Time-dependent haemoperfusion after acute paraquat poisoning

Abstract Early haemoperfusion (HP) therapy has been found to be very effective in acute paraquat (PQ) poisoning, but the effective rescue window is still uncertain. Demographic data and the type of therapies administered of 621 patients were included as confounding factors in this retrospective stud...

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Autores principales:	Hao-Ru Wang, Jian Pan, An-Dong Shang, Yuan-Qiang Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3defb2b5a7b549db9c66c286d57987ed
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spelling	oai:doaj.org-article:3defb2b5a7b549db9c66c286d57987ed2021-12-02T15:06:05ZTime-dependent haemoperfusion after acute paraquat poisoning10.1038/s41598-017-02527-02045-2322https://doaj.org/article/3defb2b5a7b549db9c66c286d57987ed2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02527-0https://doaj.org/toc/2045-2322Abstract Early haemoperfusion (HP) therapy has been found to be very effective in acute paraquat (PQ) poisoning, but the effective rescue window is still uncertain. Demographic data and the type of therapies administered of 621 patients were included as confounding factors in this retrospective study. After receiver operating characteristic curve analysis and intra-group/subgroup analysis, the initiation of glucocorticoid therapy within 3 hrs of exposure with a second treatment given <21 hrs after exposure, HP initiated within 4 hrs of exposure with a second treatment given <20 hrs after exposure, the appearance of pulmonary lesions ≤8 days after exposure and six other variables were used in a multiple analysis. The strength of positivity of the PQ urine test on admission, HP initiated within 4 hrs of exposure with a second treatment given <20 hrs after exposure, the appearance of pulmonary lesions ≤8 days after exposure, and stage III AKI on admission were independent factors of survival probability. HP therapy for acute PQ poisoning was the main therapeutic intervention investigated in this study. Outcomes were time dependent, and the crucial factor was the initiation of therapy within 4 hrs of PQ poisoning followed by a second treatment within 20 hrs.Hao-Ru WangJian PanAn-Dong ShangYuan-Qiang LuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hao-Ru Wang Jian Pan An-Dong Shang Yuan-Qiang Lu Time-dependent haemoperfusion after acute paraquat poisoning
description	Abstract Early haemoperfusion (HP) therapy has been found to be very effective in acute paraquat (PQ) poisoning, but the effective rescue window is still uncertain. Demographic data and the type of therapies administered of 621 patients were included as confounding factors in this retrospective study. After receiver operating characteristic curve analysis and intra-group/subgroup analysis, the initiation of glucocorticoid therapy within 3 hrs of exposure with a second treatment given <21 hrs after exposure, HP initiated within 4 hrs of exposure with a second treatment given <20 hrs after exposure, the appearance of pulmonary lesions ≤8 days after exposure and six other variables were used in a multiple analysis. The strength of positivity of the PQ urine test on admission, HP initiated within 4 hrs of exposure with a second treatment given <20 hrs after exposure, the appearance of pulmonary lesions ≤8 days after exposure, and stage III AKI on admission were independent factors of survival probability. HP therapy for acute PQ poisoning was the main therapeutic intervention investigated in this study. Outcomes were time dependent, and the crucial factor was the initiation of therapy within 4 hrs of PQ poisoning followed by a second treatment within 20 hrs.
format	article
author	Hao-Ru Wang Jian Pan An-Dong Shang Yuan-Qiang Lu
author_facet	Hao-Ru Wang Jian Pan An-Dong Shang Yuan-Qiang Lu
author_sort	Hao-Ru Wang
title	Time-dependent haemoperfusion after acute paraquat poisoning
title_short	Time-dependent haemoperfusion after acute paraquat poisoning
title_full	Time-dependent haemoperfusion after acute paraquat poisoning
title_fullStr	Time-dependent haemoperfusion after acute paraquat poisoning
title_full_unstemmed	Time-dependent haemoperfusion after acute paraquat poisoning
title_sort	time-dependent haemoperfusion after acute paraquat poisoning
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3defb2b5a7b549db9c66c286d57987ed
work_keys_str_mv	AT haoruwang timedependenthaemoperfusionafteracuteparaquatpoisoning AT jianpan timedependenthaemoperfusionafteracuteparaquatpoisoning AT andongshang timedependenthaemoperfusionafteracuteparaquatpoisoning AT yuanqianglu timedependenthaemoperfusionafteracuteparaquatpoisoning
_version_	1718388576669925376

Time-dependent haemoperfusion after acute paraquat poisoning

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