Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis

Abstract Vascular mechanisms are increasingly recognized in the pathophysiology of Alzheimer’s disease (AD), but less is known about the occurrence of stroke in AD patients. We aimed to quantify the risk of stroke in patients with AD and compare the incidence rates (IR) of stroke in individuals with...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	João Pinho, Miguel Quintas-Neves, Imis Dogan, Kathrin Reetz, Arno Reich, Ana Sofia Costa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3e32665d579e461bab0742c2d2913739
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3e32665d579e461bab0742c2d2913739
record_format	dspace
spelling	oai:doaj.org-article:3e32665d579e461bab0742c2d29137392021-12-02T16:28:06ZIncident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis10.1038/s41598-021-95821-x2045-2322https://doaj.org/article/3e32665d579e461bab0742c2d29137392021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95821-xhttps://doaj.org/toc/2045-2322Abstract Vascular mechanisms are increasingly recognized in the pathophysiology of Alzheimer’s disease (AD), but less is known about the occurrence of stroke in AD patients. We aimed to quantify the risk of stroke in patients with AD and compare the incidence rates (IR) of stroke in individuals without AD. Systematic search of Embase and MEDLINE between 1970 and 2020. Inclusion criteria: reports with ≥ 50 patients with non-familial AD, which reported the occurrence of stroke (all types) and/or ischemic stroke and/or intracerebral hemorrhage (ICH) during follow-up. Meta-analyses of pooled data using random-effects model were performed. IR were calculated for each study. Incidence rate ratios (IRR) were calculated for studies presenting a control-group without AD. Among 5109 retrieved studies, 29 (0.6%) fulfilled the inclusion criteria, reporting a total of 61,824 AD patients. In AD patients the IR were 15.4/1000 person-years for stroke (all types), 13.0/1000 person-years for ischemic stroke and 3.4/1000 person-years for ICH. When compared to controls without AD, incidence rate for ICH in AD patients was significantly higher (IRR = 1.67, 95%CI 1.43–1.96), but similar for ischemic stroke. Incident stroke is not a rare event in AD population. AD is associated with an increased risk of intracerebral hemorrhage which warrants further clarification.João PinhoMiguel Quintas-NevesImis DoganKathrin ReetzArno ReichAna Sofia CostaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q João Pinho Miguel Quintas-Neves Imis Dogan Kathrin Reetz Arno Reich Ana Sofia Costa Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis
description	Abstract Vascular mechanisms are increasingly recognized in the pathophysiology of Alzheimer’s disease (AD), but less is known about the occurrence of stroke in AD patients. We aimed to quantify the risk of stroke in patients with AD and compare the incidence rates (IR) of stroke in individuals without AD. Systematic search of Embase and MEDLINE between 1970 and 2020. Inclusion criteria: reports with ≥ 50 patients with non-familial AD, which reported the occurrence of stroke (all types) and/or ischemic stroke and/or intracerebral hemorrhage (ICH) during follow-up. Meta-analyses of pooled data using random-effects model were performed. IR were calculated for each study. Incidence rate ratios (IRR) were calculated for studies presenting a control-group without AD. Among 5109 retrieved studies, 29 (0.6%) fulfilled the inclusion criteria, reporting a total of 61,824 AD patients. In AD patients the IR were 15.4/1000 person-years for stroke (all types), 13.0/1000 person-years for ischemic stroke and 3.4/1000 person-years for ICH. When compared to controls without AD, incidence rate for ICH in AD patients was significantly higher (IRR = 1.67, 95%CI 1.43–1.96), but similar for ischemic stroke. Incident stroke is not a rare event in AD population. AD is associated with an increased risk of intracerebral hemorrhage which warrants further clarification.
format	article
author	João Pinho Miguel Quintas-Neves Imis Dogan Kathrin Reetz Arno Reich Ana Sofia Costa
author_facet	João Pinho Miguel Quintas-Neves Imis Dogan Kathrin Reetz Arno Reich Ana Sofia Costa
author_sort	João Pinho
title	Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis
title_short	Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis
title_full	Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis
title_fullStr	Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis
title_full_unstemmed	Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis
title_sort	incident stroke in patients with alzheimer’s disease: systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3e32665d579e461bab0742c2d2913739
work_keys_str_mv	AT joaopinho incidentstrokeinpatientswithalzheimersdiseasesystematicreviewandmetaanalysis AT miguelquintasneves incidentstrokeinpatientswithalzheimersdiseasesystematicreviewandmetaanalysis AT imisdogan incidentstrokeinpatientswithalzheimersdiseasesystematicreviewandmetaanalysis AT kathrinreetz incidentstrokeinpatientswithalzheimersdiseasesystematicreviewandmetaanalysis AT arnoreich incidentstrokeinpatientswithalzheimersdiseasesystematicreviewandmetaanalysis AT anasofiacosta incidentstrokeinpatientswithalzheimersdiseasesystematicreviewandmetaanalysis
_version_	1718383924353171456

Incident stroke in patients with Alzheimer’s disease: systematic review and meta-analysis

Ejemplares similares