High-fat diet disturbs lipid raft/TGF-β signaling-mediated maintenance of hematopoietic stem cells in mouse bone marrow

High fat diets (HFD) are thought to perturb murine hematopoiesis as a result of obesity. Here the authors find that short-term HFD reduces hematopoietic stem cells (HSC), disrupts lipid rafts and TGF-β1 signalling. Injecting HFD-fed mice with recombinant TGF-β1 can rescue HSC loss.

Guardado en:

Detalles Bibliográficos
Autores principales:	François Hermetet, Anne Buffière, Aziza Aznague, Jean-Paul Pais de Barros, Jean-Noël Bastie, Laurent Delva, Ronan Quéré
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e421fb436c9409f853e3bfaa2e091f0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3e421fb436c9409f853e3bfaa2e091f0
record_format	dspace
spelling	oai:doaj.org-article:3e421fb436c9409f853e3bfaa2e091f02021-12-02T15:35:58ZHigh-fat diet disturbs lipid raft/TGF-β signaling-mediated maintenance of hematopoietic stem cells in mouse bone marrow10.1038/s41467-018-08228-02041-1723https://doaj.org/article/3e421fb436c9409f853e3bfaa2e091f02019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08228-0https://doaj.org/toc/2041-1723High fat diets (HFD) are thought to perturb murine hematopoiesis as a result of obesity. Here the authors find that short-term HFD reduces hematopoietic stem cells (HSC), disrupts lipid rafts and TGF-β1 signalling. Injecting HFD-fed mice with recombinant TGF-β1 can rescue HSC loss.François HermetetAnne BuffièreAziza AznagueJean-Paul Pais de BarrosJean-Noël BastieLaurent DelvaRonan QuéréNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q François Hermetet Anne Buffière Aziza Aznague Jean-Paul Pais de Barros Jean-Noël Bastie Laurent Delva Ronan Quéré High-fat diet disturbs lipid raft/TGF-β signaling-mediated maintenance of hematopoietic stem cells in mouse bone marrow
description	High fat diets (HFD) are thought to perturb murine hematopoiesis as a result of obesity. Here the authors find that short-term HFD reduces hematopoietic stem cells (HSC), disrupts lipid rafts and TGF-β1 signalling. Injecting HFD-fed mice with recombinant TGF-β1 can rescue HSC loss.
format	article
author	François Hermetet Anne Buffière Aziza Aznague Jean-Paul Pais de Barros Jean-Noël Bastie Laurent Delva Ronan Quéré
author_facet	François Hermetet Anne Buffière Aziza Aznague Jean-Paul Pais de Barros Jean-Noël Bastie Laurent Delva Ronan Quéré
author_sort	François Hermetet
title	High-fat diet disturbs lipid raft/TGF-β signaling-mediated maintenance of hematopoietic stem cells in mouse bone marrow
title_short	High-fat diet disturbs lipid raft/TGF-β signaling-mediated maintenance of hematopoietic stem cells in mouse bone marrow
title_full	High-fat diet disturbs lipid raft/TGF-β signaling-mediated maintenance of hematopoietic stem cells in mouse bone marrow
title_fullStr	High-fat diet disturbs lipid raft/TGF-β signaling-mediated maintenance of hematopoietic stem cells in mouse bone marrow
title_full_unstemmed	High-fat diet disturbs lipid raft/TGF-β signaling-mediated maintenance of hematopoietic stem cells in mouse bone marrow
title_sort	high-fat diet disturbs lipid raft/tgf-β signaling-mediated maintenance of hematopoietic stem cells in mouse bone marrow
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3e421fb436c9409f853e3bfaa2e091f0
work_keys_str_mv	AT francoishermetet highfatdietdisturbslipidrafttgfbsignalingmediatedmaintenanceofhematopoieticstemcellsinmousebonemarrow AT annebuffiere highfatdietdisturbslipidrafttgfbsignalingmediatedmaintenanceofhematopoieticstemcellsinmousebonemarrow AT azizaaznague highfatdietdisturbslipidrafttgfbsignalingmediatedmaintenanceofhematopoieticstemcellsinmousebonemarrow AT jeanpaulpaisdebarros highfatdietdisturbslipidrafttgfbsignalingmediatedmaintenanceofhematopoieticstemcellsinmousebonemarrow AT jeannoelbastie highfatdietdisturbslipidrafttgfbsignalingmediatedmaintenanceofhematopoieticstemcellsinmousebonemarrow AT laurentdelva highfatdietdisturbslipidrafttgfbsignalingmediatedmaintenanceofhematopoieticstemcellsinmousebonemarrow AT ronanquere highfatdietdisturbslipidrafttgfbsignalingmediatedmaintenanceofhematopoieticstemcellsinmousebonemarrow
_version_	1718386405846024192

High-fat diet disturbs lipid raft/TGF-β signaling-mediated maintenance of hematopoietic stem cells in mouse bone marrow

Ejemplares similares