Sensory cortex underpinnings of traumatic brain injury deficits.

Traumatic brain injury (TBI) can result in persistent sensorimotor and cognitive deficits including long-term altered sensory processing. The few animal models of sensory cortical processing effects of TBI have been limited to examination of effects immediately after TBI and only in some layers of c...

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Autores principales:	Dasuni S Alwis, Edwin B Yan, Maria-Cristina Morganti-Kossmann, Ramesh Rajan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3e27099b81e04718aa743c85df83dfb0
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spelling	oai:doaj.org-article:3e27099b81e04718aa743c85df83dfb02021-11-18T08:03:57ZSensory cortex underpinnings of traumatic brain injury deficits.1932-620310.1371/journal.pone.0052169https://doaj.org/article/3e27099b81e04718aa743c85df83dfb02012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23284921/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Traumatic brain injury (TBI) can result in persistent sensorimotor and cognitive deficits including long-term altered sensory processing. The few animal models of sensory cortical processing effects of TBI have been limited to examination of effects immediately after TBI and only in some layers of cortex. We have now used the rat whisker tactile system and the cortex processing whisker-derived input to provide a highly detailed description of TBI-induced long-term changes in neuronal responses across the entire columnar network in primary sensory cortex. Brain injury (n=19) was induced using an impact acceleration method and sham controls received surgery only (n=15). Animals were tested in a range of sensorimotor behaviour tasks prior to and up to 6 weeks post-injury when there were still significant sensorimotor behaviour deficits. At 8-10 weeks post-trauma, in terminal experiments, extracellular recordings were obtained from barrel cortex neurons in response to whisker motion, including motion that mimicked whisker motion observed in awake animals undertaking different tasks. In cortex, there were lamina-specific neuronal response alterations that appeared to reflect local circuit changes. Hyper-excitation was found only in supragranular layers involved in intra-areal processing and long-range integration, and only for stimulation with complex, naturalistic whisker motion patterns and not for stimulation with simple trapezoidal whisker motion. Thus TBI induces long-term directional changes in integrative sensory cortical layers that depend on the complexity of the incoming sensory information. The nature of these changes allow predictions as to what types of sensory processes may be affected in TBI and contribute to post-trauma sensorimotor deficits.Dasuni S AlwisEdwin B YanMaria-Cristina Morganti-KossmannRamesh RajanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52169 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dasuni S Alwis Edwin B Yan Maria-Cristina Morganti-Kossmann Ramesh Rajan Sensory cortex underpinnings of traumatic brain injury deficits.
description	Traumatic brain injury (TBI) can result in persistent sensorimotor and cognitive deficits including long-term altered sensory processing. The few animal models of sensory cortical processing effects of TBI have been limited to examination of effects immediately after TBI and only in some layers of cortex. We have now used the rat whisker tactile system and the cortex processing whisker-derived input to provide a highly detailed description of TBI-induced long-term changes in neuronal responses across the entire columnar network in primary sensory cortex. Brain injury (n=19) was induced using an impact acceleration method and sham controls received surgery only (n=15). Animals were tested in a range of sensorimotor behaviour tasks prior to and up to 6 weeks post-injury when there were still significant sensorimotor behaviour deficits. At 8-10 weeks post-trauma, in terminal experiments, extracellular recordings were obtained from barrel cortex neurons in response to whisker motion, including motion that mimicked whisker motion observed in awake animals undertaking different tasks. In cortex, there were lamina-specific neuronal response alterations that appeared to reflect local circuit changes. Hyper-excitation was found only in supragranular layers involved in intra-areal processing and long-range integration, and only for stimulation with complex, naturalistic whisker motion patterns and not for stimulation with simple trapezoidal whisker motion. Thus TBI induces long-term directional changes in integrative sensory cortical layers that depend on the complexity of the incoming sensory information. The nature of these changes allow predictions as to what types of sensory processes may be affected in TBI and contribute to post-trauma sensorimotor deficits.
format	article
author	Dasuni S Alwis Edwin B Yan Maria-Cristina Morganti-Kossmann Ramesh Rajan
author_facet	Dasuni S Alwis Edwin B Yan Maria-Cristina Morganti-Kossmann Ramesh Rajan
author_sort	Dasuni S Alwis
title	Sensory cortex underpinnings of traumatic brain injury deficits.
title_short	Sensory cortex underpinnings of traumatic brain injury deficits.
title_full	Sensory cortex underpinnings of traumatic brain injury deficits.
title_fullStr	Sensory cortex underpinnings of traumatic brain injury deficits.
title_full_unstemmed	Sensory cortex underpinnings of traumatic brain injury deficits.
title_sort	sensory cortex underpinnings of traumatic brain injury deficits.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/3e27099b81e04718aa743c85df83dfb0
work_keys_str_mv	AT dasunisalwis sensorycortexunderpinningsoftraumaticbraininjurydeficits AT edwinbyan sensorycortexunderpinningsoftraumaticbraininjurydeficits AT mariacristinamorgantikossmann sensorycortexunderpinningsoftraumaticbraininjurydeficits AT rameshrajan sensorycortexunderpinningsoftraumaticbraininjurydeficits
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Sensory cortex underpinnings of traumatic brain injury deficits.

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