Multifaceted prospects of nanocomposites for cardiovascular grafts and stents

Muthu Vignesh Vellayappan,1 Arunpandian Balaji,1 Aruna Priyadarshini Subramanian,1 Agnes Aruna John,1 Saravana Kumar Jaganathan,1 Selvakumar Murugesan,2 Eko Supriyanto,1 Mustafa Yusof1 1IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi...

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Autores principales:	Vellayappan MV, Balaji A, Subramanian AP, John AA, Jaganathan SK, Murugesan S, Supriyanto E, Yusof M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3e4bce3b6e0446dea57c29aedd42667e
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spelling	oai:doaj.org-article:3e4bce3b6e0446dea57c29aedd42667e2021-12-02T05:04:23ZMultifaceted prospects of nanocomposites for cardiovascular grafts and stents1178-2013https://doaj.org/article/3e4bce3b6e0446dea57c29aedd42667e2015-04-01T00:00:00Zhttp://www.dovepress.com/multifaceted-prospects-of-nanocomposites-for-cardiovascular-grafts-and-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Muthu Vignesh Vellayappan,1 Arunpandian Balaji,1 Aruna Priyadarshini Subramanian,1 Agnes Aruna John,1 Saravana Kumar Jaganathan,1 Selvakumar Murugesan,2 Eko Supriyanto,1 Mustafa Yusof1 1IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia; 2Rubber Technology Center, Indian Institute of Technology, Kharagpur, India Abstract: Cardiovascular disease is the leading cause of death across the globe. The use of synthetic materials is indispensable in the treatment of cardiovascular disease. Major drawbacks related to the use of biomaterials are their mechanical properties and biocompatibility, and these have to be circumvented before promoting the material to the market or clinical setting. Revolutionary advancements in nanotechnology have introduced a novel class of materials called nanocomposites which have superior properties for biomedical applications. Recently, there has been a widespread recognition of the nanocomposites utilizing polyhedral oligomeric silsesquioxane, bacterial cellulose, silk fibroin, iron oxide magnetic nanoparticles, and carbon nanotubes in cardiovascular grafts and stents. The unique characteristics of these nanocomposites have led to the development of a wide range of nanostructured copolymers with appreciably enhanced properties, such as improved mechanical, chemical, and physical characteristics suitable for cardiovascular implants. The incorporation of advanced nanocomposite materials in cardiovascular grafts and stents improves hemocompatibility, enhances antithrombogenicity, improves mechanical and surface properties, and decreases the microbial response to the cardiovascular implants. A thorough attempt is made to summarize the various applications of nanocomposites for cardiovascular graft and stent applications. This review will highlight the recent advances in nanocomposites and also address the need of future research in promoting nanocomposites as plausible candidates in a campaign against cardiovascular disease. Keywords: nanocomposites, vascular grafts, stents, hemocompatibility, nanoparticles, cardiovascular biomaterialsVellayappan MVBalaji ASubramanian APJohn AAJaganathan SKMurugesan SSupriyanto EYusof MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 2785-2803 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Vellayappan MV Balaji A Subramanian AP John AA Jaganathan SK Murugesan S Supriyanto E Yusof M Multifaceted prospects of nanocomposites for cardiovascular grafts and stents
description	Muthu Vignesh Vellayappan,1 Arunpandian Balaji,1 Aruna Priyadarshini Subramanian,1 Agnes Aruna John,1 Saravana Kumar Jaganathan,1 Selvakumar Murugesan,2 Eko Supriyanto,1 Mustafa Yusof1 1IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia; 2Rubber Technology Center, Indian Institute of Technology, Kharagpur, India Abstract: Cardiovascular disease is the leading cause of death across the globe. The use of synthetic materials is indispensable in the treatment of cardiovascular disease. Major drawbacks related to the use of biomaterials are their mechanical properties and biocompatibility, and these have to be circumvented before promoting the material to the market or clinical setting. Revolutionary advancements in nanotechnology have introduced a novel class of materials called nanocomposites which have superior properties for biomedical applications. Recently, there has been a widespread recognition of the nanocomposites utilizing polyhedral oligomeric silsesquioxane, bacterial cellulose, silk fibroin, iron oxide magnetic nanoparticles, and carbon nanotubes in cardiovascular grafts and stents. The unique characteristics of these nanocomposites have led to the development of a wide range of nanostructured copolymers with appreciably enhanced properties, such as improved mechanical, chemical, and physical characteristics suitable for cardiovascular implants. The incorporation of advanced nanocomposite materials in cardiovascular grafts and stents improves hemocompatibility, enhances antithrombogenicity, improves mechanical and surface properties, and decreases the microbial response to the cardiovascular implants. A thorough attempt is made to summarize the various applications of nanocomposites for cardiovascular graft and stent applications. This review will highlight the recent advances in nanocomposites and also address the need of future research in promoting nanocomposites as plausible candidates in a campaign against cardiovascular disease. Keywords: nanocomposites, vascular grafts, stents, hemocompatibility, nanoparticles, cardiovascular biomaterials
format	article
author	Vellayappan MV Balaji A Subramanian AP John AA Jaganathan SK Murugesan S Supriyanto E Yusof M
author_facet	Vellayappan MV Balaji A Subramanian AP John AA Jaganathan SK Murugesan S Supriyanto E Yusof M
author_sort	Vellayappan MV
title	Multifaceted prospects of nanocomposites for cardiovascular grafts and stents
title_short	Multifaceted prospects of nanocomposites for cardiovascular grafts and stents
title_full	Multifaceted prospects of nanocomposites for cardiovascular grafts and stents
title_fullStr	Multifaceted prospects of nanocomposites for cardiovascular grafts and stents
title_full_unstemmed	Multifaceted prospects of nanocomposites for cardiovascular grafts and stents
title_sort	multifaceted prospects of nanocomposites for cardiovascular grafts and stents
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/3e4bce3b6e0446dea57c29aedd42667e
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Multifaceted prospects of nanocomposites for cardiovascular grafts and stents

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