Lipid Metabolism Disorders in the Comorbid Course of Nonalcoholic Fatty Liver Disease and Chronic Obstructive Pulmonary Disease

Non-alcoholic fatty liver disease (NAFLD) is currently among the most common liver diseases. Unfavorable data on the epidemiology of metabolic syndrome and obesity have increased the attention of clinicians and researchers to the problem of NAFLD. The research results allow us to emphasize the syste...

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Autores principales:	Stanislav Kotlyarov, Aleksei Bulgakov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	non-alcoholic fatty liver disease lipid metabolism metabolism chronic obstructive pulmonary disease Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3e0208c3b72f43ba94f5cd4e667235cd
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spelling	oai:doaj.org-article:3e0208c3b72f43ba94f5cd4e667235cd2021-11-25T17:09:58ZLipid Metabolism Disorders in the Comorbid Course of Nonalcoholic Fatty Liver Disease and Chronic Obstructive Pulmonary Disease10.3390/cells101129782073-4409https://doaj.org/article/3e0208c3b72f43ba94f5cd4e667235cd2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2978https://doaj.org/toc/2073-4409Non-alcoholic fatty liver disease (NAFLD) is currently among the most common liver diseases. Unfavorable data on the epidemiology of metabolic syndrome and obesity have increased the attention of clinicians and researchers to the problem of NAFLD. The research results allow us to emphasize the systemicity and multifactoriality of the pathogenesis of liver parenchyma lesion. At the same time, many aspects of its classification, etiology, and pathogenesis remain controversial. Local and systemic metabolic disorders are also a part of the pathogenesis of chronic obstructive pulmonary disease and can influence its course. The present article analyzes the metabolic pathways mediating the links of impaired lipid metabolism in NAFLD and chronic obstructive pulmonary disease (COPD). Free fatty acids, cholesterol, and ceramides are involved in key metabolic and inflammatory pathways underlying the pathogenesis of both diseases. Moreover, inflammation and lipid metabolism demonstrate close links in the comorbid course of NAFLD and COPD.Stanislav KotlyarovAleksei BulgakovMDPI AGarticlenon-alcoholic fatty liver diseaselipid metabolismmetabolismchronic obstructive pulmonary diseaseBiology (General)QH301-705.5ENCells, Vol 10, Iss 2978, p 2978 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-alcoholic fatty liver disease lipid metabolism metabolism chronic obstructive pulmonary disease Biology (General) QH301-705.5
spellingShingle	non-alcoholic fatty liver disease lipid metabolism metabolism chronic obstructive pulmonary disease Biology (General) QH301-705.5 Stanislav Kotlyarov Aleksei Bulgakov Lipid Metabolism Disorders in the Comorbid Course of Nonalcoholic Fatty Liver Disease and Chronic Obstructive Pulmonary Disease
description	Non-alcoholic fatty liver disease (NAFLD) is currently among the most common liver diseases. Unfavorable data on the epidemiology of metabolic syndrome and obesity have increased the attention of clinicians and researchers to the problem of NAFLD. The research results allow us to emphasize the systemicity and multifactoriality of the pathogenesis of liver parenchyma lesion. At the same time, many aspects of its classification, etiology, and pathogenesis remain controversial. Local and systemic metabolic disorders are also a part of the pathogenesis of chronic obstructive pulmonary disease and can influence its course. The present article analyzes the metabolic pathways mediating the links of impaired lipid metabolism in NAFLD and chronic obstructive pulmonary disease (COPD). Free fatty acids, cholesterol, and ceramides are involved in key metabolic and inflammatory pathways underlying the pathogenesis of both diseases. Moreover, inflammation and lipid metabolism demonstrate close links in the comorbid course of NAFLD and COPD.
format	article
author	Stanislav Kotlyarov Aleksei Bulgakov
author_facet	Stanislav Kotlyarov Aleksei Bulgakov
author_sort	Stanislav Kotlyarov
title	Lipid Metabolism Disorders in the Comorbid Course of Nonalcoholic Fatty Liver Disease and Chronic Obstructive Pulmonary Disease
title_short	Lipid Metabolism Disorders in the Comorbid Course of Nonalcoholic Fatty Liver Disease and Chronic Obstructive Pulmonary Disease
title_full	Lipid Metabolism Disorders in the Comorbid Course of Nonalcoholic Fatty Liver Disease and Chronic Obstructive Pulmonary Disease
title_fullStr	Lipid Metabolism Disorders in the Comorbid Course of Nonalcoholic Fatty Liver Disease and Chronic Obstructive Pulmonary Disease
title_full_unstemmed	Lipid Metabolism Disorders in the Comorbid Course of Nonalcoholic Fatty Liver Disease and Chronic Obstructive Pulmonary Disease
title_sort	lipid metabolism disorders in the comorbid course of nonalcoholic fatty liver disease and chronic obstructive pulmonary disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3e0208c3b72f43ba94f5cd4e667235cd
work_keys_str_mv	AT stanislavkotlyarov lipidmetabolismdisordersinthecomorbidcourseofnonalcoholicfattyliverdiseaseandchronicobstructivepulmonarydisease AT alekseibulgakov lipidmetabolismdisordersinthecomorbidcourseofnonalcoholicfattyliverdiseaseandchronicobstructivepulmonarydisease
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Lipid Metabolism Disorders in the Comorbid Course of Nonalcoholic Fatty Liver Disease and Chronic Obstructive Pulmonary Disease

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