Associations of GWAS-Supported Non-MHC Genes with Autoimmune Thyroiditis in Patients with Type 1 Diabetes

Jialin Liang,1 Ganxiong Liang,1 Zhonghua Liu,2 Huan Cai2 1Department of Endocrinology and Metabolism, Zhongshan People’s Hospital, Zhongshan, 528403, Guangdong, People’s Republic of China; 2Department of Rehabilitation, Zhongshan People’s Hospital, Zhongshan, 528403, Guangdong, People’s Republic of...

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Autores principales:	Liang J, Liang G, Liu Z, Cai H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	autoimmune thyroid diseases type 1 diabetes single-nucleotide polymorphism qrfpr gene Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/3df65c1903c1427bb0ce2dc6bc3c2c60
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spelling	oai:doaj.org-article:3df65c1903c1427bb0ce2dc6bc3c2c602021-12-02T18:18:38ZAssociations of GWAS-Supported Non-MHC Genes with Autoimmune Thyroiditis in Patients with Type 1 Diabetes1178-7007https://doaj.org/article/3df65c1903c1427bb0ce2dc6bc3c2c602021-07-01T00:00:00Zhttps://www.dovepress.com/associations-of-gwas-supported-non-mhc-genes-with-autoimmune-thyroidit-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Jialin Liang,1 Ganxiong Liang,1 Zhonghua Liu,2 Huan Cai2 1Department of Endocrinology and Metabolism, Zhongshan People’s Hospital, Zhongshan, 528403, Guangdong, People’s Republic of China; 2Department of Rehabilitation, Zhongshan People’s Hospital, Zhongshan, 528403, Guangdong, People’s Republic of ChinaCorrespondence: Ganxiong LiangDepartment of Endocrinology and Metabolism, Zhongshan People’s Hospital, 2 East Sunwen Road, Zhongshan, 528403, Guangdong, People’s Republic of ChinaTel +86-13392926029Email ganxiong_liang@126.comHuan CaiDepartment of Rehabilitation, Zhongshan People’s Hospital, 2 East Sunwen Road, Zhongshan, 528403, Guangdong, People’s Republic of ChinaTel +86-18718750210Email ch.neurol@gmail.comPurpose: A genome-wide association study (GWAS) in Caucasian population identified five non-MHC genes (PHTF1, PTPN22, MAGI3, BCL2L15, and QRFPR) associated with risk of the co-occurrence of autoimmune thyroid diseases (AITD) and type 1 diabetes (T1D). The aim of this study is to replicate these associations with AITD in patients with T1D in Chinese Han population.Patients and Methods: A case–control study was designed. Five single-nucleotide polymorphisms (SNPs) PHTF1 rs1111695, PTPN22 rs1217407, MAGI3 rs2153977, BCL2L15 rs2358994, and QRFPR rs7679475 were genotyped in 489 patients with T1D. Associations between genotypes and AITD risk were analyzed with logistic regression model.Results: AITD occurred in 159 (32.5%) patients. When adjusting multiple factors by logistic regression, QRFPR rs7679475 was significantly associated with an increased risk of AITD in T1D patients in codominant model (G/G vs A/A, OR 2.93; 95% CI 1.44– 5.96; P = 0.003), dominant model (G/A-G/G vs A/A, OR 1.81; 95% CI 1.17– 2.79; P = 0.007) and recessive model (G/G vs A/A-G/A, OR 2.28; 95% CI 1.17– 4.43; P = 0.015). Furthermore, we found a significant interaction between rs7679475 and female (P interaction = 0.005). In silico analysis indicated that rs7679475 is located in histone modification marked region and can change the binding of regulatory motifs.Conclusion: Our results suggested that QRFPR rs7679475 may influence the risk of AITD in patients with T1D in Chinese Han population, and this effect may be modulated by sex.Keywords: autoimmune thyroid diseases, type 1 diabetes, single-nucleotide polymorphism, QRFPR geneLiang JLiang GLiu ZCai HDove Medical Pressarticleautoimmune thyroid diseasestype 1 diabetessingle-nucleotide polymorphismqrfpr geneSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 3017-3026 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autoimmune thyroid diseases type 1 diabetes single-nucleotide polymorphism qrfpr gene Specialties of internal medicine RC581-951
