The accuracy and precision of insulin administration using human and veterinary pen‐injectors and syringes for administration of insulin

Abstract Background Many diabetic dogs and cats require small doses of insulin that must be administered accurately. Objectives To compare the accuracy and precision of insulin syringes and pen‐injectors. Animals None. Methods To determine how accurately and precisely insulin doses are delivered, 0....

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Autores principales:	Eleonora Malerba, Federico Fracassi, Francesca Del Baldo, Stefania Golinelli, Martina Ceccherini, Andrea Barbarossa
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	canine cartridge device diabetes mellitus feline insulin Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/3dfdd1a9d405457ea1471fff08597a7f
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spelling	oai:doaj.org-article:3dfdd1a9d405457ea1471fff08597a7f2021-11-30T17:01:03ZThe accuracy and precision of insulin administration using human and veterinary pen‐injectors and syringes for administration of insulin1939-16760891-664010.1111/jvim.16126https://doaj.org/article/3dfdd1a9d405457ea1471fff08597a7f2021-05-01T00:00:00Zhttps://doi.org/10.1111/jvim.16126https://doaj.org/toc/0891-6640https://doaj.org/toc/1939-1676Abstract Background Many diabetic dogs and cats require small doses of insulin that must be administered accurately. Objectives To compare the accuracy and precision of insulin syringes and pen‐injectors. Animals None. Methods To determine how accurately and precisely insulin doses are delivered, 0.5, 1, 2, 4, 8, and 16 U doses were dispensed 25 times from 5 SoloSTARs, 5 FlexPens, 5 KwikPens, 5 JuniorSTARs, 5 VetPens 0.5‐8 U, 5 VetPens 1‐16 U, and by 5 veterinarians using 30 U/0.3 mL and 40 U/mL insulin syringes. Each dose was weighed, using a precision balance, and the intended and delivered doses were compared. Results All pen‐injectors delivered less insulin than the intended dose, underdosage being inversely proportional to insulin dose. The differences between the intended and the delivered dose were not significant using JuniorSTAR and VetPen 0.5‐8 U at insulin doses of 0.5, 1, 2, and 4 U, using the 30 U/0.3 mL insulin syringe at the 4 U dose and using the 40 U/mL insulin syringe at the 4, 8, and 16 U doses. With all the devices, precision increased with increasing doses of insulin. The coefficient of variation was <8% for all 6 pen‐injectors. Conversely, using 30 U/0.3 mL and 40 U/mL syringes at an insulin dosage of 0.5 U the coefficients of variation were 12.08% and 9.39%, respectively. Conclusions and Clinical Importance JuniorSTAR and VetPen 0.5‐8 U were more accurate than the other devices when delivering ≤2 U doses, while the delivery of 8 and 16 U doses was more accurate using 40 U/mL syringes.Eleonora MalerbaFederico FracassiFrancesca Del BaldoStefania GolinelliMartina CeccheriniAndrea BarbarossaWileyarticlecaninecartridgedevicediabetes mellitusfelineinsulinVeterinary medicineSF600-1100ENJournal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1255-1264 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	canine cartridge device diabetes mellitus feline insulin Veterinary medicine SF600-1100
spellingShingle	canine cartridge device diabetes mellitus feline insulin Veterinary medicine SF600-1100 Eleonora Malerba Federico Fracassi Francesca Del Baldo Stefania Golinelli Martina Ceccherini Andrea Barbarossa The accuracy and precision of insulin administration using human and veterinary pen‐injectors and syringes for administration of insulin
description	Abstract Background Many diabetic dogs and cats require small doses of insulin that must be administered accurately. Objectives To compare the accuracy and precision of insulin syringes and pen‐injectors. Animals None. Methods To determine how accurately and precisely insulin doses are delivered, 0.5, 1, 2, 4, 8, and 16 U doses were dispensed 25 times from 5 SoloSTARs, 5 FlexPens, 5 KwikPens, 5 JuniorSTARs, 5 VetPens 0.5‐8 U, 5 VetPens 1‐16 U, and by 5 veterinarians using 30 U/0.3 mL and 40 U/mL insulin syringes. Each dose was weighed, using a precision balance, and the intended and delivered doses were compared. Results All pen‐injectors delivered less insulin than the intended dose, underdosage being inversely proportional to insulin dose. The differences between the intended and the delivered dose were not significant using JuniorSTAR and VetPen 0.5‐8 U at insulin doses of 0.5, 1, 2, and 4 U, using the 30 U/0.3 mL insulin syringe at the 4 U dose and using the 40 U/mL insulin syringe at the 4, 8, and 16 U doses. With all the devices, precision increased with increasing doses of insulin. The coefficient of variation was <8% for all 6 pen‐injectors. Conversely, using 30 U/0.3 mL and 40 U/mL syringes at an insulin dosage of 0.5 U the coefficients of variation were 12.08% and 9.39%, respectively. Conclusions and Clinical Importance JuniorSTAR and VetPen 0.5‐8 U were more accurate than the other devices when delivering ≤2 U doses, while the delivery of 8 and 16 U doses was more accurate using 40 U/mL syringes.
format	article
author	Eleonora Malerba Federico Fracassi Francesca Del Baldo Stefania Golinelli Martina Ceccherini Andrea Barbarossa
author_facet	Eleonora Malerba Federico Fracassi Francesca Del Baldo Stefania Golinelli Martina Ceccherini Andrea Barbarossa
author_sort	Eleonora Malerba
title	The accuracy and precision of insulin administration using human and veterinary pen‐injectors and syringes for administration of insulin
title_short	The accuracy and precision of insulin administration using human and veterinary pen‐injectors and syringes for administration of insulin
title_full	The accuracy and precision of insulin administration using human and veterinary pen‐injectors and syringes for administration of insulin
title_fullStr	The accuracy and precision of insulin administration using human and veterinary pen‐injectors and syringes for administration of insulin
title_full_unstemmed	The accuracy and precision of insulin administration using human and veterinary pen‐injectors and syringes for administration of insulin
title_sort	accuracy and precision of insulin administration using human and veterinary pen‐injectors and syringes for administration of insulin
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/3dfdd1a9d405457ea1471fff08597a7f
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The accuracy and precision of insulin administration using human and veterinary pen‐injectors and syringes for administration of insulin

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