9634b0f82b74818cfef5990
work_keys_str_mv	AT seungjokim antitumoreffectsofselenium AT minchulchoi antitumoreffectsofselenium AT jongminpark antitumoreffectsofselenium AT ansikchung antitumoreffectsofselenium
_version_	1718432112015572992

Antitumor Effects of Selenium

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