Exploring the Serum Level of RE1 Silencing Transcription Factor in Alzheimer’s Disease

Objective The aim of this study was to evaluate the serum RE1 silencing transcription factor (REST) level in Alzheimer’s disease (AD), mild cognitive impairment (MCI), and elderly controls by using surface plasmon resonance (SPR) technology. Materials and Methods In this case–control stud...

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Autores principales:	Shashank Shekhar, Manjari Tripathi, A. B. Dey, Sharmistha Dey
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2021
Materias:	alzheimer’s disease serum re1 silencing transcription factor mild cognitive impairment surface plasmon resonance General works R5-130.5 Science Q
Acceso en línea:	https://doaj.org/article/3e0edb7d0a09496186c9c801ccf532ad
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spelling	oai:doaj.org-article:3e0edb7d0a09496186c9c801ccf532ad2021-11-08T23:59:10ZExploring the Serum Level of RE1 Silencing Transcription Factor in Alzheimer’s Disease0379-038X2454-563510.1055/s-0041-1731970https://doaj.org/article/3e0edb7d0a09496186c9c801ccf532ad2021-11-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1731970https://doaj.org/toc/0379-038Xhttps://doaj.org/toc/2454-5635Objective The aim of this study was to evaluate the serum RE1 silencing transcription factor (REST) level in Alzheimer’s disease (AD), mild cognitive impairment (MCI), and elderly controls by using surface plasmon resonance (SPR) technology. Materials and Methods In this case–control study of 133 subjects, 49 patients with AD, 49 patients with MCI, and 35 elderly controls were recruited. The REST protein concentrations were evaluated by SPR. The resonance unit for each sample was recorded and the concentration of serum REST of study group was derived from the standard curve. All the experiments were done in triplicates. Statistical analysis was done and p-value of < 0.05 was considered as statistically significant. Results A significant difference was observed in the Montreal Cognitive Assessment score, Hindi Mental State Examination scale (HMSE) score education, disease duration, and gender among the groups. A significant (p>0.0001) difference in the duration of disease between AD and MCI was observed. It was observed that the mean concentration of serum REST was not significantly (p = 0.266) different among the groups. Conclusion This study first time evaluated the serum levels of REST in AD, MCI and age-matched elderly controls. The rest levels were similar in all groups; however, it can provide a new direction to future blood-based biomarker studies of REST.Shashank ShekharManjari TripathiA. B. DeySharmistha DeyThieme Medical and Scientific Publishers Pvt. Ltd.articlealzheimer’s diseaseserumre1 silencing transcription factormild cognitive impairmentsurface plasmon resonanceGeneral worksR5-130.5ScienceQENAnnals of the National Academy of Medical Sciences (India) (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alzheimer’s disease serum re1 silencing transcription factor mild cognitive impairment surface plasmon resonance General works R5-130.5 Science Q
spellingShingle	alzheimer’s disease serum re1 silencing transcription factor mild cognitive impairment surface plasmon resonance General works R5-130.5 Science Q Shashank Shekhar Manjari Tripathi A. B. Dey Sharmistha Dey Exploring the Serum Level of RE1 Silencing Transcription Factor in Alzheimer’s Disease
description	Objective The aim of this study was to evaluate the serum RE1 silencing transcription factor (REST) level in Alzheimer’s disease (AD), mild cognitive impairment (MCI), and elderly controls by using surface plasmon resonance (SPR) technology. Materials and Methods In this case–control study of 133 subjects, 49 patients with AD, 49 patients with MCI, and 35 elderly controls were recruited. The REST protein concentrations were evaluated by SPR. The resonance unit for each sample was recorded and the concentration of serum REST of study group was derived from the standard curve. All the experiments were done in triplicates. Statistical analysis was done and p-value of < 0.05 was considered as statistically significant. Results A significant difference was observed in the Montreal Cognitive Assessment score, Hindi Mental State Examination scale (HMSE) score education, disease duration, and gender among the groups. A significant (p>0.0001) difference in the duration of disease between AD and MCI was observed. It was observed that the mean concentration of serum REST was not significantly (p = 0.266) different among the groups. Conclusion This study first time evaluated the serum levels of REST in AD, MCI and age-matched elderly controls. The rest levels were similar in all groups; however, it can provide a new direction to future blood-based biomarker studies of REST.
format	article
author	Shashank Shekhar Manjari Tripathi A. B. Dey Sharmistha Dey
author_facet	Shashank Shekhar Manjari Tripathi A. B. Dey Sharmistha Dey
author_sort	Shashank Shekhar
title	Exploring the Serum Level of RE1 Silencing Transcription Factor in Alzheimer’s Disease
title_short	Exploring the Serum Level of RE1 Silencing Transcription Factor in Alzheimer’s Disease
title_full	Exploring the Serum Level of RE1 Silencing Transcription Factor in Alzheimer’s Disease
title_fullStr	Exploring the Serum Level of RE1 Silencing Transcription Factor in Alzheimer’s Disease
title_full_unstemmed	Exploring the Serum Level of RE1 Silencing Transcription Factor in Alzheimer’s Disease
title_sort	exploring the serum level of re1 silencing transcription factor in alzheimer’s disease
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2021
url	https://doaj.org/article/3e0edb7d0a09496186c9c801ccf532ad
work_keys_str_mv	AT shashankshekhar exploringtheserumlevelofre1silencingtranscriptionfactorinalzheimersdisease AT manjaritripathi exploringtheserumlevelofre1silencingtranscriptionfactorinalzheimersdisease AT abdey exploringtheserumlevelofre1silencingtranscriptionfactorinalzheimersdisease AT sharmisthadey exploringtheserumlevelofre1silencingtranscriptionfactorinalzheimersdisease
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Exploring the Serum Level of RE1 Silencing Transcription Factor in Alzheimer’s Disease

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