A New Take on an Old Remedy: Generating Antibodies against Multidrug-Resistant Gram-Negative Bacteria in a Postantibiotic World

ABSTRACT With the problem of multidrug-resistant Gram-negative pathogens becoming increasingly dire, new strategies are needed to protect and treat infected patients. Though abandoned in the past, monoclonal antibody therapy against Gram-negative bacteria remains a potential solution and has potenti...

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Autores principales:	Michael P. Motley, Bettina C. Fries
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	Acinetobacter Enterobacteriaceae Escherichia coli Klebsiella ST258 MAb therapy Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/3e22e454abf64b0ca2814e97e32cc264
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spelling	oai:doaj.org-article:3e22e454abf64b0ca2814e97e32cc2642021-11-15T15:22:05ZA New Take on an Old Remedy: Generating Antibodies against Multidrug-Resistant Gram-Negative Bacteria in a Postantibiotic World10.1128/mSphere.00397-172379-5042https://doaj.org/article/3e22e454abf64b0ca2814e97e32cc2642017-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00397-17https://doaj.org/toc/2379-5042ABSTRACT With the problem of multidrug-resistant Gram-negative pathogens becoming increasingly dire, new strategies are needed to protect and treat infected patients. Though abandoned in the past, monoclonal antibody therapy against Gram-negative bacteria remains a potential solution and has potential advantages over the broad-spectrum antibiotics they were once replaced by. This Perspective reviews the prospect of utilizing monoclonal antibody therapy against these pathogens, as well as the challenges of doing so and the current therapy targets under investigation.Michael P. MotleyBettina C. FriesAmerican Society for MicrobiologyarticleAcinetobacterEnterobacteriaceaeEscherichia coliKlebsiellaST258MAb therapyMicrobiologyQR1-502ENmSphere, Vol 2, Iss 5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acinetobacter Enterobacteriaceae Escherichia coli Klebsiella ST258 MAb therapy Microbiology QR1-502
spellingShingle	Acinetobacter Enterobacteriaceae Escherichia coli Klebsiella ST258 MAb therapy Microbiology QR1-502 Michael P. Motley Bettina C. Fries A New Take on an Old Remedy: Generating Antibodies against Multidrug-Resistant Gram-Negative Bacteria in a Postantibiotic World
description	ABSTRACT With the problem of multidrug-resistant Gram-negative pathogens becoming increasingly dire, new strategies are needed to protect and treat infected patients. Though abandoned in the past, monoclonal antibody therapy against Gram-negative bacteria remains a potential solution and has potential advantages over the broad-spectrum antibiotics they were once replaced by. This Perspective reviews the prospect of utilizing monoclonal antibody therapy against these pathogens, as well as the challenges of doing so and the current therapy targets under investigation.
format	article
author	Michael P. Motley Bettina C. Fries
author_facet	Michael P. Motley Bettina C. Fries
author_sort	Michael P. Motley
title	A New Take on an Old Remedy: Generating Antibodies against Multidrug-Resistant Gram-Negative Bacteria in a Postantibiotic World
title_short	A New Take on an Old Remedy: Generating Antibodies against Multidrug-Resistant Gram-Negative Bacteria in a Postantibiotic World
title_full	A New Take on an Old Remedy: Generating Antibodies against Multidrug-Resistant Gram-Negative Bacteria in a Postantibiotic World
title_fullStr	A New Take on an Old Remedy: Generating Antibodies against Multidrug-Resistant Gram-Negative Bacteria in a Postantibiotic World
title_full_unstemmed	A New Take on an Old Remedy: Generating Antibodies against Multidrug-Resistant Gram-Negative Bacteria in a Postantibiotic World
title_sort	new take on an old remedy: generating antibodies against multidrug-resistant gram-negative bacteria in a postantibiotic world
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/3e22e454abf64b0ca2814e97e32cc264
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A New Take on an Old Remedy: Generating Antibodies against Multidrug-Resistant Gram-Negative Bacteria in a Postantibiotic World

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