An association between fibroblast growth factor 21 and cognitive impairment in iron-overload thalassemia

Abstract Although an increased fibroblast growth factor 21 (FGF21) level was related to mild cognitive impairment (MCI) in metabolic syndrome patients, any association regarding FGF21 and MCI in thalassemia patients as well as mechanistic insight are questionable. Therefore, the objectives of this s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wasan Theerajangkhaphichai, Jirapas Sripetchwandee, Sirawit Sriwichaiin, Saovaros Svasti, Nipon Chattipakorn, Adisak Tantiworawit, Siriporn C. Chattipakorn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3dfff1659f4844ba8ae09c9265f57103
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3dfff1659f4844ba8ae09c9265f57103
record_format	dspace
spelling	oai:doaj.org-article:3dfff1659f4844ba8ae09c9265f571032021-12-02T15:51:13ZAn association between fibroblast growth factor 21 and cognitive impairment in iron-overload thalassemia10.1038/s41598-021-87597-x2045-2322https://doaj.org/article/3dfff1659f4844ba8ae09c9265f571032021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87597-xhttps://doaj.org/toc/2045-2322Abstract Although an increased fibroblast growth factor 21 (FGF21) level was related to mild cognitive impairment (MCI) in metabolic syndrome patients, any association regarding FGF21 and MCI in thalassemia patients as well as mechanistic insight are questionable. Therefore, the objectives of this study were: (1) to investigate the prevalence and associative risk factors of MCI in thalassemia patients, (2) to evaluate the association between levels of FGF21 and MCI in thalassemia patients, and (3) to investigate brain FGF21 signaling in iron-overload thalassemia. Thalassemia patients were enrolled onto the study (n = 131). Montreal cognitive assessment (MoCA) was used to determine cognitive performance. Plasma FGF21 level was determined in all patients. Iron-overload β-thalassemic (HT) mice were used to investigate brain FGF21 level and signaling, the expression of synaptic proteins, and Alzheimer’s like pathology. We found that 70% of thalassemia patients developed MCI. FGF21 level was positively correlated with the MCI. Interestingly, brain FGF21 resistance, as indicated by increased brain FGF21 levels with impaired FGF21 signaling, was found in iron-overload HT mice. The reduced synaptic protein expression and increased Alzheimer’s like pathology were also observed. These suggest that FGF21 may play a role in MCI in thalassemia patients.Wasan TheerajangkhaphichaiJirapas SripetchwandeeSirawit SriwichaiinSaovaros SvastiNipon ChattipakornAdisak TantiworawitSiriporn C. ChattipakornNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wasan Theerajangkhaphichai Jirapas Sripetchwandee Sirawit Sriwichaiin Saovaros Svasti Nipon Chattipakorn Adisak Tantiworawit Siriporn C. Chattipakorn An association between fibroblast growth factor 21 and cognitive impairment in iron-overload thalassemia
description	Abstract Although an increased fibroblast growth factor 21 (FGF21) level was related to mild cognitive impairment (MCI) in metabolic syndrome patients, any association regarding FGF21 and MCI in thalassemia patients as well as mechanistic insight are questionable. Therefore, the objectives of this study were: (1) to investigate the prevalence and associative risk factors of MCI in thalassemia patients, (2) to evaluate the association between levels of FGF21 and MCI in thalassemia patients, and (3) to investigate brain FGF21 signaling in iron-overload thalassemia. Thalassemia patients were enrolled onto the study (n = 131). Montreal cognitive assessment (MoCA) was used to determine cognitive performance. Plasma FGF21 level was determined in all patients. Iron-overload β-thalassemic (HT) mice were used to investigate brain FGF21 level and signaling, the expression of synaptic proteins, and Alzheimer’s like pathology. We found that 70% of thalassemia patients developed MCI. FGF21 level was positively correlated with the MCI. Interestingly, brain FGF21 resistance, as indicated by increased brain FGF21 levels with impaired FGF21 signaling, was found in iron-overload HT mice. The reduced synaptic protein expression and increased Alzheimer’s like pathology were also observed. These suggest that FGF21 may play a role in MCI in thalassemia patients.
format	article
author	Wasan Theerajangkhaphichai Jirapas Sripetchwandee Sirawit Sriwichaiin Saovaros Svasti Nipon Chattipakorn Adisak Tantiworawit Siriporn C. Chattipakorn
author_facet	Wasan Theerajangkhaphichai Jirapas Sripetchwandee Sirawit Sriwichaiin Saovaros Svasti Nipon Chattipakorn Adisak Tantiworawit Siriporn C. Chattipakorn
author_sort	Wasan Theerajangkhaphichai
title	An association between fibroblast growth factor 21 and cognitive impairment in iron-overload thalassemia
title_short	An association between fibroblast growth factor 21 and cognitive impairment in iron-overload thalassemia
title_full	An association between fibroblast growth factor 21 and cognitive impairment in iron-overload thalassemia
title_fullStr	An association between fibroblast growth factor 21 and cognitive impairment in iron-overload thalassemia
title_full_unstemmed	An association between fibroblast growth factor 21 and cognitive impairment in iron-overload thalassemia
title_sort	association between fibroblast growth factor 21 and cognitive impairment in iron-overload thalassemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3dfff1659f4844ba8ae09c9265f57103
work_keys_str_mv	AT wasantheerajangkhaphichai anassociationbetweenfibroblastgrowthfactor21andcognitiveimpairmentinironoverloadthalassemia AT jirapassripetchwandee anassociationbetweenfibroblastgrowthfactor21andcognitiveimpairmentinironoverloadthalassemia AT sirawitsriwichaiin anassociationbetweenfibroblastgrowthfactor21andcognitiveimpairmentinironoverloadthalassemia AT saovarossvasti anassociationbetweenfibroblastgrowthfactor21andcognitiveimpairmentinironoverloadthalassemia AT niponchattipakorn anassociationbetweenfibroblastgrowthfactor21andcognitiveimpairmentinironoverloadthalassemia AT adisaktantiworawit anassociationbetweenfibroblastgrowthfactor21andcognitiveimpairmentinironoverloadthalassemia AT siriporncchattipakorn anassociationbetweenfibroblastgrowthfactor21andcognitiveimpairmentinironoverloadthalassemia AT wasantheerajangkhaphichai associationbetweenfibroblastgrowthfactor21andcognitiveimpairmentinironoverloadthalassemia AT jirapassripetchwandee associationbetweenfibroblastgrowthfactor21andcognitiveimpairmentinironoverloadthalassemia AT sirawitsriwichaiin associationbetweenfibroblastgrowthfactor21andcognitiveimpairmentinironoverloadthalassemia AT saovarossvasti associationbetweenfibroblastgrowthfactor21andcognitiveimpairmentinironoverloadthalassemia AT niponchattipakorn associationbetweenfibroblastgrowthfactor21andcognitiveimpairmentinironoverloadthalassemia AT adisaktantiworawit associationbetweenfibroblastgrowthfactor21andcognitiveimpairmentinironoverloadthalassemia AT siriporncchattipakorn associationbetweenfibroblastgrowthfactor21andcognitiveimpairmentinironoverloadthalassemia
_version_	1718385628082601984

An association between fibroblast growth factor 21 and cognitive impairment in iron-overload thalassemia

Ejemplares similares