The multiple mechanisms of MCL1 in the regulation of cell fate

In this review Widden and Placzek synthesize studies characterizing the influence that myeloid cell leukemia-1 (MCL1) has on cell proliferation, DNA damage response, autophagy, calcium handling, and mitochondrial quality control to highlight the broader scope that it plays in cellular homeostasis re...

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Autores principales:	Hayley Widden, William J. Placzek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3e4c89c0ce7e405aa2ea6b1f132107cc
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spelling	oai:doaj.org-article:3e4c89c0ce7e405aa2ea6b1f132107cc2021-12-02T15:28:56ZThe multiple mechanisms of MCL1 in the regulation of cell fate10.1038/s42003-021-02564-62399-3642https://doaj.org/article/3e4c89c0ce7e405aa2ea6b1f132107cc2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02564-6https://doaj.org/toc/2399-3642In this review Widden and Placzek synthesize studies characterizing the influence that myeloid cell leukemia-1 (MCL1) has on cell proliferation, DNA damage response, autophagy, calcium handling, and mitochondrial quality control to highlight the broader scope that it plays in cellular homeostasis regulation. They discuss which pathways are likely to be impacted by emerging MCL1 inhibitors, as well as highlight non-cancerous disease states that could deploy BH3-mimetics in the future.Hayley WiddenWilliam J. PlaczekNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Hayley Widden William J. Placzek The multiple mechanisms of MCL1 in the regulation of cell fate
description	In this review Widden and Placzek synthesize studies characterizing the influence that myeloid cell leukemia-1 (MCL1) has on cell proliferation, DNA damage response, autophagy, calcium handling, and mitochondrial quality control to highlight the broader scope that it plays in cellular homeostasis regulation. They discuss which pathways are likely to be impacted by emerging MCL1 inhibitors, as well as highlight non-cancerous disease states that could deploy BH3-mimetics in the future.
format	article
author	Hayley Widden William J. Placzek
author_facet	Hayley Widden William J. Placzek
author_sort	Hayley Widden
title	The multiple mechanisms of MCL1 in the regulation of cell fate
title_short	The multiple mechanisms of MCL1 in the regulation of cell fate
title_full	The multiple mechanisms of MCL1 in the regulation of cell fate
title_fullStr	The multiple mechanisms of MCL1 in the regulation of cell fate
title_full_unstemmed	The multiple mechanisms of MCL1 in the regulation of cell fate
title_sort	multiple mechanisms of mcl1 in the regulation of cell fate
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3e4c89c0ce7e405aa2ea6b1f132107cc
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The multiple mechanisms of MCL1 in the regulation of cell fate

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