A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism

Human liver chimeric mice are increasingly used for drug testing in preclinical development, but express residual murine p450 cytochromes. Here the authors generate mice lacking the Por gene in the liver, and show that human cytochrome metabolism is used following repopulation with human hepatocytes...

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Autores principales:	Mercedes Barzi, Francis P. Pankowicz, Barry Zorman, Xing Liu, Xavier Legras, Diane Yang, Malgorzata Borowiak, Beatrice Bissig-Choisat, Pavel Sumazin, Feng Li, Karl-Dimiter Bissig
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e218892915b40fa9da11819b0704336
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spelling	oai:doaj.org-article:3e218892915b40fa9da11819b07043362021-12-02T10:48:19ZA novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism10.1038/s41467-017-00049-x2041-1723https://doaj.org/article/3e218892915b40fa9da11819b07043362017-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00049-xhttps://doaj.org/toc/2041-1723Human liver chimeric mice are increasingly used for drug testing in preclinical development, but express residual murine p450 cytochromes. Here the authors generate mice lacking the Por gene in the liver, and show that human cytochrome metabolism is used following repopulation with human hepatocytes.Mercedes BarziFrancis P. PankowiczBarry ZormanXing LiuXavier LegrasDiane YangMalgorzata BorowiakBeatrice Bissig-ChoisatPavel SumazinFeng LiKarl-Dimiter BissigNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mercedes Barzi Francis P. Pankowicz Barry Zorman Xing Liu Xavier Legras Diane Yang Malgorzata Borowiak Beatrice Bissig-Choisat Pavel Sumazin Feng Li Karl-Dimiter Bissig A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism
description	Human liver chimeric mice are increasingly used for drug testing in preclinical development, but express residual murine p450 cytochromes. Here the authors generate mice lacking the Por gene in the liver, and show that human cytochrome metabolism is used following repopulation with human hepatocytes.
format	article
author	Mercedes Barzi Francis P. Pankowicz Barry Zorman Xing Liu Xavier Legras Diane Yang Malgorzata Borowiak Beatrice Bissig-Choisat Pavel Sumazin Feng Li Karl-Dimiter Bissig
author_facet	Mercedes Barzi Francis P. Pankowicz Barry Zorman Xing Liu Xavier Legras Diane Yang Malgorzata Borowiak Beatrice Bissig-Choisat Pavel Sumazin Feng Li Karl-Dimiter Bissig
author_sort	Mercedes Barzi
title	A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism
title_short	A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism
title_full	A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism
title_fullStr	A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism
title_full_unstemmed	A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism
title_sort	novel humanized mouse lacking murine p450 oxidoreductase for studying human drug metabolism
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3e218892915b40fa9da11819b0704336
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A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism

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