Searching large-scale scRNA-seq databases via unbiased cell embedding with Cell BLAST

Single-cell RNA-seq (scRNA-seq) is being widely used to resolve cellular heterogeneity. Here, the authors present a cell-querying method built on a neural network-based generative model and a customized cell-to-cell similarity metric.

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Detalles Bibliográficos
Autores principales: Zhi-Jie Cao, Lin Wei, Shen Lu, De-Chang Yang, Ge Gao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/3e0cf5f83c044e5689b8ee6fcaa6bccd
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Descripción
Sumario:Single-cell RNA-seq (scRNA-seq) is being widely used to resolve cellular heterogeneity. Here, the authors present a cell-querying method built on a neural network-based generative model and a customized cell-to-cell similarity metric.