Ferulic acid suppresses obesity and obesity-related metabolic syndromes in high fat diet-induced obese C57BL/6J mice

This study aimed to determine whether mice fed ferulic acid (FA) would alleviate high-fat diet-induced obesity and obesity-related metabolic syndromes. Mice were divided into the following four groups and fed for 6 wk (n = 8): control diet (NC), high-fat diet (HF; 60% energy from fat), NC and HF sup...

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Autores principales:	Weiwei Wang, Yiou Pan, Hang Zhou, Li Wang, Xi Chen, Ge Song, Jianxue Liu, Aike Li
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	ferulic acid high-fat diet metabolic syndrome mice obesity Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/3e1673af5f6e477898104e1b7f3d41c9
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spelling	oai:doaj.org-article:3e1673af5f6e477898104e1b7f3d41c92021-11-26T11:19:47ZFerulic acid suppresses obesity and obesity-related metabolic syndromes in high fat diet-induced obese C57BL/6J mice0954-01051465-344310.1080/09540105.2018.1516739https://doaj.org/article/3e1673af5f6e477898104e1b7f3d41c92018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2018.1516739https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443This study aimed to determine whether mice fed ferulic acid (FA) would alleviate high-fat diet-induced obesity and obesity-related metabolic syndromes. Mice were divided into the following four groups and fed for 6 wk (n = 8): control diet (NC), high-fat diet (HF; 60% energy from fat), NC and HF supplemented with 0.5% (w/w) FA respectively. Mice fed HF-FA diet consumed same amount of energy, but had lower daily weight gain, white adipose tissue weight, body fat accumulation, blood glucose and had suppressed hepatic lipid accumulation and inflammatory cytokines (IL-6 and TNF-α) release (P < 0.05), compared with those in HF-fed mice. In conclusion, our findings indicate that dietary FA supplementation suppress body weight gain, body and hepatic fat accumulation, blood glucose elevation and inflammation in high fat diet-induced obese mice, suggesting that FA could be effective in lowering the risk of high fat-diet induced obesity and obesity-related metabolic syndromes.Weiwei WangYiou PanHang ZhouLi WangXi ChenGe SongJianxue LiuAike LiTaylor & Francis Grouparticleferulic acidhigh-fat dietmetabolic syndromemiceobesityAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 1116-1125 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	ferulic acid high-fat diet metabolic syndrome mice obesity Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	ferulic acid high-fat diet metabolic syndrome mice obesity Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Weiwei Wang Yiou Pan Hang Zhou Li Wang Xi Chen Ge Song Jianxue Liu Aike Li Ferulic acid suppresses obesity and obesity-related metabolic syndromes in high fat diet-induced obese C57BL/6J mice
description	This study aimed to determine whether mice fed ferulic acid (FA) would alleviate high-fat diet-induced obesity and obesity-related metabolic syndromes. Mice were divided into the following four groups and fed for 6 wk (n = 8): control diet (NC), high-fat diet (HF; 60% energy from fat), NC and HF supplemented with 0.5% (w/w) FA respectively. Mice fed HF-FA diet consumed same amount of energy, but had lower daily weight gain, white adipose tissue weight, body fat accumulation, blood glucose and had suppressed hepatic lipid accumulation and inflammatory cytokines (IL-6 and TNF-α) release (P < 0.05), compared with those in HF-fed mice. In conclusion, our findings indicate that dietary FA supplementation suppress body weight gain, body and hepatic fat accumulation, blood glucose elevation and inflammation in high fat diet-induced obese mice, suggesting that FA could be effective in lowering the risk of high fat-diet induced obesity and obesity-related metabolic syndromes.
format	article
author	Weiwei Wang Yiou Pan Hang Zhou Li Wang Xi Chen Ge Song Jianxue Liu Aike Li
author_facet	Weiwei Wang Yiou Pan Hang Zhou Li Wang Xi Chen Ge Song Jianxue Liu Aike Li
author_sort	Weiwei Wang
title	Ferulic acid suppresses obesity and obesity-related metabolic syndromes in high fat diet-induced obese C57BL/6J mice
title_short	Ferulic acid suppresses obesity and obesity-related metabolic syndromes in high fat diet-induced obese C57BL/6J mice
title_full	Ferulic acid suppresses obesity and obesity-related metabolic syndromes in high fat diet-induced obese C57BL/6J mice
title_fullStr	Ferulic acid suppresses obesity and obesity-related metabolic syndromes in high fat diet-induced obese C57BL/6J mice
title_full_unstemmed	Ferulic acid suppresses obesity and obesity-related metabolic syndromes in high fat diet-induced obese C57BL/6J mice
title_sort	ferulic acid suppresses obesity and obesity-related metabolic syndromes in high fat diet-induced obese c57bl/6j mice
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/3e1673af5f6e477898104e1b7f3d41c9
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Ferulic acid suppresses obesity and obesity-related metabolic syndromes in high fat diet-induced obese C57BL/6J mice

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