Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity

Boosting immunity: How alum NETS improved vaccination Researchers have identified the mechanism of action in which aluminium hydroxide (alum) boosts the efficacy of co-administered vaccines. In this study, James Brewer and colleagues from the University of Glasgow, UK, studied the effects of alum co...

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Autores principales:	J. Stephen, H. E. Scales, R. A. Benson, D. Erben, P. Garside, J. M. Brewer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/3e041c4eb9374cf29ebd03d9b332dc46
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spelling	oai:doaj.org-article:3e041c4eb9374cf29ebd03d9b332dc462021-12-02T16:06:13ZNeutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity10.1038/s41541-016-0001-52059-0105https://doaj.org/article/3e041c4eb9374cf29ebd03d9b332dc462017-01-01T00:00:00Zhttps://doi.org/10.1038/s41541-016-0001-5https://doaj.org/toc/2059-0105Boosting immunity: How alum NETS improved vaccination Researchers have identified the mechanism of action in which aluminium hydroxide (alum) boosts the efficacy of co-administered vaccines. In this study, James Brewer and colleagues from the University of Glasgow, UK, studied the effects of alum co-administration in a mouse model, finding that the compound induces immune cells, called neutrophils, to swarm around the site of immunization and produce neutrophil extracellular traps (NETs). NETs, webs of DNA and cell contents formed under certain conditions of neutrophil cell death, immobilize pathogens and promote their elimination. This study builds on previous research and demonstrates that alum artificially stimulates this pathway to boost the adaptive immune response to vaccine antigens, increasing their immunogenicity. The authors also suggest further study into neutrophil components as potential therapeutic agents.J. StephenH. E. ScalesR. A. BensonD. ErbenP. GarsideJ. M. BrewerNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 2, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 J. Stephen H. E. Scales R. A. Benson D. Erben P. Garside J. M. Brewer Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity
description	Boosting immunity: How alum NETS improved vaccination Researchers have identified the mechanism of action in which aluminium hydroxide (alum) boosts the efficacy of co-administered vaccines. In this study, James Brewer and colleagues from the University of Glasgow, UK, studied the effects of alum co-administration in a mouse model, finding that the compound induces immune cells, called neutrophils, to swarm around the site of immunization and produce neutrophil extracellular traps (NETs). NETs, webs of DNA and cell contents formed under certain conditions of neutrophil cell death, immobilize pathogens and promote their elimination. This study builds on previous research and demonstrates that alum artificially stimulates this pathway to boost the adaptive immune response to vaccine antigens, increasing their immunogenicity. The authors also suggest further study into neutrophil components as potential therapeutic agents.
format	article
author	J. Stephen H. E. Scales R. A. Benson D. Erben P. Garside J. M. Brewer
author_facet	J. Stephen H. E. Scales R. A. Benson D. Erben P. Garside J. M. Brewer
author_sort	J. Stephen
title	Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity
title_short	Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity
title_full	Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity
title_fullStr	Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity
title_full_unstemmed	Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity
title_sort	neutrophil swarming and extracellular trap formation play a significant role in alum adjuvant activity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3e041c4eb9374cf29ebd03d9b332dc46
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Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity

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