Comparison of Vaginal Cream of Coconut Oil and Clotrimazole on Candidal Infection of Vagina

BACKGROUND AND OBJECTIVE: Candidiasis is the second common vaginal infection, and commonly used drugs are azoles. Over-consumption of Azol is associated with resistance to drug and treatment failure. Studies conducted in vitro confirm the antifungal effects of coconut oil. The aim of this study was...

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Autores principales:	S Sheidaei, F Jafarnejad, O Rajabi, MJ Najafzadeh
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2019
Materias:	vaginal candidiasis coconut oil clotrimazole Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3df05c739f0a4d0bb25f0c122964b029
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spelling	oai:doaj.org-article:3df05c739f0a4d0bb25f0c122964b0292021-11-10T08:30:36ZComparison of Vaginal Cream of Coconut Oil and Clotrimazole on Candidal Infection of Vagina1561-41072251-7170https://doaj.org/article/3df05c739f0a4d0bb25f0c122964b0292019-12-01T00:00:00Zhttp://jbums.org/article-1-7988-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Candidiasis is the second common vaginal infection, and commonly used drugs are azoles. Over-consumption of Azol is associated with resistance to drug and treatment failure. Studies conducted in vitro confirm the antifungal effects of coconut oil. The aim of this study was to compare the effect of vaginal cream of coconut oil and clotrimazole on vaginal candidiasis infection. METHODS: This clinical trial study was performed on 71 women with Candida infection in two groups receiving vaginal cream of coconut oil: 35(78%) and clotrimazole (36%) (1%) who were treated for 7 nights (one applicator per night). One week after the completion of the treatment, patients were re-examined. Itching, burning, pain and secretion were compared in two groups. FINDINGS: After the mean intervention (itching in the coconut group was 0±0 and in the clotrimazole group was 19±0.46 (p=0.017), (burning in the coconut group was 0.08±0.20 and in the clotrimazole group was 57% (p=0.046), (secretion in the coconut group was 0.05±0.23 and in the clotrimazole group was 66.6 ± 0.98 (p=0.001) (pain during sex in the coconut group 23 0.05 and 0.30±0.62 in the clotrimazole group (p=0.031). However, the success of the treatment (negative culture) was not significant between the two groups (p<0.05). CONCLUSION: The present study showed that vaginal cream of coconut oil and clotriamzole both improve vaginal candidiasis infection. Therefore, vaginal cream of coconut oil can be used as an alternative treatment for vaginal candidiasis.S SheidaeiF JafarnejadO RajabiMJ NajafzadehBabol University of Medical Sciencesarticlevaginal candidiasiscoconut oilclotrimazoleMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 21, Iss 1, Pp 93-98 (2019)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	vaginal candidiasis coconut oil clotrimazole Medicine R Medicine (General) R5-920
spellingShingle	vaginal candidiasis coconut oil clotrimazole Medicine R Medicine (General) R5-920 S Sheidaei F Jafarnejad O Rajabi MJ Najafzadeh Comparison of Vaginal Cream of Coconut Oil and Clotrimazole on Candidal Infection of Vagina
description	BACKGROUND AND OBJECTIVE: Candidiasis is the second common vaginal infection, and commonly used drugs are azoles. Over-consumption of Azol is associated with resistance to drug and treatment failure. Studies conducted in vitro confirm the antifungal effects of coconut oil. The aim of this study was to compare the effect of vaginal cream of coconut oil and clotrimazole on vaginal candidiasis infection. METHODS: This clinical trial study was performed on 71 women with Candida infection in two groups receiving vaginal cream of coconut oil: 35(78%) and clotrimazole (36%) (1%) who were treated for 7 nights (one applicator per night). One week after the completion of the treatment, patients were re-examined. Itching, burning, pain and secretion were compared in two groups. FINDINGS: After the mean intervention (itching in the coconut group was 0±0 and in the clotrimazole group was 19±0.46 (p=0.017), (burning in the coconut group was 0.08±0.20 and in the clotrimazole group was 57% (p=0.046), (secretion in the coconut group was 0.05±0.23 and in the clotrimazole group was 66.6 ± 0.98 (p=0.001) (pain during sex in the coconut group 23 0.05 and 0.30±0.62 in the clotrimazole group (p=0.031). However, the success of the treatment (negative culture) was not significant between the two groups (p<0.05). CONCLUSION: The present study showed that vaginal cream of coconut oil and clotriamzole both improve vaginal candidiasis infection. Therefore, vaginal cream of coconut oil can be used as an alternative treatment for vaginal candidiasis.
format	article
author	S Sheidaei F Jafarnejad O Rajabi MJ Najafzadeh
author_facet	S Sheidaei F Jafarnejad O Rajabi MJ Najafzadeh
author_sort	S Sheidaei
title	Comparison of Vaginal Cream of Coconut Oil and Clotrimazole on Candidal Infection of Vagina
title_short	Comparison of Vaginal Cream of Coconut Oil and Clotrimazole on Candidal Infection of Vagina
title_full	Comparison of Vaginal Cream of Coconut Oil and Clotrimazole on Candidal Infection of Vagina
title_fullStr	Comparison of Vaginal Cream of Coconut Oil and Clotrimazole on Candidal Infection of Vagina
title_full_unstemmed	Comparison of Vaginal Cream of Coconut Oil and Clotrimazole on Candidal Infection of Vagina
title_sort	comparison of vaginal cream of coconut oil and clotrimazole on candidal infection of vagina
publisher	Babol University of Medical Sciences
publishDate	2019
url	https://doaj.org/article/3df05c739f0a4d0bb25f0c122964b029
work_keys_str_mv	AT ssheidaei comparisonofvaginalcreamofcoconutoilandclotrimazoleoncandidalinfectionofvagina AT fjafarnejad comparisonofvaginalcreamofcoconutoilandclotrimazoleoncandidalinfectionofvagina AT orajabi comparisonofvaginalcreamofcoconutoilandclotrimazoleoncandidalinfectionofvagina AT mjnajafzadeh comparisonofvaginalcreamofcoconutoilandclotrimazoleoncandidalinfectionofvagina
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Comparison of Vaginal Cream of Coconut Oil and Clotrimazole on Candidal Infection of Vagina

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