The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers
Cay Anderson-Hanley,1 Jessica Stark,1 Kathryn M Wall,1 Marisa VanBrakle,1 Makenzie Michel,1 Molly Maloney,1 Nicole Barcelos,1 Kristina Striegnitz,2 Brian D Cohen,3 Arthur F Kramer4 1Healthy Aging & Neuropsychology Lab, Department of Psychology & Neuroscience Program, Union College,...
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Dove Medical Press
2018
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oai:doaj.org-article:3e49d02c80f34587b3b9f15bf85c75d22021-12-02T04:50:36ZThe interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers1178-1998https://doaj.org/article/3e49d02c80f34587b3b9f15bf85c75d22018-09-01T00:00:00Zhttps://www.dovepress.com/the-interactive-physical-and-cognitive-exercise-system-ipacestrade-eff-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Cay Anderson-Hanley,1 Jessica Stark,1 Kathryn M Wall,1 Marisa VanBrakle,1 Makenzie Michel,1 Molly Maloney,1 Nicole Barcelos,1 Kristina Striegnitz,2 Brian D Cohen,3 Arthur F Kramer4 1Healthy Aging & Neuropsychology Lab, Department of Psychology & Neuroscience Program, Union College, Schenectady, NY, USA; 2Computer Science Department & Neuroscience Program, Union College, Schenectady, NY, USA; 3Biology Department, Union College, Schenectady, NY, USA; 4Center for Cognitive & Brain Health, Department of Psychology, Northeastern University, Boston, MA, USA Background: Alzheimer’s and related dementias are on the rise, and older adults and their families are seeking accessible and effective ways to stave off or ameliorate mild cognitive impairment (MCI).Aim: This pilot clinical trial (ClinicalTrials.gov Identifier: 03069391) examined neuropsychological and neurobiological outcomes of interactive physical and mental exercise.Participants and methods: Older adults (MCI and caregivers) were enrolled in a 3-month, in-home trial of a portable neuro-exergame (the interactive Physical and Cognitive Exercise System [iPACES™]), in which they pedaled and steered along a virtual bike path to complete a list of errands (Memory Lane™). Neuropsychological function and salivary biomarkers were measured at pre-, mid-, and posttrial. Ten older adults complied with the recommended use of iPACES (complete dose; ≥2×/wk, 67% of the 15 who also had pre- and postevaluation data). Statistical analyses compared change over time and also change among those with a complete dose vs inadequate dose. Correlations between change in neuropsychological and biomarker measures were also examined.Results: Executive function and verbal memory increased after 3 months (p = 0.01; no significant change was found with an inadequate dose). Change in salivary biomarkers was moderately associated with increasing cognition (cortisol, r = 0.68; IGF-1, r = 0.37).Conclusion: Further research is needed, but these pilot data provide preliminary indications to suggest neuro-exergaming can impact cognitive function, perhaps via neurobiological mechanisms, and as such may provide an effective and practical way to promote healthy aging. Keywords: aging, cognition, MCI, exergame, executive function, neurogame, neuro-exergameAnderson-Hanley CStark JWall KMVanBrakle MMichel MMaloney MBarcelos NStriegnitz KCohen BDKramer AFDove Medical PressarticleagingexercisecognitionMCIexergameexecutive functionGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 1565-1577 (2018) |
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aging exercise cognition MCI exergame executive function Geriatrics RC952-954.6 |
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aging exercise cognition MCI exergame executive function Geriatrics RC952-954.6 Anderson-Hanley C Stark J Wall KM VanBrakle M Michel M Maloney M Barcelos N Striegnitz K Cohen BD Kramer AF The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers |
| description |
Cay Anderson-Hanley,1 Jessica Stark,1 Kathryn M Wall,1 Marisa VanBrakle,1 Makenzie Michel,1 Molly Maloney,1 Nicole Barcelos,1 Kristina Striegnitz,2 Brian D Cohen,3 Arthur F Kramer4 1Healthy Aging & Neuropsychology Lab, Department of Psychology & Neuroscience Program, Union College, Schenectady, NY, USA; 2Computer Science Department & Neuroscience Program, Union College, Schenectady, NY, USA; 3Biology Department, Union College, Schenectady, NY, USA; 4Center for Cognitive & Brain Health, Department of Psychology, Northeastern University, Boston, MA, USA Background: Alzheimer’s and related dementias are on the rise, and older adults and their families are seeking accessible and effective ways to stave off or ameliorate mild cognitive impairment (MCI).Aim: This pilot clinical trial (ClinicalTrials.gov Identifier: 03069391) examined neuropsychological and neurobiological outcomes of interactive physical and mental exercise.Participants and methods: Older adults (MCI and caregivers) were enrolled in a 3-month, in-home trial of a portable neuro-exergame (the interactive Physical and Cognitive Exercise System [iPACES™]), in which they pedaled and steered along a virtual bike path to complete a list of errands (Memory Lane™). Neuropsychological function and salivary biomarkers were measured at pre-, mid-, and posttrial. Ten older adults complied with the recommended use of iPACES (complete dose; ≥2×/wk, 67% of the 15 who also had pre- and postevaluation data). Statistical analyses compared change over time and also change among those with a complete dose vs inadequate dose. Correlations between change in neuropsychological and biomarker measures were also examined.Results: Executive function and verbal memory increased after 3 months (p = 0.01; no significant change was found with an inadequate dose). Change in salivary biomarkers was moderately associated with increasing cognition (cortisol, r = 0.68; IGF-1, r = 0.37).Conclusion: Further research is needed, but these pilot data provide preliminary indications to suggest neuro-exergaming can impact cognitive function, perhaps via neurobiological mechanisms, and as such may provide an effective and practical way to promote healthy aging. Keywords: aging, cognition, MCI, exergame, executive function, neurogame, neuro-exergame |
| format |
article |
| author |
Anderson-Hanley C Stark J Wall KM VanBrakle M Michel M Maloney M Barcelos N Striegnitz K Cohen BD Kramer AF |
| author_facet |
Anderson-Hanley C Stark J Wall KM VanBrakle M Michel M Maloney M Barcelos N Striegnitz K Cohen BD Kramer AF |
| author_sort |
Anderson-Hanley C |
| title |
The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers |
| title_short |
The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers |
| title_full |
The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers |
| title_fullStr |
The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers |
| title_full_unstemmed |
The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers |
| title_sort |
interactive physical and cognitive exercise system (ipaces™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers |
| publisher |
Dove Medical Press |
| publishDate |
2018 |
| url |
https://doaj.org/article/3e49d02c80f34587b3b9f15bf85c75d2 |
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