UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells
STIM proteins sense Ca2+ depletion in the ER and activate store-operated Ca2+ entry in response, a process associated with dendritic cell (DC) functions. Here, the authors show that optimal antigen cross-presentation in DCs requires the association of the chaperone molecule UNC93B1 with STIM1.
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Nature Portfolio
2017
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oai:doaj.org-article:3df7bd0b89fc4e89876f33ce40769f732021-12-02T14:42:44ZUNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells10.1038/s41467-017-01601-52041-1723https://doaj.org/article/3df7bd0b89fc4e89876f33ce40769f732017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01601-5https://doaj.org/toc/2041-1723STIM proteins sense Ca2+ depletion in the ER and activate store-operated Ca2+ entry in response, a process associated with dendritic cell (DC) functions. Here, the authors show that optimal antigen cross-presentation in DCs requires the association of the chaperone molecule UNC93B1 with STIM1.Sophia MaschalidiPaula Nunes-HaslerClarissa R NascimentoIgnacio SallentValérie LannoyMeriem Garfa-TraoreNicolas CagnardFernando E. SepulvedaPablo VargasAna-Maria Lennon-DuménilPeter van EndertThierry CapiodNicolas DemaurexGuillaume Darrasse-JèzeBénédicte ManouryNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Sophia Maschalidi Paula Nunes-Hasler Clarissa R Nascimento Ignacio Sallent Valérie Lannoy Meriem Garfa-Traore Nicolas Cagnard Fernando E. Sepulveda Pablo Vargas Ana-Maria Lennon-Duménil Peter van Endert Thierry Capiod Nicolas Demaurex Guillaume Darrasse-Jèze Bénédicte Manoury UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells |
| description |
STIM proteins sense Ca2+ depletion in the ER and activate store-operated Ca2+ entry in response, a process associated with dendritic cell (DC) functions. Here, the authors show that optimal antigen cross-presentation in DCs requires the association of the chaperone molecule UNC93B1 with STIM1. |
| format |
article |
| author |
Sophia Maschalidi Paula Nunes-Hasler Clarissa R Nascimento Ignacio Sallent Valérie Lannoy Meriem Garfa-Traore Nicolas Cagnard Fernando E. Sepulveda Pablo Vargas Ana-Maria Lennon-Duménil Peter van Endert Thierry Capiod Nicolas Demaurex Guillaume Darrasse-Jèze Bénédicte Manoury |
| author_facet |
Sophia Maschalidi Paula Nunes-Hasler Clarissa R Nascimento Ignacio Sallent Valérie Lannoy Meriem Garfa-Traore Nicolas Cagnard Fernando E. Sepulveda Pablo Vargas Ana-Maria Lennon-Duménil Peter van Endert Thierry Capiod Nicolas Demaurex Guillaume Darrasse-Jèze Bénédicte Manoury |
| author_sort |
Sophia Maschalidi |
| title |
UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells |
| title_short |
UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells |
| title_full |
UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells |
| title_fullStr |
UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells |
| title_full_unstemmed |
UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells |
| title_sort |
unc93b1 interacts with the calcium sensor stim1 for efficient antigen cross-presentation in dendritic cells |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/3df7bd0b89fc4e89876f33ce40769f73 |
| work_keys_str_mv |
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| _version_ |
1718389562034618368 |