Distribution and diversity of enzymes for polysaccharide degradation in fungi

Abstract Fungi are important polysaccharide degraders in the environment and for biotechnology. Here, the increasing number of sequenced fungal genomes allowed for systematic identification of genes and proteins involved in polysaccharide degradation in 218 fungi. Globally, 9,003 sequences for glyco...

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Autor principal:	Renaud Berlemont
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3e4da5a8138f487ea5fdcfd91aed3249
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spelling	oai:doaj.org-article:3e4da5a8138f487ea5fdcfd91aed32492021-12-02T16:06:37ZDistribution and diversity of enzymes for polysaccharide degradation in fungi10.1038/s41598-017-00258-w2045-2322https://doaj.org/article/3e4da5a8138f487ea5fdcfd91aed32492017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00258-whttps://doaj.org/toc/2045-2322Abstract Fungi are important polysaccharide degraders in the environment and for biotechnology. Here, the increasing number of sequenced fungal genomes allowed for systematic identification of genes and proteins involved in polysaccharide degradation in 218 fungi. Globally, 9,003 sequences for glycoside hydrolases and lytic polysaccharide mono-oxygenases targeting cellulose, xylan, and chitin, were identified. Although abundant in most lineages, the distribution of these enzymes is variable even between organisms from the same genus. However, most fungi are generalists possessing several enzymes for polysaccharide deconstruction. Most identified enzymes were small proteins with simple domain organization or eventually consisted of one catalytic domain associated with a non-catalytic accessory domain. Thus unlike bacteria, fungi's ability to degrade polysaccharides relies on apparent redundancy in functional traits and the high frequency of lytic polysaccharide mono-oxygenases, as well as other physiological adaptation such as hyphal growth. Globally, this study provides a comprehensive framework to further identify enzymes for polysaccharide deconstruction in fungal genomes and will help identify new strains and enzymes with potential for biotechnological application.Renaud BerlemontNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Renaud Berlemont Distribution and diversity of enzymes for polysaccharide degradation in fungi
description	Abstract Fungi are important polysaccharide degraders in the environment and for biotechnology. Here, the increasing number of sequenced fungal genomes allowed for systematic identification of genes and proteins involved in polysaccharide degradation in 218 fungi. Globally, 9,003 sequences for glycoside hydrolases and lytic polysaccharide mono-oxygenases targeting cellulose, xylan, and chitin, were identified. Although abundant in most lineages, the distribution of these enzymes is variable even between organisms from the same genus. However, most fungi are generalists possessing several enzymes for polysaccharide deconstruction. Most identified enzymes were small proteins with simple domain organization or eventually consisted of one catalytic domain associated with a non-catalytic accessory domain. Thus unlike bacteria, fungi's ability to degrade polysaccharides relies on apparent redundancy in functional traits and the high frequency of lytic polysaccharide mono-oxygenases, as well as other physiological adaptation such as hyphal growth. Globally, this study provides a comprehensive framework to further identify enzymes for polysaccharide deconstruction in fungal genomes and will help identify new strains and enzymes with potential for biotechnological application.
format	article
author	Renaud Berlemont
author_facet	Renaud Berlemont
author_sort	Renaud Berlemont
title	Distribution and diversity of enzymes for polysaccharide degradation in fungi
title_short	Distribution and diversity of enzymes for polysaccharide degradation in fungi
title_full	Distribution and diversity of enzymes for polysaccharide degradation in fungi
title_fullStr	Distribution and diversity of enzymes for polysaccharide degradation in fungi
title_full_unstemmed	Distribution and diversity of enzymes for polysaccharide degradation in fungi
title_sort	distribution and diversity of enzymes for polysaccharide degradation in fungi
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3e4da5a8138f487ea5fdcfd91aed3249
work_keys_str_mv	AT renaudberlemont distributionanddiversityofenzymesforpolysaccharidedegradationinfungi
_version_	1718384956188655616

Distribution and diversity of enzymes for polysaccharide degradation in fungi

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