Comparison of Clotrimazole and Boric Acid in Treatment of Complicated Vulvovaginal Candidiasis

BACKGROUND AND OBJECTIVE: Vulvovaginal candidiasis is a frequent disease among women and the complicated one is more resistant to treatment. It has a high recurrence rate. This study was carried out to compare two treatment regimens: intravaginal clotimazole and boric acid for treatment and recurren...

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Autores principales:	M Zeinalzadeh, M Mohammadian Amiri, Z Basirat, M Sharbatdaran, M Aklamli, A Bijani
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2009
Materias:	candidasis clotrimazole boric acid vulvovaginitis Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3e1271cfbb0c45998489de1fb543b44c
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spelling	oai:doaj.org-article:3e1271cfbb0c45998489de1fb543b44c2021-11-10T09:02:52ZComparison of Clotrimazole and Boric Acid in Treatment of Complicated Vulvovaginal Candidiasis1561-41072251-7170https://doaj.org/article/3e1271cfbb0c45998489de1fb543b44c2009-08-01T00:00:00Zhttp://jbums.org/article-1-3220-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Vulvovaginal candidiasis is a frequent disease among women and the complicated one is more resistant to treatment. It has a high recurrence rate. This study was carried out to compare two treatment regimens: intravaginal clotimazole and boric acid for treatment and recurrence rate of complicated vulvovaginitis.METHODS: This clinical trial study was performed on 60 women with clinical and mycological evidence of complicated vaginal candidiasis that referred to Yahyanejad hospital, Babol, Iran. They were randomized to receive daily intravaginal boric acid for 14 days (30 women) or daily intravaginal clotrimazole for 14 days (30 women). They were assessed 1 month and 3 months after treatment and compared together. FINDINGS: Twenty three patients (76.7%) was cured clinically for inflammation and 25 patients (83.3%) for discharge and 18 patients (60%) microscopically in clotrimazole group and 24 patients (80%) was cured clinically for inflammation and discharge and 19 patients (63.3%) microscopically in boric acid group. The rate of microscopically recurrence was 7 patients (38.9%) in clotrimazole group and 5 patients (26.3%) in boric acid group. These differences were not statistically significant.CONCLUSION: The study suggests that boric acid or clotrimazole is effective in treatment and recurrence of complicated vaginal candidasis. It is more cost effective to use boric acid.M Zeinalzadeh,M Mohammadian AmiriZ BasiratM Sharbatdaran,M Aklamli,A BijaniBabol University of Medical Sciencesarticlecandidasisclotrimazoleboric acidvulvovaginitisMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 11, Iss 3, Pp 26-31 (2009)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	candidasis clotrimazole boric acid vulvovaginitis Medicine R Medicine (General) R5-920
spellingShingle	candidasis clotrimazole boric acid vulvovaginitis Medicine R Medicine (General) R5-920 M Zeinalzadeh, M Mohammadian Amiri Z Basirat M Sharbatdaran, M Aklamli, A Bijani Comparison of Clotrimazole and Boric Acid in Treatment of Complicated Vulvovaginal Candidiasis
description	BACKGROUND AND OBJECTIVE: Vulvovaginal candidiasis is a frequent disease among women and the complicated one is more resistant to treatment. It has a high recurrence rate. This study was carried out to compare two treatment regimens: intravaginal clotimazole and boric acid for treatment and recurrence rate of complicated vulvovaginitis.METHODS: This clinical trial study was performed on 60 women with clinical and mycological evidence of complicated vaginal candidiasis that referred to Yahyanejad hospital, Babol, Iran. They were randomized to receive daily intravaginal boric acid for 14 days (30 women) or daily intravaginal clotrimazole for 14 days (30 women). They were assessed 1 month and 3 months after treatment and compared together. FINDINGS: Twenty three patients (76.7%) was cured clinically for inflammation and 25 patients (83.3%) for discharge and 18 patients (60%) microscopically in clotrimazole group and 24 patients (80%) was cured clinically for inflammation and discharge and 19 patients (63.3%) microscopically in boric acid group. The rate of microscopically recurrence was 7 patients (38.9%) in clotrimazole group and 5 patients (26.3%) in boric acid group. These differences were not statistically significant.CONCLUSION: The study suggests that boric acid or clotrimazole is effective in treatment and recurrence of complicated vaginal candidasis. It is more cost effective to use boric acid.
format	article
author	M Zeinalzadeh, M Mohammadian Amiri Z Basirat M Sharbatdaran, M Aklamli, A Bijani
author_facet	M Zeinalzadeh, M Mohammadian Amiri Z Basirat M Sharbatdaran, M Aklamli, A Bijani
author_sort	M Zeinalzadeh,
title	Comparison of Clotrimazole and Boric Acid in Treatment of Complicated Vulvovaginal Candidiasis
title_short	Comparison of Clotrimazole and Boric Acid in Treatment of Complicated Vulvovaginal Candidiasis
title_full	Comparison of Clotrimazole and Boric Acid in Treatment of Complicated Vulvovaginal Candidiasis
title_fullStr	Comparison of Clotrimazole and Boric Acid in Treatment of Complicated Vulvovaginal Candidiasis
title_full_unstemmed	Comparison of Clotrimazole and Boric Acid in Treatment of Complicated Vulvovaginal Candidiasis
title_sort	comparison of clotrimazole and boric acid in treatment of complicated vulvovaginal candidiasis
publisher	Babol University of Medical Sciences
publishDate	2009
url	https://doaj.org/article/3e1271cfbb0c45998489de1fb543b44c
work_keys_str_mv	AT mzeinalzadeh comparisonofclotrimazoleandboricacidintreatmentofcomplicatedvulvovaginalcandidiasis AT mmohammadianamiri comparisonofclotrimazoleandboricacidintreatmentofcomplicatedvulvovaginalcandidiasis AT zbasirat comparisonofclotrimazoleandboricacidintreatmentofcomplicatedvulvovaginalcandidiasis AT msharbatdaran comparisonofclotrimazoleandboricacidintreatmentofcomplicatedvulvovaginalcandidiasis AT maklamli comparisonofclotrimazoleandboricacidintreatmentofcomplicatedvulvovaginalcandidiasis AT abijani comparisonofclotrimazoleandboricacidintreatmentofcomplicatedvulvovaginalcandidiasis
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Comparison of Clotrimazole and Boric Acid in Treatment of Complicated Vulvovaginal Candidiasis

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