spellingShingle	autoimmune thyroid diseases type 1 diabetes single-nucleotide polymorphism qrfpr gene Specialties of internal medicine RC581-951 Liang J Liang G Liu Z Cai H Associations of GWAS-Supported Non-MHC Genes with Autoimmune Thyroiditis in Patients with Type 1 Diabetes
description	Jialin Liang,1 Ganxiong Liang,1 Zhonghua Liu,2 Huan Cai2 1Department of Endocrinology and Metabolism, Zhongshan People’s Hospital, Zhongshan, 528403, Guangdong, People’s Republic of China; 2Department of Rehabilitation, Zhongshan People’s Hospital, Zhongshan, 528403, Guangdong, People’s Republic of ChinaCorrespondence: Ganxiong LiangDepartment of Endocrinology and Metabolism, Zhongshan People’s Hospital, 2 East Sunwen Road, Zhongshan, 528403, Guangdong, People’s Republic of ChinaTel +86-13392926029Email ganxiong_liang@126.comHuan CaiDepartment of Rehabilitation, Zhongshan People’s Hospital, 2 East Sunwen Road, Zhongshan, 528403, Guangdong, People’s Republic of ChinaTel +86-18718750210Email ch.neurol@gmail.comPurpose: A genome-wide association study (GWAS) in Caucasian population identified five non-MHC genes (PHTF1, PTPN22, MAGI3, BCL2L15, and QRFPR) associated with risk of the co-occurrence of autoimmune thyroid diseases (AITD) and type 1 diabetes (T1D). The aim of this study is to replicate these associations with AITD in patients with T1D in Chinese Han population.Patients and Methods: A case–control study was designed. Five single-nucleotide polymorphisms (SNPs) PHTF1 rs1111695, PTPN22 rs1217407, MAGI3 rs2153977, BCL2L15 rs2358994, and QRFPR rs7679475 were genotyped in 489 patients with T1D. Associations between genotypes and AITD risk were analyzed with logistic regression model.Results: AITD occurred in 159 (32.5%) patients. When adjusting multiple factors by logistic regression, QRFPR rs7679475 was significantly associated with an increased risk of AITD in T1D patients in codominant model (G/G vs A/A, OR 2.93; 95% CI 1.44– 5.96; P = 0.003), dominant model (G/A-G/G vs A/A, OR 1.81; 95% CI 1.17– 2.79; P = 0.007) and recessive model (G/G vs A/A-G/A, OR 2.28; 95% CI 1.17– 4.43; P = 0.015). Furthermore, we found a significant interaction between rs7679475 and female (P interaction = 0.005). In silico analysis indicated that rs7679475 is located in histone modification marked region and can change the binding of regulatory motifs.Conclusion: Our results suggested that QRFPR rs7679475 may influence the risk of AITD in patients with T1D in Chinese Han population, and this effect may be modulated by sex.Keywords: autoimmune thyroid diseases, type 1 diabetes, single-nucleotide polymorphism, QRFPR gene
format	article
author	Liang J Liang G Liu Z Cai H
author_facet	Liang J Liang G Liu Z Cai H
author_sort	Liang J
title	Associations of GWAS-Supported Non-MHC Genes with Autoimmune Thyroiditis in Patients with Type 1 Diabetes
title_short	Associations of GWAS-Supported Non-MHC Genes with Autoimmune Thyroiditis in Patients with Type 1 Diabetes
title_full	Associations of GWAS-Supported Non-MHC Genes with Autoimmune Thyroiditis in Patients with Type 1 Diabetes
title_fullStr	Associations of GWAS-Supported Non-MHC Genes with Autoimmune Thyroiditis in Patients with Type 1 Diabetes
title_full_unstemmed	Associations of GWAS-Supported Non-MHC Genes with Autoimmune Thyroiditis in Patients with Type 1 Diabetes
title_sort	associations of gwas-supported non-mhc genes with autoimmune thyroiditis in patients with type 1 diabetes
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/3df65c1903c1427bb0ce2dc6bc3c2c60
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Associations of GWAS-Supported Non-MHC Genes with Autoimmune Thyroiditis in Patients with Type 1 Diabetes

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