Epigenetic modification of gene expression in honey bees by heterospecific gland secretions.

<h4>Background</h4>In the honey bee (Apis mellifera), queen and workers have different behavior and reproductive capacity despite possessing the same genome. The primary substance that leads to this differentiation is royal jelly (RJ), which contains a range of proteins, amino acids, vit...

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Autores principales:	Yuan Yuan Shi, Xiao Bo Wu, Zachary Y Huang, Zi Long Wang, Wei Yu Yan, Zhi Jiang Zeng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3dfd2f3705c84f1c806c1723f8c674d3
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spelling	oai:doaj.org-article:3dfd2f3705c84f1c806c1723f8c674d32021-11-18T07:08:04ZEpigenetic modification of gene expression in honey bees by heterospecific gland secretions.1932-620310.1371/journal.pone.0043727https://doaj.org/article/3dfd2f3705c84f1c806c1723f8c674d32012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22928024/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>In the honey bee (Apis mellifera), queen and workers have different behavior and reproductive capacity despite possessing the same genome. The primary substance that leads to this differentiation is royal jelly (RJ), which contains a range of proteins, amino acids, vitamins and nucleic acids. MicroRNA (miRNA) has been found to play an important role in regulating the expression of protein-coding genes and cell biology. In this study, we characterized the miRNAs in RJ from two honey bee sister species and determined their possible effect on transcriptome in one species.<h4>Methodology/principal findings</h4>We sequenced the miRNAs in RJ either from A. mellifera (RJM) or A. cerana (RJC). We then determined the global transcriptomes of adult A. mellifera developed from larvae fed either with RJM (mRJM) or RJC (mRJC). Finally we analyzed the target genes of those miRNA that are species specific or differentially expressed in the two honey bee species. We show that there were differences in miRNA between RJM and RJC, and that transcriptomes of adult A. mellifera were affected by the two types of RJ. A high proportion (23.3%) of the affected genes were target genes of differential miRNAs.<h4>Conclusion</h4>We show for the first time that there are differences in miRNAs in RJ between A. mellifera and A. cerana. Further, the differences in transcriptomes of bees reared from these two RJs might be related to miRNA differences of the two species. This study provides the first evidence that heterospecific royal jelly can modify gene expression in honey bees through an epigenetic mechanism.Yuan Yuan ShiXiao Bo WuZachary Y HuangZi Long WangWei Yu YanZhi Jiang ZengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e43727 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuan Yuan Shi Xiao Bo Wu Zachary Y Huang Zi Long Wang Wei Yu Yan Zhi Jiang Zeng Epigenetic modification of gene expression in honey bees by heterospecific gland secretions.
description	<h4>Background</h4>In the honey bee (Apis mellifera), queen and workers have different behavior and reproductive capacity despite possessing the same genome. The primary substance that leads to this differentiation is royal jelly (RJ), which contains a range of proteins, amino acids, vitamins and nucleic acids. MicroRNA (miRNA) has been found to play an important role in regulating the expression of protein-coding genes and cell biology. In this study, we characterized the miRNAs in RJ from two honey bee sister species and determined their possible effect on transcriptome in one species.<h4>Methodology/principal findings</h4>We sequenced the miRNAs in RJ either from A. mellifera (RJM) or A. cerana (RJC). We then determined the global transcriptomes of adult A. mellifera developed from larvae fed either with RJM (mRJM) or RJC (mRJC). Finally we analyzed the target genes of those miRNA that are species specific or differentially expressed in the two honey bee species. We show that there were differences in miRNA between RJM and RJC, and that transcriptomes of adult A. mellifera were affected by the two types of RJ. A high proportion (23.3%) of the affected genes were target genes of differential miRNAs.<h4>Conclusion</h4>We show for the first time that there are differences in miRNAs in RJ between A. mellifera and A. cerana. Further, the differences in transcriptomes of bees reared from these two RJs might be related to miRNA differences of the two species. This study provides the first evidence that heterospecific royal jelly can modify gene expression in honey bees through an epigenetic mechanism.
format	article
author	Yuan Yuan Shi Xiao Bo Wu Zachary Y Huang Zi Long Wang Wei Yu Yan Zhi Jiang Zeng
author_facet	Yuan Yuan Shi Xiao Bo Wu Zachary Y Huang Zi Long Wang Wei Yu Yan Zhi Jiang Zeng
author_sort	Yuan Yuan Shi
title	Epigenetic modification of gene expression in honey bees by heterospecific gland secretions.
title_short	Epigenetic modification of gene expression in honey bees by heterospecific gland secretions.
title_full	Epigenetic modification of gene expression in honey bees by heterospecific gland secretions.
title_fullStr	Epigenetic modification of gene expression in honey bees by heterospecific gland secretions.
title_full_unstemmed	Epigenetic modification of gene expression in honey bees by heterospecific gland secretions.
title_sort	epigenetic modification of gene expression in honey bees by heterospecific gland secretions.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/3dfd2f3705c84f1c806c1723f8c674d3
work_keys_str_mv	AT yuanyuanshi epigeneticmodificationofgeneexpressioninhoneybeesbyheterospecificglandsecretions AT xiaobowu epigeneticmodificationofgeneexpressioninhoneybeesbyheterospecificglandsecretions AT zacharyyhuang epigeneticmodificationofgeneexpressioninhoneybeesbyheterospecificglandsecretions AT zilongwang epigeneticmodificationofgeneexpressioninhoneybeesbyheterospecificglandsecretions AT weiyuyan epigeneticmodificationofgeneexpressioninhoneybeesbyheterospecificglandsecretions AT zhijiangzeng epigeneticmodificationofgeneexpressioninhoneybeesbyheterospecificglandsecretions
_version_	1718423910779715584

Epigenetic modification of gene expression in honey bees by heterospecific gland secretions.

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