A systematic approach to orient the human protein–protein interaction network

The directions of most human protein-protein interactions (PPIs) remain unknown. Here, the authors use cancer genomic and drug response data to infer the direction of signal flow in the human PPI network and show that the directed network improves drug target and cancer driver gene prioritization.

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Detalles Bibliográficos
Autores principales:	Dana Silverbush, Roded Sharan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e25d3924d584a10ba7554732fedb711
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id	oai:doaj.org-article:3e25d3924d584a10ba7554732fedb711
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spelling	oai:doaj.org-article:3e25d3924d584a10ba7554732fedb7112021-12-02T17:01:32ZA systematic approach to orient the human protein–protein interaction network10.1038/s41467-019-10887-62041-1723https://doaj.org/article/3e25d3924d584a10ba7554732fedb7112019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10887-6https://doaj.org/toc/2041-1723The directions of most human protein-protein interactions (PPIs) remain unknown. Here, the authors use cancer genomic and drug response data to infer the direction of signal flow in the human PPI network and show that the directed network improves drug target and cancer driver gene prioritization.Dana SilverbushRoded SharanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dana Silverbush Roded Sharan A systematic approach to orient the human protein–protein interaction network
description	The directions of most human protein-protein interactions (PPIs) remain unknown. Here, the authors use cancer genomic and drug response data to infer the direction of signal flow in the human PPI network and show that the directed network improves drug target and cancer driver gene prioritization.
format	article
author	Dana Silverbush Roded Sharan
author_facet	Dana Silverbush Roded Sharan
author_sort	Dana Silverbush
title	A systematic approach to orient the human protein–protein interaction network
title_short	A systematic approach to orient the human protein–protein interaction network
title_full	A systematic approach to orient the human protein–protein interaction network
title_fullStr	A systematic approach to orient the human protein–protein interaction network
title_full_unstemmed	A systematic approach to orient the human protein–protein interaction network
title_sort	systematic approach to orient the human protein–protein interaction network
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3e25d3924d584a10ba7554732fedb711
work_keys_str_mv	AT danasilverbush asystematicapproachtoorientthehumanproteinproteininteractionnetwork AT rodedsharan asystematicapproachtoorientthehumanproteinproteininteractionnetwork AT danasilverbush systematicapproachtoorientthehumanproteinproteininteractionnetwork AT rodedsharan systematicapproachtoorientthehumanproteinproteininteractionnetwork
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A systematic approach to orient the human protein–protein interaction network

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