A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers
Robert C Fang, Robert D GalianoDivision of Plastic and Reconstructive Surgery and Wound Healing Research Laboratory, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USAAbstract: Diabetic neuropathic foot ulcers represent a serious health care burden to patien...
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Dove Medical Press
2008
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oai:doaj.org-article:3e053306c47a418ab47b4587e015c9022021-12-02T03:10:40ZA review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers1177-54751177-5491https://doaj.org/article/3e053306c47a418ab47b4587e015c9022008-03-01T00:00:00Zhttp://www.dovepress.com/a-review-of-becaplermin-gel-in-the-treatment-of-diabetic-neuropathic-f-a49https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Robert C Fang, Robert D GalianoDivision of Plastic and Reconstructive Surgery and Wound Healing Research Laboratory, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USAAbstract: Diabetic neuropathic foot ulcers represent a serious health care burden to patients and to society. While the management of chronic diabetic foot ulcers has improved in recent years, it remains a frustrating problem for a variety of clinicians. This review examines the scientific underpinnings supporting the use of becaplermin (Regranex®; Ortho-McNeil Pharmaceutical, Raritan, NJ), or recombinant human platelet-derived growth factor (rhPDGF-BB), in diabetic forefoot wounds. An emphasis is placed upon proper medical and surgical care of diabetic foot wounds, as multiple studies have demonstrated that the success of this growth factor in accelerating healing is ultimately dependent on proper ulcer care. A focus on the cost-effectiveness of this form of therapy in the treatment of diabetic foot ulcers is also outlined.Keywords: becaplermin, diabetes, foot ulcer, growth factor Robert C FangRobert D GalianoDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2008, Iss Issue 1, Pp 1-12 (2008) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Medicine (General) R5-920 |
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Medicine (General) R5-920 Robert C Fang Robert D Galiano A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers |
| description |
Robert C Fang, Robert D GalianoDivision of Plastic and Reconstructive Surgery and Wound Healing Research Laboratory, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USAAbstract: Diabetic neuropathic foot ulcers represent a serious health care burden to patients and to society. While the management of chronic diabetic foot ulcers has improved in recent years, it remains a frustrating problem for a variety of clinicians. This review examines the scientific underpinnings supporting the use of becaplermin (Regranex®; Ortho-McNeil Pharmaceutical, Raritan, NJ), or recombinant human platelet-derived growth factor (rhPDGF-BB), in diabetic forefoot wounds. An emphasis is placed upon proper medical and surgical care of diabetic foot wounds, as multiple studies have demonstrated that the success of this growth factor in accelerating healing is ultimately dependent on proper ulcer care. A focus on the cost-effectiveness of this form of therapy in the treatment of diabetic foot ulcers is also outlined.Keywords: becaplermin, diabetes, foot ulcer, growth factor |
| format |
article |
| author |
Robert C Fang Robert D Galiano |
| author_facet |
Robert C Fang Robert D Galiano |
| author_sort |
Robert C Fang |
| title |
A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers |
| title_short |
A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers |
| title_full |
A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers |
| title_fullStr |
A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers |
| title_full_unstemmed |
A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers |
| title_sort |
review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers |
| publisher |
Dove Medical Press |
| publishDate |
2008 |
| url |
https://doaj.org/article/3e053306c47a418ab47b4587e015c902 |
| work_keys_str_mv |
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| _version_ |
1718401911923671040 |