Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases – a comparative study of leishmaniasis and sporotrichosis

Abstract The clinical presentations of skin diseases produced by different pathogens, as American tegumentary leishmaniasis (ATL) and sporotrichosis can be similar and possibly influenced by the skin immune system (SIS). The aim of the study was to understand the underlying mechanisms of skin inflam...

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Autores principales:	F. N. Morgado, L. M. V. de Carvalho, J. Leite-Silva, A. J. Seba, M. I. F. Pimentel, A. Fagundes, M. F. Madeira, M. R. Lyra, M. M. Oliveira, A. O. Schubach, F. Conceição-Silva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3e1a4b23c850435f82be61c1be2b08ad
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spelling	oai:doaj.org-article:3e1a4b23c850435f82be61c1be2b08ad2021-12-02T15:09:01ZUnbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases – a comparative study of leishmaniasis and sporotrichosis10.1038/s41598-018-21277-12045-2322https://doaj.org/article/3e1a4b23c850435f82be61c1be2b08ad2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21277-1https://doaj.org/toc/2045-2322Abstract The clinical presentations of skin diseases produced by different pathogens, as American tegumentary leishmaniasis (ATL) and sporotrichosis can be similar and possibly influenced by the skin immune system (SIS). The aim of the study was to understand the underlying mechanisms of skin inflammation produced by different pathogens. We used immunohistochemistry to analyze 96 patients: a- localized cutaneous leishmaniasis (LCL-ATL); b- sporotrichoid cutaneous leishmaniasis (SCL-ATL); c-lymphocutaneous (LC-SP); d- fixed (F-SP) sporotrichosis. LCL-ATL and SCL-ATL had a significantly higher percentage of CD8, FasL and NOS2 than sporotrichosis. In contrast, LC-SP had a substantially higher percentage of CD4, BCl2 and neutrophils than ATL lesions. These results indicated some differences in the profile of the in situ immune response suggesting that SIS is a complex, adaptable system capable of different responses to intracellular or extracellular pathogens. However, regardless of the etiological agents, the inflammatory reaction and clinical manifestations can be similar. SCL-ATL and LC-SP presented similarities in both clinical presentation and in situ inflammatory profile (CD3, CD22, neutrophils, macrophages). The clinical presentation of ATL and sporotrichosis could be explained by a combination of factors both of the host SIS and the etiological agent. The unbalanced host parasite relationship could result in atypical manifestations of skin disease.F. N. MorgadoL. M. V. de CarvalhoJ. Leite-SilvaA. J. SebaM. I. F. PimentelA. FagundesM. F. MadeiraM. R. LyraM. M. OliveiraA. O. SchubachF. Conceição-SilvaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q F. N. Morgado L. M. V. de Carvalho J. Leite-Silva A. J. Seba M. I. F. Pimentel A. Fagundes M. F. Madeira M. R. Lyra M. M. Oliveira A. O. Schubach F. Conceição-Silva Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases – a comparative study of leishmaniasis and sporotrichosis
description	Abstract The clinical presentations of skin diseases produced by different pathogens, as American tegumentary leishmaniasis (ATL) and sporotrichosis can be similar and possibly influenced by the skin immune system (SIS). The aim of the study was to understand the underlying mechanisms of skin inflammation produced by different pathogens. We used immunohistochemistry to analyze 96 patients: a- localized cutaneous leishmaniasis (LCL-ATL); b- sporotrichoid cutaneous leishmaniasis (SCL-ATL); c-lymphocutaneous (LC-SP); d- fixed (F-SP) sporotrichosis. LCL-ATL and SCL-ATL had a significantly higher percentage of CD8, FasL and NOS2 than sporotrichosis. In contrast, LC-SP had a substantially higher percentage of CD4, BCl2 and neutrophils than ATL lesions. These results indicated some differences in the profile of the in situ immune response suggesting that SIS is a complex, adaptable system capable of different responses to intracellular or extracellular pathogens. However, regardless of the etiological agents, the inflammatory reaction and clinical manifestations can be similar. SCL-ATL and LC-SP presented similarities in both clinical presentation and in situ inflammatory profile (CD3, CD22, neutrophils, macrophages). The clinical presentation of ATL and sporotrichosis could be explained by a combination of factors both of the host SIS and the etiological agent. The unbalanced host parasite relationship could result in atypical manifestations of skin disease.
format	article
author	F. N. Morgado L. M. V. de Carvalho J. Leite-Silva A. J. Seba M. I. F. Pimentel A. Fagundes M. F. Madeira M. R. Lyra M. M. Oliveira A. O. Schubach F. Conceição-Silva
author_facet	F. N. Morgado L. M. V. de Carvalho J. Leite-Silva A. J. Seba M. I. F. Pimentel A. Fagundes M. F. Madeira M. R. Lyra M. M. Oliveira A. O. Schubach F. Conceição-Silva
author_sort	F. N. Morgado
title	Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases – a comparative study of leishmaniasis and sporotrichosis
title_short	Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases – a comparative study of leishmaniasis and sporotrichosis
title_full	Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases – a comparative study of leishmaniasis and sporotrichosis
title_fullStr	Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases – a comparative study of leishmaniasis and sporotrichosis
title_full_unstemmed	Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases – a comparative study of leishmaniasis and sporotrichosis
title_sort	unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases – a comparative study of leishmaniasis and sporotrichosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3e1a4b23c850435f82be61c1be2b08ad
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Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases – a comparative study of leishmaniasis and sporotrichosis

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