Pure T-cell mediated rejection following kidney transplant according to response to treatment.

The focus of studies on kidney transplantation (KT) has largely shifted from T-cell mediated rejection (TCMR) to antibody-mediated rejection (ABMR). However, there are still cases of pure acute TCMR in histological reports, even after a long time following transplant. We thus evaluated the impact of...

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Autores principales:	Hyunwook Kwon, Young Hoon Kim, Youngmin Ko, Seong Jun Lim, Joo Hee Jung, Chung Hee Baek, Hyosang Kim, Su-Kil Park, Sung Shin, Yong-Pil Cho
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3e0b0f37327949bdb0d35e646e49d3af
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spelling	oai:doaj.org-article:3e0b0f37327949bdb0d35e646e49d3af2021-12-02T20:14:49ZPure T-cell mediated rejection following kidney transplant according to response to treatment.1932-620310.1371/journal.pone.0256898https://doaj.org/article/3e0b0f37327949bdb0d35e646e49d3af2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256898https://doaj.org/toc/1932-6203The focus of studies on kidney transplantation (KT) has largely shifted from T-cell mediated rejection (TCMR) to antibody-mediated rejection (ABMR). However, there are still cases of pure acute TCMR in histological reports, even after a long time following transplant. We thus evaluated the impact of pure TCMR on graft survival (GS) according to treatment response. We also performed molecular diagnosis using a molecular microscope diagnostic system on a separate group of 23 patients. A total of 63 patients were divided into non-responders (N = 22) and responders (N = 44). Non-response to rejection treatment was significantly associated with the following factors: glomerular filtration rate (GFR) at biopsy, ΔGFR, TCMR within one year, t score, and IF/TA score. We also found that non-responder vs. responder (OR = 3.31; P = 0.036) and lower GFR at biopsy (OR = 0.56; P = 0.026) were independent risk factors of graft failure. The responders had a significantly superior overall GS rate compared with the non-responders (P = 0.004). Molecular assessment showed a good correlation with histologic diagnosis in ABMR, but not in TCMR. Solitary TCMR was a significant risk factor of graft failure in patients who did not respond to rejection treatment.Hyunwook KwonYoung Hoon KimYoungmin KoSeong Jun LimJoo Hee JungChung Hee BaekHyosang KimSu-Kil ParkSung ShinYong-Pil ChoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0256898 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyunwook Kwon Young Hoon Kim Youngmin Ko Seong Jun Lim Joo Hee Jung Chung Hee Baek Hyosang Kim Su-Kil Park Sung Shin Yong-Pil Cho Pure T-cell mediated rejection following kidney transplant according to response to treatment.
description	The focus of studies on kidney transplantation (KT) has largely shifted from T-cell mediated rejection (TCMR) to antibody-mediated rejection (ABMR). However, there are still cases of pure acute TCMR in histological reports, even after a long time following transplant. We thus evaluated the impact of pure TCMR on graft survival (GS) according to treatment response. We also performed molecular diagnosis using a molecular microscope diagnostic system on a separate group of 23 patients. A total of 63 patients were divided into non-responders (N = 22) and responders (N = 44). Non-response to rejection treatment was significantly associated with the following factors: glomerular filtration rate (GFR) at biopsy, ΔGFR, TCMR within one year, t score, and IF/TA score. We also found that non-responder vs. responder (OR = 3.31; P = 0.036) and lower GFR at biopsy (OR = 0.56; P = 0.026) were independent risk factors of graft failure. The responders had a significantly superior overall GS rate compared with the non-responders (P = 0.004). Molecular assessment showed a good correlation with histologic diagnosis in ABMR, but not in TCMR. Solitary TCMR was a significant risk factor of graft failure in patients who did not respond to rejection treatment.
format	article
author	Hyunwook Kwon Young Hoon Kim Youngmin Ko Seong Jun Lim Joo Hee Jung Chung Hee Baek Hyosang Kim Su-Kil Park Sung Shin Yong-Pil Cho
author_facet	Hyunwook Kwon Young Hoon Kim Youngmin Ko Seong Jun Lim Joo Hee Jung Chung Hee Baek Hyosang Kim Su-Kil Park Sung Shin Yong-Pil Cho
author_sort	Hyunwook Kwon
title	Pure T-cell mediated rejection following kidney transplant according to response to treatment.
title_short	Pure T-cell mediated rejection following kidney transplant according to response to treatment.
title_full	Pure T-cell mediated rejection following kidney transplant according to response to treatment.
title_fullStr	Pure T-cell mediated rejection following kidney transplant according to response to treatment.
title_full_unstemmed	Pure T-cell mediated rejection following kidney transplant according to response to treatment.
title_sort	pure t-cell mediated rejection following kidney transplant according to response to treatment.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3e0b0f37327949bdb0d35e646e49d3af
work_keys_str_mv	AT hyunwookkwon puretcellmediatedrejectionfollowingkidneytransplantaccordingtoresponsetotreatment AT younghoonkim puretcellmediatedrejectionfollowingkidneytransplantaccordingtoresponsetotreatment AT youngminko puretcellmediatedrejectionfollowingkidneytransplantaccordingtoresponsetotreatment AT seongjunlim puretcellmediatedrejectionfollowingkidneytransplantaccordingtoresponsetotreatment AT jooheejung puretcellmediatedrejectionfollowingkidneytransplantaccordingtoresponsetotreatment AT chungheebaek puretcellmediatedrejectionfollowingkidneytransplantaccordingtoresponsetotreatment AT hyosangkim puretcellmediatedrejectionfollowingkidneytransplantaccordingtoresponsetotreatment AT sukilpark puretcellmediatedrejectionfollowingkidneytransplantaccordingtoresponsetotreatment AT sungshin puretcellmediatedrejectionfollowingkidneytransplantaccordingtoresponsetotreatment AT yongpilcho puretcellmediatedrejectionfollowingkidneytransplantaccordingtoresponsetotreatment
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Pure T-cell mediated rejection following kidney transplant according to response to treatment.

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