Pan-cancer landscape of homologous recombination deficiency

Cancers deficient in homologous recombination can benefit from treatment with poly ADP-ribose polymerase (PARP) inhibitors. Here, the authors generated a classifier that can predict homologous recombination deficiency from genomic data and suggest several cancer types that may benefit from PARP inhi...

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Autores principales:	Luan Nguyen, John W. M. Martens, Arne Van Hoeck, Edwin Cuppen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e18fff65acc4455b9f7724c9219a647
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spelling	oai:doaj.org-article:3e18fff65acc4455b9f7724c9219a6472021-12-02T15:39:24ZPan-cancer landscape of homologous recombination deficiency10.1038/s41467-020-19406-42041-1723https://doaj.org/article/3e18fff65acc4455b9f7724c9219a6472020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19406-4https://doaj.org/toc/2041-1723Cancers deficient in homologous recombination can benefit from treatment with poly ADP-ribose polymerase (PARP) inhibitors. Here, the authors generated a classifier that can predict homologous recombination deficiency from genomic data and suggest several cancer types that may benefit from PARP inhibitor treatment.Luan NguyenJohn W. M. MartensArne Van HoeckEdwin CuppenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luan Nguyen John W. M. Martens Arne Van Hoeck Edwin Cuppen Pan-cancer landscape of homologous recombination deficiency
description	Cancers deficient in homologous recombination can benefit from treatment with poly ADP-ribose polymerase (PARP) inhibitors. Here, the authors generated a classifier that can predict homologous recombination deficiency from genomic data and suggest several cancer types that may benefit from PARP inhibitor treatment.
format	article
author	Luan Nguyen John W. M. Martens Arne Van Hoeck Edwin Cuppen
author_facet	Luan Nguyen John W. M. Martens Arne Van Hoeck Edwin Cuppen
author_sort	Luan Nguyen
title	Pan-cancer landscape of homologous recombination deficiency
title_short	Pan-cancer landscape of homologous recombination deficiency
title_full	Pan-cancer landscape of homologous recombination deficiency
title_fullStr	Pan-cancer landscape of homologous recombination deficiency
title_full_unstemmed	Pan-cancer landscape of homologous recombination deficiency
title_sort	pan-cancer landscape of homologous recombination deficiency
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3e18fff65acc4455b9f7724c9219a647
work_keys_str_mv	AT luannguyen pancancerlandscapeofhomologousrecombinationdeficiency AT johnwmmartens pancancerlandscapeofhomologousrecombinationdeficiency AT arnevanhoeck pancancerlandscapeofhomologousrecombinationdeficiency AT edwincuppen pancancerlandscapeofhomologousrecombinationdeficiency
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Pan-cancer landscape of homologous recombination deficiency

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