Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity
Boosting immunity: How alum NETS improved vaccination Researchers have identified the mechanism of action in which aluminium hydroxide (alum) boosts the efficacy of co-administered vaccines. In this study, James Brewer and colleagues from the University of Glasgow, UK, studied the effects of alum co...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/3e041c4eb9374cf29ebd03d9b332dc46 |
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| Sumario: | Boosting immunity: How alum NETS improved vaccination Researchers have identified the mechanism of action in which aluminium hydroxide (alum) boosts the efficacy of co-administered vaccines. In this study, James Brewer and colleagues from the University of Glasgow, UK, studied the effects of alum co-administration in a mouse model, finding that the compound induces immune cells, called neutrophils, to swarm around the site of immunization and produce neutrophil extracellular traps (NETs). NETs, webs of DNA and cell contents formed under certain conditions of neutrophil cell death, immobilize pathogens and promote their elimination. This study builds on previous research and demonstrates that alum artificially stimulates this pathway to boost the adaptive immune response to vaccine antigens, increasing their immunogenicity. The authors also suggest further study into neutrophil components as potential therapeutic agents. |
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