Controllable release of vascular endothelial growth factor (VEGF) by wheel spinning alginate/silk fibroin fibers for wound healing

The acute wound healing process requires a quick and short-stage vascular endothelial growth factor (VEGF) supply, especially, in the early-stage of injury. To date, research has rarely met the demand for controlled VEGF quick release. Herein, a novel wheel spinning technique was introduced to fabri...

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Autores principales:	Jun Song, Zhongda Chen, Zekun Liu, Yangpeiqi Yi, Olga Tsigkou, Jiashen Li, Yi Li
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Composite fiber Wet spinning Alginate Silk fibroin Growth factor Design of experiment Materials of engineering and construction. Mechanics of materials TA401-492
Acceso en línea:	https://doaj.org/article/3e0c1aa196bf4061b4fd56431dd68b66
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spelling	oai:doaj.org-article:3e0c1aa196bf4061b4fd56431dd68b662021-11-20T04:55:44ZControllable release of vascular endothelial growth factor (VEGF) by wheel spinning alginate/silk fibroin fibers for wound healing0264-127510.1016/j.matdes.2021.110231https://doaj.org/article/3e0c1aa196bf4061b4fd56431dd68b662021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0264127521007863https://doaj.org/toc/0264-1275The acute wound healing process requires a quick and short-stage vascular endothelial growth factor (VEGF) supply, especially, in the early-stage of injury. To date, research has rarely met the demand for controlled VEGF quick release. Herein, a novel wheel spinning technique was introduced to fabricate alginate (Alg)/silk fibroin (SF) composite fiber for loading VEGF and achieving controllable release. In turn, it was demonstrated that the parameter of wheel spinning and Alg/SF material morphological combination significantly influence VEGF release behavior and fiber degradation speed, which could be controlled by adjusting spinning solution concentration and modifying SF morphology. The loading concentration and SF structural features interacted with each other to affect the VEGF release behavior, indicating that growth factors such as VEGF could be released in a controllable fashion. It could therefore be developed as a novel approach to control the wound healing process.Jun SongZhongda ChenZekun LiuYangpeiqi YiOlga TsigkouJiashen LiYi LiElsevierarticleComposite fiberWet spinningAlginateSilk fibroinGrowth factorDesign of experimentMaterials of engineering and construction. Mechanics of materialsTA401-492ENMaterials & Design, Vol 212, Iss , Pp 110231- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Composite fiber Wet spinning Alginate Silk fibroin Growth factor Design of experiment Materials of engineering and construction. Mechanics of materials TA401-492
spellingShingle	Composite fiber Wet spinning Alginate Silk fibroin Growth factor Design of experiment Materials of engineering and construction. Mechanics of materials TA401-492 Jun Song Zhongda Chen Zekun Liu Yangpeiqi Yi Olga Tsigkou Jiashen Li Yi Li Controllable release of vascular endothelial growth factor (VEGF) by wheel spinning alginate/silk fibroin fibers for wound healing
description	The acute wound healing process requires a quick and short-stage vascular endothelial growth factor (VEGF) supply, especially, in the early-stage of injury. To date, research has rarely met the demand for controlled VEGF quick release. Herein, a novel wheel spinning technique was introduced to fabricate alginate (Alg)/silk fibroin (SF) composite fiber for loading VEGF and achieving controllable release. In turn, it was demonstrated that the parameter of wheel spinning and Alg/SF material morphological combination significantly influence VEGF release behavior and fiber degradation speed, which could be controlled by adjusting spinning solution concentration and modifying SF morphology. The loading concentration and SF structural features interacted with each other to affect the VEGF release behavior, indicating that growth factors such as VEGF could be released in a controllable fashion. It could therefore be developed as a novel approach to control the wound healing process.
format	article
author	Jun Song Zhongda Chen Zekun Liu Yangpeiqi Yi Olga Tsigkou Jiashen Li Yi Li
author_facet	Jun Song Zhongda Chen Zekun Liu Yangpeiqi Yi Olga Tsigkou Jiashen Li Yi Li
author_sort	Jun Song
title	Controllable release of vascular endothelial growth factor (VEGF) by wheel spinning alginate/silk fibroin fibers for wound healing
title_short	Controllable release of vascular endothelial growth factor (VEGF) by wheel spinning alginate/silk fibroin fibers for wound healing
title_full	Controllable release of vascular endothelial growth factor (VEGF) by wheel spinning alginate/silk fibroin fibers for wound healing
title_fullStr	Controllable release of vascular endothelial growth factor (VEGF) by wheel spinning alginate/silk fibroin fibers for wound healing
title_full_unstemmed	Controllable release of vascular endothelial growth factor (VEGF) by wheel spinning alginate/silk fibroin fibers for wound healing
title_sort	controllable release of vascular endothelial growth factor (vegf) by wheel spinning alginate/silk fibroin fibers for wound healing
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/3e0c1aa196bf4061b4fd56431dd68b66
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Controllable release of vascular endothelial growth factor (VEGF) by wheel spinning alginate/silk fibroin fibers for wound healing

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